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Foxn3 forkhead box N3 [ Mus musculus (house mouse) ]

Gene ID: 71375, updated on 5-Jan-2023

Summary

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Official Symbol
Foxn3provided by MGI
Official Full Name
forkhead box N3provided by MGI
Primary source
MGI:MGI:1918625
See related
Ensembl:ENSMUSG00000033713 AllianceGenome:MGI:1918625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ches1; Ches1l; HTLFL1; 5430426H20Rik
Summary
Predicted to enable DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Acts upstream of or within craniofacial suture morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; immune system; peripheral nervous system; and sensory organ. Orthologous to human FOXN3 (forkhead box N3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.2), bladder adult (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Foxn3 in Genome Data Viewer
Location:
12; 12 E
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (99156340..99529926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (99190081..99563667, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40554 Neighboring gene ribosomal protein L30, pseudogene 8 Neighboring gene RIKEN cDNA 4930474N09 gene Neighboring gene centromere protein W pseudogene Neighboring gene RIKEN cDNA 3300002A11 gene Neighboring gene VISTA enhancer mm12 Neighboring gene predicted gene, 46371 Neighboring gene predicted gene, 51999 Neighboring gene predicted gene, 26839 Neighboring gene predicted gene, 53755 Neighboring gene predicted gene, 35644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of retinal amacrine cell generation by miR-216b and Foxn3. Zhang H, et al. Development, 2022 Jan 15. PMID 34919141, Free PMC Article
  2. A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Karanth S, et al. Cell Rep, 2018 Jul 10. PMID 29996093, Free PMC Article
  3. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer. Li Q, et al. PLoS One, 2012. PMID 23133627, Free PMC Article
  4. Characterization of mouse and human nude genes. Schorpp M, et al. Immunogenetics, 1997. PMID 9321431
  5. Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Samaan G, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20691664

See all (33) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of retinal amacrine cell generation by miR-216b and Foxn3.
    Title: Regulation of retinal amacrine cell generation by miR-216b and Foxn3.
  2. liver FOXN3 and glucagon control fasting glucose.
    Title: A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.
  3. MIRN574 microRNA, mouse/*METAB
    Title: MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer.
  4. the Foxn3 mutation leads to partial embryonic and postnatal lethality, growth retardation, eye formation defects, dental anomalies and craniofacial defects.
    Title: Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC36260, MGC107530

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within craniofacial suture morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
forkhead box protein N3
Names
checkpoint suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183186.2 → NP_899009.2  forkhead box protein N3

    See identical proteins and their annotated locations for NP_899009.2

    Status: VALIDATED

    Source sequence(s)
    AI448353, AK046748, BE623611, BY717160
    Consensus CDS
    CCDS26103.1
    UniProtKB/Swiss-Prot
    Q499D0, Q9CU83
    UniProtKB/TrEMBL
    A0A6P7RPN9
    Related
    ENSMUSP00000082189.2, ENSMUST00000085108.8
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    99156340..99529926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516239.4 → XP_006516302.1  forkhead box protein N3 isoform X3

    See identical proteins and their annotated locations for XP_006516302.1

    UniProtKB/Swiss-Prot
    Q499D0, Q9CU83
    UniProtKB/TrEMBL
    A0A6P7RPN9
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  2. XM_006516232.5 → XP_006516295.1  forkhead box protein N3 isoform X1

    See identical proteins and their annotated locations for XP_006516295.1

    UniProtKB/TrEMBL
    A0A6P7RWX3
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  3. XM_030246927.2 → XP_030102787.1  forkhead box protein N3 isoform X2

    UniProtKB/TrEMBL
    A0A6P5R0K2
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  4. XM_036157616.1 → XP_036013509.1  forkhead box protein N3 isoform X3

    UniProtKB/Swiss-Prot
    Q9CU83
    UniProtKB/TrEMBL
    A0A6P7RPN9
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  5. XM_036157615.1 → XP_036013508.1  forkhead box protein N3 isoform X2

    UniProtKB/TrEMBL
    A0A6P5R0K2
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  6. XM_030246925.2 → XP_030102785.1  forkhead box protein N3 isoform X1

    UniProtKB/TrEMBL
    A0A6P7RWX3
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  7. XM_030246929.2 → XP_030102789.1  forkhead box protein N3 isoform X3

    UniProtKB/Swiss-Prot
    Q9CU83
    UniProtKB/TrEMBL
    A0A6P7RPN9
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  8. XM_030246928.1 → XP_030102788.1  forkhead box protein N3 isoform X2

    UniProtKB/TrEMBL
    A0A6P5R0K2
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  9. XM_006516233.3 → XP_006516296.1  forkhead box protein N3 isoform X1

    See identical proteins and their annotated locations for XP_006516296.1

    UniProtKB/TrEMBL
    A0A6P7RWX3
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  10. XM_036157617.1 → XP_036013510.1  forkhead box protein N3 isoform X3

    UniProtKB/Swiss-Prot
    Q9CU83
    UniProtKB/TrEMBL
    A0A6P7RPN9
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  11. XM_030246926.1 → XP_030102786.1  forkhead box protein N3 isoform X1

    UniProtKB/TrEMBL
    A0A6P7RWX3
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  12. XM_006516236.5 → XP_006516299.1  forkhead box protein N3 isoform X1

    See identical proteins and their annotated locations for XP_006516299.1

    UniProtKB/TrEMBL
    A0A6P7RWX3
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  13. XM_006516240.3 → XP_006516303.1  forkhead box protein N3 isoform X3

    See identical proteins and their annotated locations for XP_006516303.1

    UniProtKB/Swiss-Prot
    Q499D0, Q9CU83
    UniProtKB/TrEMBL
    A0A6P7RPN9
    Related
    ENSMUSP00000135082.2, ENSMUST00000177451.8
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  14. XM_006516234.3 → XP_006516297.1  forkhead box protein N3 isoform X1

    See identical proteins and their annotated locations for XP_006516297.1

    UniProtKB/TrEMBL
    A0A6P7RWX3
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  15. XM_017315205.2 → XP_017170694.1  forkhead box protein N3 isoform X2

    UniProtKB/TrEMBL
    A0A6P5R0K2
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

  16. XM_036157614.1 → XP_036013507.1  forkhead box protein N3 isoform X1

    UniProtKB/TrEMBL
    A0A6P7RWX3
    Conserved Domains (1) summary
    cd20059
    Location:114 → 203
    FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499D0.1 GenPept UniProtKB/Swiss-Prot:Q499D0

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