U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nudt4 nudix hydrolase 4 [ Mus musculus (house mouse) ]

Gene ID: 71207, updated on 11-Apr-2024

Summary

Official Symbol
Nudt4provided by MGI
Official Full Name
nudix hydrolase 4provided by MGI
Primary source
MGI:MGI:1918457
See related
Ensembl:ENSMUSG00000020029 AllianceGenome:MGI:1918457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIPP2; DIPP-2; HDCMB47P; DIPP2beta; DIPP2alpha; 4933436C10Rik
Summary
Enables snoRNA binding activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human NUDT4 (nudix hydrolase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 90.4), colon adult (RPKM 66.3) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nudt4 in Genome Data Viewer
Location:
10 C2; 10 49.42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95382869..95400008, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95547007..95564146, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46239 Neighboring gene STARR-seq mESC enhancer starr_27642 Neighboring gene ubiquitin-conjugating enzyme E2N Neighboring gene STARR-positive B cell enhancer ABC_E8362 Neighboring gene STARR-seq mESC enhancer starr_27645 Neighboring gene microRNA 3058 Neighboring gene predicted gene, 33336 Neighboring gene STARR-seq mESC enhancer starr_27652 Neighboring gene anaphase promoting complex C subunit 15, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables bis(5'-adenosyl)-hexaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables bis(5'-adenosyl)-pentaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables diphosphoinositol-polyphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables diphosphoinositol-polyphosphate diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables endopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diadenosine hexaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diadenosine pentaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diphosphoinositol polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
diphosphoinositol polyphosphate phosphohydrolase 2
Names
diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2
nucleoside diphosphate-linked moiety X motif 4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
nudix motif 4
NP_001345925.1
NP_081998.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358996.1NP_001345925.1  diphosphoinositol polyphosphate phosphohydrolase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK017075, AK048062, BP753270, CJ208434
    Conserved Domains (1) summary
    cd04666
    Location:18137
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
  2. NM_027722.5NP_081998.3  diphosphoinositol polyphosphate phosphohydrolase 2 isoform 2

    See identical proteins and their annotated locations for NP_081998.3

    Status: VALIDATED

    Source sequence(s)
    AK017075, AK048062, CJ208434
    Consensus CDS
    CCDS24138.1
    UniProtKB/Swiss-Prot
    Q8BXB9, Q8R2U6, Q9D3T6
    UniProtKB/TrEMBL
    Q4FJR0
    Related
    ENSMUSP00000020217.6, ENSMUST00000020217.7
    Conserved Domains (1) summary
    cd04666
    Location:18136
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    95382869..95400008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)