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TPBG trophoblast glycoprotein [ Homo sapiens (human) ]

Gene ID: 7162, updated on 13-Mar-2020

Summary

Official Symbol
TPBGprovided by HGNC
Official Full Name
trophoblast glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:12004
See related
Ensembl:ENSG00000146242 MIM:190920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5T4; M6P1; 5T4AG; WAIF1
Summary
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in esophagus (RPKM 8.0), endometrium (RPKM 5.0) and 22 other tissues See more
Orthologs

Genomic context

See TPBG in Genome Data Viewer
Location:
6q14.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (82362983..82367420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83072923..83077134)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene single stranded DNA binding protein 2 pseudogene Neighboring gene uncharacterized LOC105377874 Neighboring gene uncharacterized LOC105377875 Neighboring gene uncharacterized LOC105377876 Neighboring gene uncharacterized LOC105377877

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface HDA PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
trophoblast glycoprotein
Names
5T4 oncofetal antigen
5T4 oncofetal trophoblast glycoprotein
5T4 oncotrophoblast glycoprotein
wnt-activated inhibitory factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033981.1 RefSeqGene

    Range
    5001..9212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166392.2NP_001159864.1  trophoblast glycoprotein precursor

    See identical proteins and their annotated locations for NP_001159864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL121977
    Consensus CDS
    CCDS4995.1
    UniProtKB/Swiss-Prot
    Q13641
    Related
    ENSP00000440049.1, ENST00000543496.3
    Conserved Domains (5) summary
    smart00013
    Location:6195
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:294345
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:7395
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234271
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:211270
    LRR_8; Leucine rich repeat
  2. NM_001376922.1NP_001363851.1  trophoblast glycoprotein precursor

    Status: VALIDATED

    Source sequence(s)
    AL121977
    Related
    ENSP00000358765.3, ENST00000369750.3
  3. NM_006670.5NP_006661.1  trophoblast glycoprotein precursor

    See identical proteins and their annotated locations for NP_006661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL121977
    Consensus CDS
    CCDS4995.1
    UniProtKB/Swiss-Prot
    Q13641
    Related
    ENSP00000441219.1, ENST00000535040.4
    Conserved Domains (5) summary
    smart00013
    Location:6195
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:294345
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:7395
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234271
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:211270
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    82362983..82367420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171802.1 Reference GRCh38.p13 PATCHES

    Range
    232798..237235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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