Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5hprovided by MGI
Official Full Name: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit Dprovided by MGI
Primary source: MGI:MGI:1918929
See related: Ensembl:ENSMUSG00000034566 AllianceGenome:MGI:1918929
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atp5pd; 0610009D10Rik
Summary: Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ATP5PD (ATP synthase peripheral stalk subunit d). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 94.5), CNS E11.5 (RPKM 81.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 E2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115306517..115310745, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115415691..115419919, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

multimodality resistance arises through a core metabolic reprogramming pathway instigated by epigenetic loss of the ATP synthase subunit ATP5H, which leads to ROS accumulation and HIF-1alpha stabilization under normoxia
Title: Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Atp5h (e-PCR), detects polymorphism
- UniSTS:546673

Homology

Homologs of the Atp5h gene: The Atp5h gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 489 organisms have orthologs with human gene Atp5h
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in proton motive force-driven mitochondrial ATP synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase, stator stalk	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit d, mitochondrial

Names: ATP synthase peripheral stalk subunit d; ATPase subunit d

NP_082138.1

EC 3.6.1.14

XP_006534317.1

EC 3.6.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417932.1 → NP_001404861.1 ATP synthase subunit d, mitochondrial

Status: VALIDATED

Source sequence(s)

AL627096
NM_001417933.1 → NP_001404862.1 ATP synthase subunit d, mitochondrial

Status: VALIDATED

Source sequence(s)

AL627096
NM_001417934.1 → NP_001404863.1 ATP synthase subunit d, mitochondrial

Status: VALIDATED

Source sequence(s)

AL627096
NM_027862.2 → NP_082138.1 ATP synthase subunit d, mitochondrial

See identical proteins and their annotated locations for NP_082138.1

Status: VALIDATED

Source sequence(s)

AL627096

Consensus CDS

CCDS25633.1

UniProtKB/Swiss-Prot

Q91YK9, Q9DCX2

UniProtKB/TrEMBL

A0A8C6IAW4

Related

ENSMUSP00000046256.3, ENSMUST00000043931.9

Conserved Domains (1) summary

pfam05873
Location:3 → 155

Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)

RNA

NR_184656.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627096

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115306517..115310745 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534254.3 → XP_006534317.1 ATP synthase subunit d, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q91YK9, Q9DCX2

UniProtKB/TrEMBL

A0A8C6IAW4

Related

ENSMUSP00000102147.2, ENSMUST00000106537.8

Conserved Domains (1) summary

pfam05873
Location:3 → 155

Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)