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TNNC2 troponin C2, fast skeletal type [ Homo sapiens (human) ]

Gene ID: 7125, updated on 7-Jun-2020

Summary

Official Symbol
TNNC2provided by HGNC
Official Full Name
troponin C2, fast skeletal typeprovided by HGNC
Primary source
HGNC:HGNC:11944
See related
Ensembl:ENSG00000101470 MIM:191039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAP85; CFAP85
Summary
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 45.9) and esophagus (RPKM 37.4) See more
Orthologs

Genomic context

See TNNC2 in Genome Data Viewer
Location:
20q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45823214..45833329, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44451853..44455953, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene deoxynucleotidyltransferase terminal interacting protein 1 Neighboring gene ubiquitin conjugating enzyme E2 C Neighboring gene sorting nexin family member 21 Neighboring gene acyl-CoA thioesterase 8 Neighboring gene zinc finger SWIM-type containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of troponin C type 2 (TNNC2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 protease hydrolyzes troponin C at amino acid residues 101-102 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
muscle filament sliding TAS
Traceable Author Statement
more info
 
regulation of muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
troponin complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
troponin C, skeletal muscle
Names
troponin C type 2 (fast)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003279.3NP_003270.1  troponin C, skeletal muscle

    See identical proteins and their annotated locations for NP_003270.1

    Status: REVIEWED

    Source sequence(s)
    AI080746, BU854061
    Consensus CDS
    CCDS13375.1
    UniProtKB/Swiss-Prot
    P02585
    Related
    ENSP00000361636.3, ENST00000372555.8
    Conserved Domains (1) summary
    cl25352
    Location:12156
    EFh_PEF; The penta-EF hand (PEF) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45823214..45833329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529031.2XP_011527333.1  troponin C, skeletal muscle isoform X1

    See identical proteins and their annotated locations for XP_011527333.1

    UniProtKB/TrEMBL
    C9J7T9
    Related
    ENSP00000361638.1, ENST00000372557.1
    Conserved Domains (2) summary
    cd15897
    Location:433
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:2141
    EFh_PEF; The penta-EF hand (PEF) family
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