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TNS1 tensin 1 [ Homo sapiens (human) ]

Gene ID: 7145, updated on 10-Jan-2020

Summary

Official Symbol
TNS1provided by HGNC
Official Full Name
tensin 1provided by HGNC
Primary source
HGNC:HGNC:11973
See related
Ensembl:ENSG00000079308 MIM:600076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155
Summary
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues See more
Orthologs

Genomic context

See TNS1 in Genome Data Viewer
Location:
2q35
Exon count:
45
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (217799588..218002995, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218664512..218808796, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 like 1 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 7557 Neighboring gene small nucleolar RNA, H/ACA box 115 Neighboring gene microRNA 6809 Neighboring gene VISTA enhancer hs1764 Neighboring gene uncharacterized LOC105373878 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene C-X-C motif chemokine receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
NHGRI GWA Catalog
Genome-wide association study identifies five loci associated with lung function.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88584, DKFZp586K0617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell-substrate junction assembly IEA
Inferred from Electronic Annotation
more info
 
fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tensin-1
Names
Matrix-remodelling-associated protein 6
matrix-remodelling associated 6
protein phosphatase 1, regulatory subunit 155

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308022.1NP_001294951.1  tensin-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB209238, AC009469, AF225896, AK300345, AK309785, BC051304, BC116187, BC116188, BQ045472
    Consensus CDS
    CCDS77529.1
    UniProtKB/Swiss-Prot
    Q9HBL0
    UniProtKB/TrEMBL
    B7Z6H8, E9PF55, Q0VG54, Q0VG55, Q59G71, Q86VB0
    Related
    ENSP00000408724.1, ENST00000419504.5
    Conserved Domains (4) summary
    cd09927
    Location:14461560
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:15821715
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  2. NM_001308023.2NP_001294952.1  tensin-1 isoform 3

    See identical proteins and their annotated locations for NP_001294952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC009469
    Consensus CDS
    CCDS77528.1
    UniProtKB/TrEMBL
    B2RU35, B7Z6H8, E9PGF5, Q0VG54, Q59G71, Q86VB0
    Related
    ENSP00000406016.1, ENST00000430930.5
    Conserved Domains (4) summary
    cd09927
    Location:14381553
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:15751708
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  3. NM_022648.6NP_072174.3  tensin-1 isoform 1

    See identical proteins and their annotated locations for NP_072174.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209238, AC009469, AF225896, AL706926, BC051304, BC126910, BQ045472
    Consensus CDS
    CCDS2407.1
    UniProtKB/Swiss-Prot
    Q9HBL0
    UniProtKB/TrEMBL
    A1L0S7, Q59G71, Q86VB0
    Related
    ENSP00000171887.4, ENST00000171887.8
    Conserved Domains (5) summary
    cd09927
    Location:14591574
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:15961729
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555944
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    217799588..218002995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453083.1XP_024308851.1  tensin-1 isoform X15

    Related
    ENSP00000498399.1, ENST00000651849.1
    Conserved Domains (6) summary
    cd09927
    Location:15631678
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:202317
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:17001833
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cl00040
    Location:3467
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam10409
    Location:304430
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:8971408
    Atrophin-1; Atrophin-1 family
  2. XM_024453079.1XP_024308847.1  tensin-1 isoform X12

    Conserved Domains (6) summary
    cd09927
    Location:17291844
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:202317
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:18661999
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cl00040
    Location:3467
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam10409
    Location:304430
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:7521167
    Atrophin-1; Atrophin-1 family
  3. XM_024453084.1XP_024308852.1  tensin-1 isoform X20

    Conserved Domains (5) summary
    cd09927
    Location:14591574
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:15961729
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555944
    Atrophin-1; Atrophin-1 family
  4. XM_024453078.1XP_024308846.1  tensin-1 isoform X11

    Conserved Domains (5) summary
    cd09927
    Location:15321647
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16691802
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555970
    Atrophin-1; Atrophin-1 family
  5. XM_017004812.1XP_016860301.1  tensin-1 isoform X11

