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TNS1 tensin 1 [ Homo sapiens (human) ]

Gene ID: 7145, updated on 6-Sep-2022

Summary

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Official Symbol
TNS1provided by HGNC
Official Full Name
tensin 1provided by HGNC
Primary source
HGNC:HGNC:11973
See related
Ensembl:ENSG00000079308 MIM:600076; AllianceGenome:HGNC:11973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155
Summary
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues See more
Orthologs
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Genomic context

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See TNS1 in Genome Data Viewer
Location:
2q35
Exon count:
48
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (217799791..218033982, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218283109..218487855, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218664514..218867718, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 like 1 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 7557 Neighboring gene small nucleolar RNA, H/ACA box 115 Neighboring gene Sharpr-MPRA regulatory region 15318 Neighboring gene microRNA 6809 Neighboring gene VISTA enhancer hs1764 Neighboring gene uncharacterized LOC124905960 Neighboring gene TNS1 antisense RNA 1 Neighboring gene uncharacterized LOC124907982 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients. Walton NI, et al. Physiol Rep, 2021 Jun. PMID 34086412, Free PMC Article
  2. MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression. Chang KC, et al. Nat Commun, 2020 Dec 22. PMID 33353933, Free PMC Article
  3. Tensin1 expression and function in chronic obstructive pulmonary disease. Stylianou P, et al. Sci Rep, 2019 Dec 12. PMID 31831813, Free PMC Article
  4. Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases. Wu ZY, et al. Cell Death Dis, 2019 Nov 18. PMID 31740667, Free PMC Article
  5. Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation. Bernau K, et al. Am J Respir Cell Mol Biol, 2017 Apr. PMID 28005397, Free PMC Article

See all (58) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.
    Title: Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.
  2. miR-31-5p modulates cell progression in lung adenocarcinoma through TNS1/p53 axis.
    Title: miR-31-5p modulates cell progression in lung adenocarcinoma through TNS1/p53 axis.
  3. Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients.
    Title: Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients.
  4. miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway.
    Title: miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway.
  5. LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis.
    Title: LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis.
  6. MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
    Title: MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
  7. Tensin1 expression and function in chronic obstructive pulmonary disease.
    Title: Tensin1 expression and function in chronic obstructive pulmonary disease.
  8. Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases.
    Title: Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases.
  9. Hic-5 is a crucial regulator of extracellular matrix remodeling in Cancer-associated fibroblasts by promoting fibrillar adhesion formation through a novel interaction with tensin1.
    Title: Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1.
  10. miR-548j functions as a metastasis-promoting miRNA to regulate breast cancer cell invasion and metastasis by targeting Tensin1 and activating Cdc42.
    Title: MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
EBI GWAS Catalog
Genome-wide association study identifies five loci associated with lung function.
EBI GWAS Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC88584, DKFZp586K0617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast migration IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tensin-1
Names
Matrix-remodelling-associated protein 6
matrix-remodelling associated 6
protein phosphatase 1, regulatory subunit 155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308022.2 → NP_001294951.1  tensin-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB209238, AC009469, AF225896, AK300345, AK309785, BC051304, BC116187, BC116188, BQ045472
    Consensus CDS
    CCDS77529.1
    UniProtKB/Swiss-Prot
    Q9HBL0
    UniProtKB/TrEMBL
    B7Z6H8, E9PF55, Q0VG54, Q0VG55, Q59G71, Q86VB0
    Related
    ENSP00000408724.1, ENST00000419504.5
    Conserved Domains (4) summary
    cd09927
    Location:1446 → 1560
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77 → 192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:1582 → 1715
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179 → 305
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  2. NM_001308023.2 → NP_001294952.1  tensin-1 isoform 3

    See identical proteins and their annotated locations for NP_001294952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC009469
    Consensus CDS
    CCDS77528.1
    UniProtKB/TrEMBL
    A0A087WWW7, B2RU35, B7Z6H8, E9PGF5, Q0VG54, Q59G71, Q86VB0
    Related
    ENSP00000480559.2, ENST00000615025.5
    Conserved Domains (4) summary
    cd09927
    Location:1438 → 1553
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:77 → 192
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:1575 → 1708
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179 → 305
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  3. NM_001387777.1 → NP_001374706.1  tensin-1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009469, AC010136
    UniProtKB/TrEMBL
    A0A804HI61
    Related
    ENSP00000506917.1, ENST00000682258.1
    Conserved Domains (6) summary
    cd09927
    Location:1563 → 1678
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:897 → 1408
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1700 → 1833
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14560
    Location:139 → 297
    PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1
    pfam10409
    Location:304 → 430
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20888
    Location:16 → 72
    C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins

