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GRK3 G protein-coupled receptor kinase 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 714510, updated on 16-Jun-2026
Official Symbol
GRK3provided by VGNC
Official Full Name
G protein-coupled receptor kinase 3provided by VGNC
Primary source
VGNC:VGNC:73255
See related
Ensembl:ENSMMUG00000023790
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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See GRK3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 10 NC_133415.1 (25857528..26018280, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (25844075..26007820, complement)

Chromosome 10 - NC_133415.1Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like Neighboring gene myosin XVIIIB Neighboring gene uncharacterized LOC144331870 Neighboring gene tyrosine-protein kinase Yes-like Neighboring gene uncharacterized LOC114670384 Neighboring gene beta-crystallin B2 Neighboring gene piwi like RNA-mediated gene silencing 3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
G protein-coupled receptor kinase 3
Names
beta-adrenergic receptor kinase 2
XP_001104308.2
XP_028683763.1
XP_028683765.1

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RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133415.1 Reference T2T-MMU8v2.0

    Range
    25857528..26018280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028827932.2 → XP_028683765.1  G protein-coupled receptor kinase 3 isoform X3

    UniProtKB/TrEMBL
    F7HT93
    Related
    ENSMMUP00000064465.1
    Conserved Domains (3) summary
    cd01240
    Location:440 → 557
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd05633
    Location:72 → 417
    STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
    cl02565
    Location:1 → 73
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. XM_001104308.5 → XP_001104308.2  G protein-coupled receptor kinase 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5QM37, A0A5F7ZH17, A0ACM8R9U2, H9FQI6
    Related
    ENSMMUP00000049112.2
    Conserved Domains (3) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:553 → 670
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd05633
    Location:185 → 530
    STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3

  3. XM_028827930.2 → XP_028683763.1  G protein-coupled receptor kinase 3 isoform X2

    UniProtKB/TrEMBL
    F7HT93
    Conserved Domains (3) summary
    cd01240
    Location:485 → 602
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd05633
    Location:117 → 462
    STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
    cl02565
    Location:19 → 118
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein
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