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DHFR dihydrofolate reductase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 711268, updated on 10-Feb-2026
Gene symbol
DHFR
Gene description
dihydrofolate reductase
See related
Ensembl:ENSMMUG00000018283
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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See DHFR in Genome Data Viewer
Location:
chromosome: 6
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 6 NC_133411.1 (86951087..86975397, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (77418930..77443376, complement)

Chromosome 6 - NC_133411.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL30-like Neighboring gene family with sequence similarity 151 member B Neighboring gene ankyrin repeat domain 34B Neighboring gene mutS homolog 3 Neighboring gene S-phase kinase-associated protein 1 pseudogene Neighboring gene uncharacterized LOC106998824 Neighboring gene Ras protein specific guanine nucleotide releasing factor 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dihydrofolate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
dihydrofolate reductase

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133411.1 Reference T2T-MMU8v2.0

    Range
    86951087..86975397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_078004949.1 → XP_077861075.1  dihydrofolate reductase isoform X6

    UniProtKB/TrEMBL
    F7HK25, G7MZ91, H9YW18

  2. XM_078004951.1 → XP_077861077.1  dihydrofolate reductase isoform X7

    UniProtKB/TrEMBL
    G7MZ91

  3. XM_078004947.1 → XP_077861073.1  dihydrofolate reductase isoform X4

    UniProtKB/TrEMBL
    G7MZ91

  4. XM_078004948.1 → XP_077861074.1  dihydrofolate reductase isoform X5

    UniProtKB/TrEMBL
    G7MZ91

  5. XM_015140343.3 → XP_014995829.1  dihydrofolate reductase isoform X7

    UniProtKB/TrEMBL
    G7MZ91
    Related
    ENSMMUP00000024036.4
    Conserved Domains (1) summary
    cd00209
    Location:12 → 147
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...

  6. XM_015140340.3 → XP_014995826.1  dihydrofolate reductase isoform X7

    UniProtKB/TrEMBL
    G7MZ91
    Conserved Domains (1) summary
    cd00209
    Location:12 → 147
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...

  7. XM_078004950.1 → XP_077861076.1  dihydrofolate reductase isoform X7

    UniProtKB/TrEMBL
    G7MZ91

  8. XM_078004946.1 → XP_077861072.1  dihydrofolate reductase isoform X3

    UniProtKB/TrEMBL
    G7MZ91

  9. XM_001110551.5 → XP_001110551.2  dihydrofolate reductase isoform X2

    Conserved Domains (1) summary
    cd00209
    Location:80 → 259
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...

  10. XM_078004945.1 → XP_077861071.1  dihydrofolate reductase isoform X1

Nucleotide Protein
Heading Accession and Version

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