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TNFAIP6 TNF alpha induced protein 6 [ Homo sapiens (human) ]

Gene ID: 7130, updated on 20-Jan-2019

Summary

Official Symbol
TNFAIP6provided by HGNC
Official Full Name
TNF alpha induced protein 6provided by HGNC
Primary source
HGNC:HGNC:11898
See related
Ensembl:ENSG00000123610 MIM:600410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG6; TSG-6
Summary
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
Expression
Biased expression in appendix (RPKM 17.8), gall bladder (RPKM 12.0) and 11 other tissues See more
Orthologs

Genomic context

See TNFAIP6 in Genome Data Viewer
Location:
2q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (151357592..151380048)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (152214106..152236562)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985827 Neighboring gene N-myc and STAT interactor Neighboring gene uncharacterized LOC101929319 Neighboring gene microRNA 4773-1 Neighboring gene microRNA 4773-2 Neighboring gene RNA, 7SL, cytoplasmic 124, pseudogene Neighboring gene replication timing regulatory factor 1 Neighboring gene nebulin Neighboring gene NEB-ARL5A intergenic CAGE-defined B cell enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) in human B cells PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) in primary human brain microvascular endothelial cells PubMed
tat HIV-1 and the viral protein Tat modulate the expression of tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) in immature dendritic cells and monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
ovulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor-inducible gene 6 protein
Names
TNF-stimulated gene 6 protein
hyaluronate-binding protein
tumor necrosis factor alpha-inducible protein 6
tumor necrosis factor, alpha induced protein 6
tumor necrosis factor-stimulated gene-6 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007115.4NP_009046.2  tumor necrosis factor-inducible gene 6 protein precursor

    See identical proteins and their annotated locations for NP_009046.2

    Status: REVIEWED

    Source sequence(s)
    AC009311, AU102580, BC030205
    Consensus CDS
    CCDS2193.1
    UniProtKB/Swiss-Prot
    P98066
    Related
    ENSP00000243347.3, ENST00000243347.4
    Conserved Domains (2) summary
    cd03515
    Location:36128
    Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...
    pfam00431
    Location:135244
    CUB; CUB domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    151357592..151380048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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