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F2 coagulation factor II, thrombin [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 712729, updated on 8-Apr-2026
Official Symbol
F2provided by VGNC
Official Full Name
coagulation factor II, thrombinprovided by VGNC
Primary source
VGNC:VGNC:72464
See related
Ensembl:ENSMMUG00000019674
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 14 NC_133419.1 (18861476..18880575, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (19022793..19041862, complement)

Chromosome 14 - NC_133419.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 5 Neighboring gene uncharacterized LOC144334256 Neighboring gene small nucleolar RNA SNORD67 Neighboring gene zinc finger protein 408 Neighboring gene uncharacterized LOC144334245 Neighboring gene Rho GTPase activating protein 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. cDNA cloning, protein structure modeling of rhesus monkey (Macaca mulatta) prothrombin. Qin SF, et al. Transplant Proc, 2008 Mar. PMID 18374141
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
prothrombin
NP_001098055.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104585.1 → NP_001098055.1  prothrombin precursor

    See identical proteins and their annotated locations for NP_001098055.1

    Status: PROVISIONAL

    Source sequence(s)
    EF057490
    UniProtKB/TrEMBL
    A0N064, F7CHB6, G7NDG8
    Related
    ENSMMUP00000079474.1, ENSMMUT00000103142.1
    Conserved Domains (5) summary
    smart00069
    Location:32 → 96
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:216 → 298
    KR; Kringle domain
    cd00108
    Location:113 → 194
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:369 → 621
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:322 → 368
    Thrombin_light; Thrombin light chain

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133419.1 Reference T2T-MMU8v2.0

    Range
    18861476..18880575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials