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Arhgap42 Rho GTPase activating protein 42 [ Mus musculus (house mouse) ]

Gene ID: 71544, updated on 17-Aug-2024

Summary

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Official Symbol
Arhgap42provided by MGI
Official Full Name
Rho GTPase activating protein 42provided by MGI
Primary source
MGI:MGI:1918794
See related
Ensembl:ENSMUSG00000050730 AllianceGenome:MGI:1918794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030420J04Rik
Summary
Enables GTPase activator activity. Acts upstream of or within negative regulation of Rho protein signal transduction; negative regulation of systemic arterial blood pressure; and negative regulation of vascular associated smooth muscle contraction. Orthologous to human ARHGAP42 (Rho GTPase activating protein 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.1), limb E14.5 (RPKM 6.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A1; 9 2.46 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (8992508..9239032, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (8992507..9239027, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 6 Neighboring gene STARR-seq mESC enhancer starr_23249 Neighboring gene predicted gene, 32014 Neighboring gene STARR-seq mESC enhancer starr_23250 Neighboring gene STARR-seq mESC enhancer starr_23251 Neighboring gene STARR-seq mESC enhancer starr_23252 Neighboring gene STARR-seq mESC enhancer starr_23253 Neighboring gene STARR-seq mESC enhancer starr_23254 Neighboring gene STARR-seq mESC enhancer starr_23255 Neighboring gene progesterone receptor Neighboring gene STARR-seq mESC enhancer starr_23256 Neighboring gene STARR-seq mESC enhancer starr_23257 Neighboring gene STARR-seq mESC enhancer starr_23258 Neighboring gene STARR-seq mESC enhancer starr_23259 Neighboring gene predicted gene, 16833 Neighboring gene predicted gene, 51662 Neighboring gene predicted gene, 22815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo. Dee RA, et al. Cells, 2020 Apr 22. PMID 32331391, Free PMC Article
  2. ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility. Luo W, et al. J Cell Sci, 2017 Jul 15. PMID 28584191, Free PMC Article
  3. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. Bai X, et al. J Clin Invest, 2017 Feb 1. PMID 28112683, Free PMC Article
  4. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Bai X, et al. Nat Commun, 2013. PMID 24335996, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo.
    Title: Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo.
  2. Phosphorylation of ARHGAP42 Tyr-376 is revealed as a novel regulatory event by which Src can affect actin dynamics through RhoA inhibition.
    Title: ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility.
  3. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding
    Title: Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
  4. GRAF3 is expressed in a smooth muscle-restricted fashion.
    Title: The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of systemic arterial blood pressure IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 42
Names
VRho GTPase activating protein 42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372563.1 → NP_001359492.1  rho GTPase-activating protein 42 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (4) summary
    cd07634
    Location:19 → 225
    BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
    cd12066
    Location:821 → 875
    SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
    cd01249
    Location:267 → 376
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:369 → 567
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. NM_001372564.1 → NP_001359493.1  rho GTPase-activating protein 42 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (4) summary
    cd07634
    Location:19 → 225
    BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
    cd12066
    Location:800 → 854
    SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
    cd01249
    Location:267 → 376
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:369 → 567
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  3. NM_001372565.1 → NP_001359494.1  rho GTPase-activating protein 42 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (3) summary
    cd01249
    Location:267 → 376
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:369 → 515
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. NM_001372566.1 → NP_001359495.1  rho GTPase-activating protein 42 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (3) summary
    cd01249
    Location:233 → 342
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:335 → 481
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19 → 191
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. NM_001372567.1 → NP_001359496.1  rho GTPase-activating protein 42 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (2) summary
    cd01249
    Location:267 → 375
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. NM_001372568.1 → NP_001359497.1  rho GTPase-activating protein 42 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (1) summary
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. NM_001372569.1 → NP_001359498.1  rho GTPase-activating protein 42 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (1) summary
    cl12013
    Location:19 → 201
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  8. NM_001372570.1 → NP_001359499.1  rho GTPase-activating protein 42 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (1) summary
    cl12013
    Location:19 → 193
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. NM_027823.2 → NP_082099.1  rho GTPase-activating protein 42 isoform 3

    See identical proteins and their annotated locations for NP_082099.1

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Consensus CDS
    CCDS52720.1
    UniProtKB/Swiss-Prot
    B2RQE8
    Related
    ENSMUSP00000091419.5, ENSMUST00000093893.12
    Conserved Domains (4) summary
    cd12066
    Location:787 → 841
    SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
    cd01249
    Location:233 → 342
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:335 → 533
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19 → 191
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    8992508..9239032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RQE8.1 GenPept UniProtKB/Swiss-Prot:B2RQE8

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