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Arhgap42 Rho GTPase activating protein 42 [ Mus musculus (house mouse) ]

Gene ID: 71544, updated on 26-Sep-2022

Summary

Official Symbol
Arhgap42provided by MGI
Official Full Name
Rho GTPase activating protein 42provided by MGI
Primary source
MGI:MGI:1918794
See related
Ensembl:ENSMUSG00000050730 AllianceGenome:MGI:1918794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030420J04Rik
Summary
Enables GTPase activator activity. Acts upstream of or within negative regulation of Rho protein signal transduction; negative regulation of systemic arterial blood pressure; and negative regulation of vascular associated smooth muscle contraction. Orthologous to human ARHGAP42 (Rho GTPase activating protein 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.1), limb E14.5 (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

See Arhgap42 in Genome Data Viewer
Location:
9; 9 A1
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (8992508..9239032, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (8992507..9239027, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 6 Neighboring gene predicted gene, 32014 Neighboring gene progesterone receptor Neighboring gene predicted gene, 16833 Neighboring gene predicted gene, 51662 Neighboring gene predicted gene, 22815

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
rho GTPase-activating protein 42
Names
VRho GTPase activating protein 42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372563.1NP_001359492.1  rho GTPase-activating protein 42 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    UniProtKB/TrEMBL
    A0A8C6HXK0
    Conserved Domains (4) summary
    cd07634
    Location:19225
    BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
    cd12066
    Location:821875
    SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
    cd01249
    Location:267376
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:369567
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
  2. NM_001372564.1NP_001359493.1  rho GTPase-activating protein 42 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (4) summary
    cd07634
    Location:19225
    BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
    cd12066
    Location:800854
    SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
    cd01249
    Location:267376
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:369567
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
  3. NM_001372565.1NP_001359494.1  rho GTPase-activating protein 42 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (3) summary
    cd01249
    Location:267376
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:369515
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. NM_001372566.1NP_001359495.1  rho GTPase-activating protein 42 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (3) summary
    cd01249
    Location:233342
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:335481
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19191
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. NM_001372567.1NP_001359496.1  rho GTPase-activating protein 42 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (2) summary
    cd01249
    Location:267375
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:19225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. NM_001372568.1NP_001359497.1  rho GTPase-activating protein 42 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (1) summary
    cl12013
    Location:19225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. NM_001372569.1NP_001359498.1  rho GTPase-activating protein 42 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (1) summary
    cl12013
    Location:19201
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  8. NM_001372570.1NP_001359499.1  rho GTPase-activating protein 42 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Conserved Domains (1) summary
    cl12013
    Location:19193
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  9. NM_027823.2NP_082099.1  rho GTPase-activating protein 42 isoform 3

    See identical proteins and their annotated locations for NP_082099.1

    Status: VALIDATED

    Source sequence(s)
    AC113589, AC160964, AC162803
    Consensus CDS
    CCDS52720.1
    UniProtKB/Swiss-Prot
    B2RQE8
    UniProtKB/TrEMBL
    A0A8C6HWH0
    Related
    ENSMUSP00000091419.5, ENSMUST00000093893.12
    Conserved Domains (4) summary
    cd12066
    Location:787841
    SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
    cd01249
    Location:233342
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:335533
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19191
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    8992508..9239032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)