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TNNI1 troponin I1, slow skeletal type [ Homo sapiens (human) ]

Gene ID: 7135, updated on 7-Jun-2020

Summary

Official Symbol
TNNI1provided by HGNC
Official Full Name
troponin I1, slow skeletal typeprovided by HGNC
Primary source
HGNC:HGNC:11945
See related
Ensembl:ENSG00000159173 MIM:191042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNN1; SSTNI
Summary
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 22.0), prostate (RPKM 20.7) and 2 other tissues See more
Orthologs

Genomic context

See TNNI1 in Genome Data Viewer
Location:
1q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (201403784..201421730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201372895..201390874, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ladinin 1 Neighboring gene uncharacterized LOC101929343 Neighboring gene uncharacterized LOC101929367 Neighboring gene pleckstrin homology like domain family A member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp451O223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle filament sliding TAS
Traceable Author Statement
more info
 
regulation of striated muscle contraction NAS
Non-traceable Author Statement
more info
PubMed 
skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transition between fast and slow fiber IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
troponin I, slow skeletal muscle
Names
troponin I type 1 (skeletal, slow)
troponin I, slow-twitch isoform

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016649.2 RefSeqGene

    Range
    5017..22963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003281.4NP_003272.3  troponin I, slow skeletal muscle

    See identical proteins and their annotated locations for NP_003272.3

    Status: REVIEWED

    Source sequence(s)
    AC096677, AL832006, BC012600
    Consensus CDS
    CCDS1411.1
    UniProtKB/Swiss-Prot
    P19237
    Related
    ENSP00000354488.4, ENST00000361379.9
    Conserved Domains (1) summary
    pfam00992
    Location:15146
    Troponin; Troponin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    201403784..201421730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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