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GPR137B G protein-coupled receptor 137B [ Homo sapiens (human) ]

Gene ID: 7107, updated on 29-Mar-2020

Summary

Official Symbol
GPR137Bprovided by HGNC
Official Full Name
G protein-coupled receptor 137Bprovided by HGNC
Primary source
HGNC:HGNC:11862
See related
Ensembl:ENSG00000077585 MIM:604658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TM7SF1
Expression
Ubiquitous expression in kidney (RPKM 12.9), brain (RPKM 8.4) and 23 other tissues See more
Orthologs

Genomic context

See GPR137B in Genome Data Viewer
Location:
1q42.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (236142529..236213535)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236305832..236415314)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot MSTM1 Neighboring gene meiotic recombination hotspot MSTM2 Neighboring gene endoplasmic reticulum oxidoreductase 1 beta Neighboring gene RNA, U2 small nuclear 70, pseudogene Neighboring gene FKBP prolyl isomerase 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
integral membrane protein GPR137B
Names
transmembrane 7 superfamily member 1 (upregulated in kidney)
transmembrane 7 superfamily member 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003272.4NP_003263.1  integral membrane protein GPR137B

    See identical proteins and their annotated locations for NP_003263.1

    Status: VALIDATED

    Source sequence(s)
    AI634648, BC012100
    Consensus CDS
    CCDS1609.1
    UniProtKB/Swiss-Prot
    O60478
    Related
    ENSP00000355551.3, ENST00000366592.8
    Conserved Domains (1) summary
    TIGR03022
    Location:80191
    WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    236142529..236213535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002209.2XP_016857698.1  integral membrane protein GPR137B isoform X1

    Conserved Domains (1) summary
    TIGR03022
    Location:80191
    WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP
  2. XM_017002210.2XP_016857699.1  integral membrane protein GPR137B isoform X2

RNA

  1. XR_247039.4 RNA Sequence

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