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Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 71584, updated on 20-May-2018

Summary

Official Symbol
Gdpd2provided by MGI
Official Full Name
glycerophosphodiester phosphodiesterase domain containing 2provided by MGI
Primary source
MGI:MGI:1918834
See related
Ensembl:ENSMUSG00000019359 Vega:OTTMUSG00000018299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gde3; Obdpf; 9130017L10Rik
Summary
This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in spleen adult (RPKM 33.6), duodenum adult (RPKM 20.7) and 13 other tissues See more
Orthologs

Genomic context

See Gdpd2 in Genome Data Viewer
Location:
X; X C3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (100729835..100738901)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (97925186..97934238)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4 Neighboring gene predicted gene 14902 Neighboring gene discs large MAGUK scaffold protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
glycerophosphodiester phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
glycerophosphoinositol inositolphosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin filament reorganization IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycerophosphoinositol inositolphosphodiesterase GDPD2
Names
glycerophosphodiester phosphodiesterase 3
osteoblast differentiation promoting factor
NP_001292870.1
NP_076097.1
XP_006528358.1
XP_006528360.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305941.1NP_001292870.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

    See identical proteins and their annotated locations for NP_001292870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018634, AK086508, BE948924
    Consensus CDS
    CCDS30306.1
    UniProtKB/Swiss-Prot
    Q9ESM6
    Related
    ENSMUSP00000109373.1, OTTMUSP00000020002, ENSMUST00000113744.1, OTTMUST00000044501
    Conserved Domains (1) summary
    cl14615
    Location:198500
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  2. NM_001358507.1NP_001345436.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

    Status: REVIEWED

    Source sequence(s)
    BE948924, BX005480
    Conserved Domains (1) summary
    cl14615
    Location:198500
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  3. NM_023608.4NP_076097.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

    See identical proteins and their annotated locations for NP_076097.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018634, BB844010, BE948924, BX005480
    Consensus CDS
    CCDS30306.1
    UniProtKB/Swiss-Prot
    Q9ESM6
    Related
    ENSMUSP00000019503.7, OTTMUSP00000019876, ENSMUST00000019503.13, OTTMUST00000044210
    Conserved Domains (1) summary
    cl14615
    Location:198500
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    100729835..100738901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528297.3XP_006528360.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2

    Conserved Domains (2) summary
    pfam03009
    Location:26267
    GDPD; Glycerophosphoryl diester phosphodiesterase family
    cl14615
    Location:4296
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  2. XM_006528295.1XP_006528358.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESM6
    Conserved Domains (1) summary
    cl14615
    Location:198500
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
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