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Zgrf1 zinc finger, GRF-type containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71643, updated on 8-Dec-2022

Summary

Official Symbol
Zgrf1provided by MGI
Official Full Name
zinc finger, GRF-type containing 1provided by MGI
Primary source
MGI:MGI:1918893
See related
Ensembl:ENSMUSG00000051278 AllianceGenome:MGI:1918893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930422G04Rik
Summary
Predicted to enable 5'-flap endonuclease activity and RNA binding activity. Predicted to be involved in replication fork reversal. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Is expressed in brain ventricular layer and nose. Orthologous to human ZGRF1 (zinc finger GRF-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 4.0), limb E14.5 (RPKM 2.2) and 14 other tissues See more
Orthologs
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Genomic context

See Zgrf1 in Genome Data Viewer
Location:
3; 3 G2
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127347080..127411672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127553396..127618023)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 7, transcriptional regulator Neighboring gene predicted gene, 51018 Neighboring gene microRNA 302d Neighboring gene microRNA 367 Neighboring gene predicted gene, 40147 Neighboring gene neurogenin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein ZGRF1
Names
GRF-type zinc finger domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197997.2NP_932114.2  protein ZGRF1

    See identical proteins and their annotated locations for NP_932114.2

    Status: VALIDATED

    Source sequence(s)
    AK046429, BC079891, CO044435
    Consensus CDS
    CCDS51066.1
    UniProtKB/Swiss-Prot
    E9Q2K6, Q0VGT4
    UniProtKB/TrEMBL
    Q8BQU5
    Related
    ENSMUSP00000044432.5, ENSMUST00000043108.9
    Conserved Domains (5) summary
    COG1112
    Location:14871837
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:11091153
    zf-GRF; GRF zinc finger
    pfam10382
    Location:372
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:13761605
    AAA_11; AAA domain
    pfam13087
    Location:16161800
    AAA_12; AAA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    127347080..127411672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319725.3XP_017175214.1  protein ZGRF1 isoform X1

    Conserved Domains (4) summary
    TIGR00376
    Location:15682003
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:12671311
    zf-GRF; GRF zinc finger
    pfam10382
    Location:375
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:17741981
    AAA_12; AAA domain
  2. XM_017319726.3XP_017175215.1  protein ZGRF1 isoform X3

    Conserved Domains (4) summary
    TIGR00376
    Location:14101845
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:11091153
    zf-GRF; GRF zinc finger
    pfam10382
    Location:375
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:16161823
    AAA_12; AAA domain
  3. XM_030252824.2XP_030108684.1  protein ZGRF1 isoform X6

    Conserved Domains (3) summary
    TIGR00376
    Location:542977
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:241285
    zf-GRF; GRF zinc finger
    pfam13087
    Location:748955
    AAA_12; AAA domain
  4. XM_006502109.5XP_006502172.1  protein ZGRF1 isoform X2

    Conserved Domains (4) summary
    TIGR00376
    Location:15681980
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:12671311
    zf-GRF; GRF zinc finger
    pfam10382
    Location:375
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:17741958
    AAA_12; AAA domain
  5. XM_011240233.4XP_011238535.1  protein ZGRF1 isoform X4

    Conserved Domains (1) summary
    pfam10382
    Location:375
    DUF2439; Protein of unknown function (DUF2439)
  6. XM_030252825.2XP_030108685.1  protein ZGRF1 isoform X6

    Conserved Domains (3) summary
    TIGR00376
    Location:542977
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:241285
    zf-GRF; GRF zinc finger
    pfam13087
    Location:748955
    AAA_12; AAA domain
  7. XM_017319727.3XP_017175216.1  protein ZGRF1 isoform X5

    Conserved Domains (3) summary
    TIGR00376
    Location:6941129
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:393437
    zf-GRF; GRF zinc finger
    pfam13087
    Location:9001107
    AAA_12; AAA domain
  8. XM_036163332.1XP_036019225.1  protein ZGRF1 isoform X8

    Conserved Domains (3) summary
    pfam06839
    Location:953
    zf-GRF; GRF zinc finger
    pfam13087
    Location:516700
    AAA_12; AAA domain
    cl28899
    Location:275539
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  9. XM_036163331.1XP_036019224.1  protein ZGRF1 isoform X7

    Conserved Domains (3) summary
    pfam06839
    Location:953
    zf-GRF; GRF zinc finger
    pfam13087
    Location:516723
    AAA_12; AAA domain
    cl28899
    Location:275525
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RNA

  1. XR_867232.3 RNA Sequence

    Related
    ENSMUST00000200490.5
  2. XR_004941395.1 RNA Sequence