  4. NM_022648.7 → NP_072174.3  tensin-1 isoform 1

    See identical proteins and their annotated locations for NP_072174.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209238, AC009469, AF225896, AL706926, BC051304, BC126910, BQ045472
    Consensus CDS
    CCDS2407.1
    UniProtKB/Swiss-Prot
    Q6IPI5, Q9HBL0
    UniProtKB/TrEMBL
    A1L0S7, Q59G71, Q86VB0
    Related
    ENSP00000171887.4, ENST00000171887.8
    Conserved Domains (5) summary
    cd09927
    Location:1459 → 1574
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77 → 192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:1596 → 1729
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179 → 305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555 → 944
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    217799791..218033982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445637.1 → XP_047301593.1  tensin-1 isoform X2

  2. XM_047445644.1 → XP_047301600.1  tensin-1 isoform X12

    UniProtKB/TrEMBL
    A0A2R8Y4T1
    Related
    ENSP00000493967.1, ENST00000646520.1

  3. XM_047445639.1 → XP_047301595.1  tensin-1 isoform X6

  4. XM_047445638.1 → XP_047301594.1  tensin-1 isoform X3

  5. XM_047445636.1 → XP_047301592.1  tensin-1 isoform X1

  6. XM_047445645.1 → XP_047301601.1  tensin-1 isoform X13

  7. XM_047445642.1 → XP_047301598.1  tensin-1 isoform X10

  8. XM_047445640.1 → XP_047301596.1  tensin-1 isoform X8

  9. XM_024453079.2 → XP_024308847.1  tensin-1 isoform X5

    Conserved Domains (5) summary
    cd09927
    Location:1729 → 1844
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:752 → 1167
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1866 → 1999
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14560
    Location:139 → 297
    PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1
    cl00040
    Location:34 → 67
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  10. XM_047445641.1 → XP_047301597.1  tensin-1 isoform X9

  11. XM_024453078.2 → XP_024308846.2  tensin-1 isoform X4

  12. XM_024453084.2 → XP_024308852.1  tensin-1 isoform X22

    UniProtKB/Swiss-Prot
    Q6IPI5
    Conserved Domains (5) summary
    cd09927
    Location:1459 → 1574
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77 → 192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:1596 → 1729
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179 → 305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:555 → 944
    Atrophin-1; Atrophin-1 family

  13. XM_047445646.1 → XP_047301602.1  tensin-1 isoform X14

  14. XM_024453081.2 → XP_024308849.1  tensin-1 isoform X11

    Conserved Domains (5) summary
    cd09927
    Location:1604 → 1719
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:77 → 192
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:1741 → 1874
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:179 → 305
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:627 → 1042
    Atrophin-1; Atrophin-1 family

  15. XM_047445647.1 → XP_047301603.1  tensin-1 isoform X15

  16. XM_024453080.2 → XP_024308848.1  tensin-1 isoform X7

    Conserved Domains (5) summary
    cd09927
    Location:1669 → 1784
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:142 → 257
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:1806 → 1939
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:244 → 370
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:692 → 1107
    Atrophin-1; Atrophin-1 family

  17. XM_047445643.1 → XP_047301599.1  tensin-1 isoform X11

  18. XM_047445650.1 → XP_047301606.1  tensin-1 isoform X20

  19. XM_047445648.1 → XP_047301604.1  tensin-1 isoform X18

  20. XM_047445649.1 → XP_047301605.1  tensin-1 isoform X19

  21. XM_017004814.2 → XP_016860303.1  tensin-1 isoform X17

  22. XM_047445651.1 → XP_047301607.1  tensin-1 isoform X21

  23. XM_017004815.2 → XP_016860304.1  tensin-1 isoform X17

  24. XM_017004813.3 → XP_016860302.1  tensin-1 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    218283109..218487855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018274.2: Suppressed sequence

    Description
    NM_018274.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBL0.2 GenPept UniProtKB/Swiss-Prot:Q9HBL0

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