Crnde colorectal neoplasia differentially expressed (non-protein coding) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crndeprovided by MGI
Official Full Name: colorectal neoplasia differentially expressed (non-protein coding)provided by MGI
Primary source: MGI:MGI:1918546
See related: Ensembl:ENSMUSG00000031736 AllianceGenome:MGI:1918546
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933436C20Rik
Summary: Acts upstream of or within positive regulation of gene expression. Is expressed in forebrain and retina. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 11.0), CNS E11.5 (RPKM 9.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 C5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (93052659..93082748, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (92326031..92356120, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs.
Title: lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs.
LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis.
Title: LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis.
LncRNA CRNDE inhibits cardiomyocytes apoptosis by YAP1 in myocardial ischaemia/reperfusion injury.
Title: LncRNA CRNDE inhibits cardiomyocytes apoptosis by YAP1 in myocardial ischaemia/reperfusion injury.
LncRNA CRNDE is activated by SP1 and promotes osteosarcoma proliferation, invasion, and epithelial-mesenchymal transition via Wnt/beta-catenin signaling pathway.
Title: LncRNA CRNDE is activated by SP1 and promotes osteosarcoma proliferation, invasion, and epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway.
The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/beta-catenin signaling pathway in mice.
Title: The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice.
Effect of lncRNA CRNDE on sepsis-related kidney injury through the TLR3/NF-kappaB pathway.
Title: Effect of lncRNA CRNDE on sepsis-related kidney injury through the TLR3/NF-κB pathway.
Overexpression of Crnde attenuated cardiac fibrosis and enhanced cardiac function in mice with DCM. Further, in vitro experiments showed that Crnde negatively regulates the myofibroblast differentiation of CFs. The expression of Crnde was activated by SMAD family member 3 (Smad3). Crnde also inhibited the transcriptional activation of Smad3 on target genes.
Title: Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Homology

Orthologs from Annotation Pipeline: 17 organisms have orthologs with human gene Crnde

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_033641.3 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AI413872, AK017076, CX205694

Related

ENSMUST00000034183.11
NR_110452.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two internal exons, contains an alternate internal exon, and differs in the 3' exon structure, resulting in a shorter transcript, compared to variant 1.

Source sequence(s)

AI413872, AK017076, CX205694