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Zdhhc11 zinc finger, DHHC domain containing 11 [ Mus musculus (house mouse) ]

Gene ID: 71164, updated on 8-Feb-2024

Summary

Official Symbol
Zdhhc11provided by MGI
Official Full Name
zinc finger, DHHC domain containing 11provided by MGI
Primary source
MGI:MGI:1918414
See related
Ensembl:ENSMUSG00000069189 AllianceGenome:MGI:1918414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-11; Zdhhc20; 4933421L13Rik
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Located in endosome membrane. Is expressed in brain; male reproductive gland or organ; metanephros; and submandibular gland. Orthologous to several human genes including ZDHHC11 (zinc finger DHHC-type containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 13.3) See more
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Genomic context

See Zdhhc11 in Genome Data Viewer
Location:
13 C1; 13 40.15 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74111970..74141109)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73963851..73992990)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 13 Neighboring gene predicted gene, 57611 Neighboring gene bromodomain containing 9 Neighboring gene predicted gene, 41002 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene 15912 Neighboring gene tubulin polymerization promoting protein Neighboring gene integrin linked kinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC151180, MGC151184

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC11
Names
DHHC-containing protein 10
DHHC10(z11)
probable palmitoyltransferase ZDHHC11
zinc finger DHHC domain-containing protein 11
zinc finger, DHHC domain containing 20
NP_081980.1
XP_006517440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027704.3NP_081980.1  palmitoyltransferase ZDHHC11

    See identical proteins and their annotated locations for NP_081980.1

    Status: VALIDATED

    Source sequence(s)
    AK016865, BB012497, BC116807
    Consensus CDS
    CCDS36729.1
    UniProtKB/Swiss-Prot
    Q14AK4, Q5Y5T4
    UniProtKB/TrEMBL
    A0A1Y7VLH9
    Related
    ENSMUSP00000089075.5, ENSMUST00000091493.6
    Conserved Domains (1) summary
    pfam01529
    Location:123277
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. NR_153830.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT010471
    Related
    ENSMUST00000222487.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    74111970..74141109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517377.4XP_006517440.1  palmitoyltransferase ZDHHC11 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:8144
    DHHC; DHHC palmitoyltransferase