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Kazn kazrin, periplakin interacting protein [ Mus musculus (house mouse) ]

Gene ID: 71529, updated on 6-Jan-2023

Summary

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Official Symbol
Kaznprovided by MGI
Official Full Name
kazrin, periplakin interacting proteinprovided by MGI
Primary source
MGI:MGI:1918779
See related
Ensembl:ENSMUSG00000040606 AllianceGenome:MGI:1918779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kaz; Kazrin; 2310007B04Rik; 9030409G11Rik
Summary
Predicted to act upstream of or within keratinization. Predicted to be located in several cellular components, including cornified envelope; desmosome; and nuclear speck. Is expressed in several structures, including blastocyst; early embryo; extraembryonic component; genitourinary system; and primitive ventricle cardiac muscle. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 9.1), cerebellum adult (RPKM 6.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Kazn in Genome Data Viewer
Location:
4; 4 D3- E1
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141829701..142801231, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (142102390..142239401, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455G09 gene Neighboring gene transmembrane protein 51 Neighboring gene Tmem51 opposite strand 1 Neighboring gene predicted gene, 35581 Neighboring gene predicted gene, 35531 Neighboring gene predicted gene, 54267 Neighboring gene predicted gene, 42339 Neighboring gene predicted gene, 35752 Neighboring gene predicted gene, 42342 Neighboring gene predicted gene, 42340 Neighboring gene predicted gene, 42341 Neighboring gene microRNA 7021 Neighboring gene PR domain containing 2, with ZNF domain Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dynamics and unexpected localization of the plakin binding protein, kazrin, in mouse eggs and early embryos. Gallicano GI, et al. Dev Dyn, 2005 Sep. PMID 16086310
  2. Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. Groot KR, et al. J Cell Biol, 2004 Aug 30. PMID 15337775, Free PMC Article
  3. Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. Chhatriwala MK, et al. J Invest Dermatol, 2012 Aug. PMID 22513779, Free PMC Article
  4. Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. Youlten SE, et al. Nat Commun, 2021 May 5. PMID 33953184, Free PMC Article
  5. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within keratinization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cornified envelope ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kazrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109684.2 → NP_001103154.1  kazrin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663037, MF597748
    UniProtKB/Swiss-Prot
    Q69ZS8
    UniProtKB/TrEMBL
    G3UY74
    Related
    ENSMUSP00000133972.3, ENSMUST00000172864.9
    Conserved Domains (1) summary
    pfam13863
    Location:129 → 242
    DUF4200; Domain of unknown function (DUF4200)

  2. NM_001109685.2 → NP_001103155.1  kazrin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663037, BX537122
    Consensus CDS
    CCDS51350.1
    UniProtKB/Swiss-Prot
    Q69ZS8
    UniProtKB/TrEMBL
    A0A6P5PDA3
    Related
    ENSMUSP00000038835.4, ENSMUST00000036476.10
    Conserved Domains (1) summary
    TIGR02168
    Location:71 → 248
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_144531.4 → NP_653114.3  kazrin isoform 1

    See identical proteins and their annotated locations for NP_653114.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL663037, MF597748
    UniProtKB/Swiss-Prot
    Q69ZS8, Q8R1X4
    UniProtKB/TrEMBL
    Q8BJ43
    Related
    ENSMUSP00000116071.3, ENSMUST00000155023.9
    Conserved Domains (4) summary
    cd09564
    Location:447 → 516
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:526 → 590
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:612 → 683
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:2 → 245
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141829701..142801231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164437.1 → XP_036020330.1  kazrin isoform X2

    Conserved Domains (4) summary
    cd09564
    Location:535 → 604
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:614 → 678
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:700 → 771
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:69 → 333
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_036164436.1 → XP_036020329.1  kazrin isoform X1

    Conserved Domains (4) summary
    cd09564
    Location:536 → 605
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:615 → 679
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:701 → 772
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:69 → 333
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_036164443.1 → XP_036020336.1  kazrin isoform X6

    UniProtKB/Swiss-Prot
    Q8R1X4
    Conserved Domains (4) summary
    cd09564
    Location:447 → 516
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:526 → 590
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:612 → 683
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:2 → 245
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_036164441.1 → XP_036020334.1  kazrin isoform X5

    Conserved Domains (4) summary
    cd09564
    Location:448 → 517
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:527 → 591
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:613 → 684
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:2 → 245
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_036164438.1 → XP_036020331.1  kazrin isoform X3

    Conserved Domains (4) summary
    cd09564
    Location:454 → 523
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:533 → 597
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:619 → 690
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:8 → 251
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_036164439.1 → XP_036020332.1  kazrin isoform X4

    Conserved Domains (4) summary
    cd09564
    Location:453 → 522
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:532 → 596
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:618 → 689
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:8 → 251
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_036164442.1 → XP_036020335.1  kazrin isoform X6

    UniProtKB/Swiss-Prot
    Q8R1X4
    Conserved Domains (4) summary
    cd09564
    Location:447 → 516
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:526 → 590
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:612 → 683
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:2 → 245
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_036164440.1 → XP_036020333.1  kazrin isoform X5

    Conserved Domains (4) summary
    cd09564
    Location:448 → 517
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:527 → 591
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:613 → 684
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:2 → 245
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  9. XM_036164445.1 → XP_036020338.1  kazrin isoform X8

    Conserved Domains (4) summary
    cd09564
    Location:436 → 505
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:515 → 579
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:601 → 672
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:72 → 246
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  10. XM_036164444.1 → XP_036020337.1  kazrin isoform X7

    Conserved Domains (4) summary
    cd09564
    Location:437 → 506
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:516 → 580
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:602 → 673
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:72 → 246
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_036164449.1 → XP_036020342.1  kazrin isoform X12

    Conserved Domains (3) summary
    cd09564
    Location:120 → 189
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:199 → 263
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:285 → 356
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3

  12. XM_036164448.1 → XP_036020341.1  kazrin isoform X11

    Conserved Domains (1) summary
    COG1196
    Location:69 → 333
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  13. XM_036164447.1 → XP_036020340.1  kazrin isoform X10

    Conserved Domains (1) summary
    COG1196
    Location:69 → 333
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  14. XM_036164446.1 → XP_036020339.1  kazrin isoform X9

    Conserved Domains (1) summary
    COG1196
    Location:69 → 333
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_004941964.1 RNA Sequence

  2. XR_004941963.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZS8.2 GenPept UniProtKB/Swiss-Prot:Q69ZS8

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