TNF tumor necrosis factor [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: TNFprovided by VGNC
Official Full Name: tumor necrosis factorprovided by VGNC
Primary source: VGNC:VGNC:83501
Locus tag: EGK_14705
See related: Ensembl:ENSMMUG00000045654
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: TNLG1F; TNF-ALPHA
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	T2T-MMU8v2.0 (GCF_049350105.2)	4	NC_133409.1 (150752209..150754815, complement)
103	previous assembly	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (137934540..137937146, complement)

Chromosome 4 - NC_133409.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Title: Role of TNF in the altered interaction of dormant Mycobacterium tuberculosis with host macrophages.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Title: Enhanced innate antiviral gene expression, IFN-α, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection.
Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
Title: Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model.

Submit: New GeneRIF Correction

General gene information

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Markers

Tnf (e-PCR), detects polymorphism
- UniSTS:144649

PMC150895P1 (e-PCR)
- UniSTS:271115

PMC130126P1 (e-PCR)
- UniSTS:270612

RH17367 (e-PCR)
- UniSTS:56874

PMC108024P2 (e-PCR)
- UniSTS:270131

GDB:624603 (e-PCR)
- UniSTS:158353

GDB:624619 (e-PCR)
- UniSTS:158354

PMC165077P1 (e-PCR)
- UniSTS:271531

PMC165077P2 (e-PCR)
- UniSTS:271532

G44361 (e-PCR)
- UniSTS:95148

TNF (e-PCR), detects polymorphism
- UniSTS:479942

PMC150514P2 (e-PCR)
- UniSTS:271060

PMC97302P1 (e-PCR)
- UniSTS:273646

TNF (e-PCR), detects polymorphism
- UniSTS:264951

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor

Names: ATP-binding cassette, sub-family F (GCN20), member 1; TNF-a; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047149.1 → NP_001040614.1 tumor necrosis factor

See identical proteins and their annotated locations for NP_001040614.1

Status: PROVISIONAL

Source sequence(s)

U19850

UniProtKB/Swiss-Prot

P48094, Q5TM21, Q8HZD6

UniProtKB/TrEMBL

A0A0U5J6L8, G7MRI3, Q09H01

Related

ENSMMUP00000056761.1, ENSMMUT00000056699.2

Conserved Domains (1) summary

pfam00229
Location:102 → 233

TNF; TNF(tumor Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

NC_133409.1 Reference T2T-MMU8v2.0

Range

150752209..150754815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015135927.3 → XP_014991413.1 tumor necrosis factor isoform X1

Conserved Domains (1) summary

pfam00229
Location:105 → 236

TNF; TNF(Tumour Necrosis Factor) family