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Sntg1 syntrophin, gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 71096, updated on 5-Mar-2024

Summary

Official Symbol
Sntg1provided by MGI
Official Full Name
syntrophin, gamma 1provided by MGI
Primary source
MGI:MGI:1918346
See related
Ensembl:ENSMUSG00000025909 AllianceGenome:MGI:1918346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SYN4; G1SYN; 4933426D16Rik
Summary
Predicted to enable protein C-terminus binding activity. Predicted to be located in cytoplasm; cytoskeleton; and ruffle membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Orthologous to human SNTG1 (syntrophin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.4) and 6 other tissues See more
Orthologs
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Genomic context

Location:
1 A1- A2; 1 2.08 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (8429963..9371882, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (8359739..9301657, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00135 Neighboring gene F-box protein 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00138 Neighboring gene predicted gene, 39589 Neighboring gene STARR-seq mESC enhancer starr_00139 Neighboring gene STARR-seq mESC enhancer starr_00140 Neighboring gene STARR-seq mESC enhancer starr_00143 Neighboring gene STARR-seq mESC enhancer starr_00144 Neighboring gene STARR-seq mESC enhancer starr_00146 Neighboring gene STARR-seq mESC enhancer starr_00148 Neighboring gene STARR-seq mESC enhancer starr_00149 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00150 Neighboring gene STARR-seq mESC enhancer starr_00151 Neighboring gene STARR-seq mESC enhancer starr_00153 Neighboring gene STARR-seq mESC enhancer starr_00156 Neighboring gene STARR-seq mESC enhancer starr_00154 Neighboring gene RING-box protein 2 pseudogene Neighboring gene RING-box protein 2 pseudogene Neighboring gene mitochondrial import inner membrane translocase subunit Tim23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00157 Neighboring gene STARR-seq mESC enhancer starr_00158 Neighboring gene STARR-seq mESC enhancer starr_00159 Neighboring gene STARR-seq mESC enhancer starr_00160 Neighboring gene predicted gene, 30719 Neighboring gene predicted gene 6187

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
part_of dystrophin-associated glycoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-1-syntrophin
Names
syntrophin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290390.1NP_001277319.1  gamma-1-syntrophin isoform 2

    See identical proteins and their annotated locations for NP_001277319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC102786, AK038698, AK083241, CJ254355
    Consensus CDS
    CCDS69860.1
    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    UniProtKB/TrEMBL
    Q8C415
    Related
    ENSMUSP00000141839.2, ENSMUST00000191683.6
    Conserved Domains (2) summary
    smart00233
    Location:283388
    PH; Pleckstrin homology domain
    cd00992
    Location:55135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001290392.1NP_001277321.1  gamma-1-syntrophin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to isoform 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC102786, AK038698, AK083241, CJ254355
    UniProtKB/TrEMBL
    Q8CAI8
    Conserved Domains (1) summary
    smart00233
    Location:32137
    PH; Pleckstrin homology domain
  3. NM_001290393.1NP_001277322.1  gamma-1-syntrophin isoform 1

    See identical proteins and their annotated locations for NP_001277322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC102786, AF367759, AK038698, AK080034, AK083241, CJ254355
    Consensus CDS
    CCDS35509.1
    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    UniProtKB/TrEMBL
    E9Q0U6, Q8BNW6
    Conserved Domains (2) summary
    smart00233
    Location:284389
    PH; Pleckstrin homology domain
    cd00992
    Location:55136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_027671.5NP_081947.2  gamma-1-syntrophin isoform 1

    See identical proteins and their annotated locations for NP_081947.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC102786, AK038698, AK080034, AK083241, CJ254355
    Consensus CDS
    CCDS35509.1
    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    UniProtKB/TrEMBL
    E9Q0U6, Q8BNW6
    Related
    ENSMUSP00000118101.3, ENSMUST00000140295.8
    Conserved Domains (2) summary
    smart00233
    Location:284389
    PH; Pleckstrin homology domain
    cd00992
    Location:55136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    8429963..9371882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153661.1XP_036009554.1  gamma-1-syntrophin isoform X5

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    Conserved Domains (2) summary
    smart00233
    Location:236341
    PH; Pleckstrin homology domain
    cd00992
    Location:788
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_036153666.1XP_036009559.1  gamma-1-syntrophin isoform X7

    UniProtKB/TrEMBL
    Q8CAI8
    Conserved Domains (1) summary
    smart00233
    Location:32137
    PH; Pleckstrin homology domain
  3. XM_036153660.1XP_036009553.1  gamma-1-syntrophin isoform X4

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    Conserved Domains (2) summary
    smart00233
    Location:270375
    PH; Pleckstrin homology domain
    cd00992
    Location:55135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_017312321.2XP_017167810.1  gamma-1-syntrophin isoform X2

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    UniProtKB/TrEMBL
    Q8C415
    Related
    ENSMUSP00000122134.2, ENSMUST00000132064.8
    Conserved Domains (2) summary
    smart00233
    Location:283388
    PH; Pleckstrin homology domain
    cd00992
    Location:55135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_006495572.3XP_006495635.1  gamma-1-syntrophin isoform X3

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    Conserved Domains (2) summary
    smart00233
    Location:271376
    PH; Pleckstrin homology domain
    cd00992
    Location:55136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_036153664.1XP_036009557.1  gamma-1-syntrophin isoform X7

    UniProtKB/TrEMBL
    Q8CAI8
    Conserved Domains (1) summary
    smart00233
    Location:32137
    PH; Pleckstrin homology domain
  7. XM_036153658.1XP_036009551.1  gamma-1-syntrophin isoform X2

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    UniProtKB/TrEMBL
    Q8C415
    Conserved Domains (2) summary
    smart00233
    Location:283388
    PH; Pleckstrin homology domain
    cd00992
    Location:55135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_011238407.3XP_011236709.1  gamma-1-syntrophin isoform X1

    See identical proteins and their annotated locations for XP_011236709.1

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    UniProtKB/TrEMBL
    E9Q0U6, Q8BNW6
    Conserved Domains (2) summary
    smart00233
    Location:284389
    PH; Pleckstrin homology domain
    cd00992
    Location:55136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_036153662.1XP_036009555.1  gamma-1-syntrophin isoform X5

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    Conserved Domains (2) summary
    smart00233
    Location:236341
    PH; Pleckstrin homology domain
    cd00992
    Location:788
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. XM_017312320.3XP_017167809.1  gamma-1-syntrophin isoform X1

    UniProtKB/Swiss-Prot
    Q925E1, Q9D3Z5
    UniProtKB/TrEMBL
    E9Q0U6, Q8BNW6
    Related
    ENSMUSP00000111151.3, ENSMUST00000115488.3
    Conserved Domains (2) summary
    smart00233
    Location:284389
    PH; Pleckstrin homology domain
    cd00992
    Location:55136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_036153663.1XP_036009556.1  gamma-1-syntrophin isoform X6

    Conserved Domains (2) summary
    smart00233
    Location:191264
    PH; Pleckstrin homology domain
    cd00992
    Location:55136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_001778003.3 RNA Sequence