    Conserved Domains (5) summary
    cd09927
    Location:15321647
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16691802
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555970
    Atrophin-1; Atrophin-1 family
  6. XM_011511723.2XP_011510025.1  tensin-1 isoform X16

    UniProtKB/TrEMBL
    E9PGF5
    Conserved Domains (4) summary
    cd09927
    Location:14381553
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:15751708
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  7. XM_017004811.1XP_016860300.1  tensin-1 isoform X11

    Conserved Domains (5) summary
    cd09927
    Location:15321647
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16691802
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555970
    Atrophin-1; Atrophin-1 family
  8. XM_024453082.1XP_024308850.1  tensin-1 isoform X14

    Conserved Domains (5) summary
    cd09927
    Location:16041719
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:17411874
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271042
    Atrophin-1; Atrophin-1 family
  9. XM_024453081.1XP_024308849.1  tensin-1 isoform X14

    Conserved Domains (5) summary
    cd09927
    Location:16041719
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:17411874
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271042
    Atrophin-1; Atrophin-1 family
  10. XM_024453080.1XP_024308848.1  tensin-1 isoform X13

    Conserved Domains (5) summary
    cd09927
    Location:16691784
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:142257
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:18061939
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:244370
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6921107
    Atrophin-1; Atrophin-1 family
  11. XM_024453077.1XP_024308845.1  tensin-1 isoform X10

    Conserved Domains (5) summary
    cd09927
    Location:14511566
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:15881721
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555944
    Atrophin-1; Atrophin-1 family
  12. XM_024453072.1XP_024308840.1  tensin-1 isoform X5

    Conserved Domains (5) summary
    cd09927
    Location:15481663
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:16851818
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:571986
    Atrophin-1; Atrophin-1 family
  13. XM_024453076.1XP_024308844.1  tensin-1 isoform X9

    Conserved Domains (5) summary
    cd09927
    Location:15101625
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16471780
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:8441355
    Atrophin-1; Atrophin-1 family
  14. XM_024453075.1XP_024308843.1  tensin-1 isoform X8

    Conserved Domains (5) summary
    cd09927
    Location:15231638
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16601793
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271016
    Atrophin-1; Atrophin-1 family
  15. XM_024453069.1XP_024308837.1  tensin-1 isoform X2

    Conserved Domains (5) summary
    cd09927
    Location:15751690
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:17121845
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271016
    Atrophin-1; Atrophin-1 family
  16. XM_024453074.1XP_024308842.1  tensin-1 isoform X7

    Conserved Domains (5) summary
    cd09927
    Location:15391654
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16761809
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271042
    Atrophin-1; Atrophin-1 family
  17. XM_024453071.1XP_024308839.1  tensin-1 isoform X4

    Conserved Domains (5) summary
    cd09927
    Location:15521667
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16891822
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271042
    Atrophin-1; Atrophin-1 family
  18. XM_024453073.1XP_024308841.1  tensin-1 isoform X6

    Conserved Domains (5) summary
    cd09927
    Location:15471662
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16841817
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:8451457
    Atrophin-1; Atrophin-1 family
  19. XM_024453070.1XP_024308838.1  tensin-1 isoform X3

    Conserved Domains (5) summary
    cd09927
    Location:15601675
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:16971830
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271042
    Atrophin-1; Atrophin-1 family
  20. XM_024453068.1XP_024308836.1  tensin-1 isoform X1

    Conserved Domains (5) summary
    cd09927
    Location:16041718
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:17401873
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6271042
    Atrophin-1; Atrophin-1 family
  21. XM_017004814.1XP_016860303.1  tensin-1 isoform X18

  22. XM_017004815.1XP_016860304.1  tensin-1 isoform X18

  23. XM_017004813.2XP_016860302.1  tensin-1 isoform X17

    Related
    ENSP00000480559.1, ENST00000615025.4
  24. XM_017004816.2XP_016860305.1  tensin-1 isoform X19

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