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CHEK2 checkpoint kinase 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 713668, updated on 17-May-2019

Summary

Official Symbol
CHEK2provided by VGNC
Official Full Name
checkpoint kinase 2provided by VGNC
See related
Ensembl:ENSMMUG00000020486
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs

Genomic context

See CHEK2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (22804832..22859276)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (70542885..70597383, complement)
Build 1.2 previous assembly Mmul_051212 (GCF_000002255.3) 10 NC_007867.1 (72519261..72573281, complement)

Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 117 Neighboring gene X-box binding protein 1 Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene uncharacterized LOC114670379 Neighboring gene phosphatidylinositol transfer protein beta

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • DNA damage-induced cell cycle checkpoints, organism-specific biosystem (from KEGG)
    DNA damage-induced cell cycle checkpoints, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • DNA damage-induced cell cycle checkpoints, conserved biosystem (from KEGG)
    DNA damage-induced cell cycle checkpoints, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

Markers

Homology

General protein information

Preferred Names
serine/threonine-protein kinase Chk2
Names
CHK2 checkpoint homolog
XP_015005469.1

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041763.1 Reference Mmul_10 Primary Assembly

    Range
    22804832..22859276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015149983.2XP_015005469.1  serine/threonine-protein kinase Chk2

    UniProtKB/TrEMBL
    F6ST42
    Related
    ENSMMUP00000037143.2
    Conserved Domains (2) summary
    cd00060
    Location:93201
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:213486
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

RNA

  1. XR_003719924.1 RNA Sequence

  2. XR_003719925.1 RNA Sequence

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