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TSPAN6 tetraspanin 6 [ Homo sapiens (human) ]

Gene ID: 7105, updated on 18-Aug-2020

Summary

Official Symbol
TSPAN6provided by HGNC
Official Full Name
tetraspanin 6provided by HGNC
Primary source
HGNC:HGNC:11858
See related
Ensembl:ENSG00000000003 MIM:300191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T245; TM4SF6; TSPAN-6
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in colon (RPKM 15.1), ovary (RPKM 15.0) and 24 other tissues See more
Orthologs

Genomic context

See TSPAN6 in Genome Data Viewer
Location:
Xq22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (100627108..100637104, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (99882105..99892101, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373298 Neighboring gene tenomodulin Neighboring gene sushi repeat containing protein X-linked 2 Neighboring gene synaptotagmin like 4 Neighboring gene peptidylprolyl isomerase A pseudogene 89

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
tetraspanin-6
Names
A15 homolog
putative NF-kappa-B-activating protein 321
tetraspan TM4SF
tetraspanin TM4-D
transmembrane 4 superfamily member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012534.1 RefSeqGene

    Range
    4992..14690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278740.2NP_001265669.1  tetraspanin-6 isoform b precursor

    See identical proteins and their annotated locations for NP_001265669.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK309581, AL035608, DA147330, N64145
    UniProtKB/TrEMBL
    A0A024RCI0
    Conserved Domains (1) summary
    cd03161
    Location:24121
    TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. NM_001278741.1NP_001265670.1  tetraspanin-6 isoform b precursor

    See identical proteins and their annotated locations for NP_001265670.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AL035608, BI458635, CX868833, N64145
    UniProtKB/TrEMBL
    A0A024RCI0
    Conserved Domains (1) summary
    cd03161
    Location:24121
    TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  3. NM_001278742.1NP_001265671.1  tetraspanin-6 isoform c precursor

    See identical proteins and their annotated locations for NP_001265671.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and lacks an exon that results in an alternate 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL035608, BI458635, CN274931, N64145
    UniProtKB/TrEMBL
    A0A087WZU5
    Related
    ENSP00000482894.1, ENST00000614008.4
    Conserved Domains (1) summary
    cd03161
    Location:24121
    TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  4. NM_001278743.1NP_001265672.1  tetraspanin-6 isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB097016, AL035608, BI458635, DA038474, N64145
    Consensus CDS
    CCDS76001.1
    UniProtKB/Swiss-Prot
    O43657
    UniProtKB/TrEMBL
    A0A087WYV6
    Related
    ENSP00000482130.1, ENST00000612152.4
    Conserved Domains (1) summary
    cl02781
    Location:24107
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
  5. NM_003270.4NP_003261.1  tetraspanin-6 isoform a

    See identical proteins and their annotated locations for NP_003261.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL035608, AY358825, CX760536, N64145
    Consensus CDS
    CCDS14470.1
    UniProtKB/Swiss-Prot
    O43657
    Related
    ENSP00000362111.4, ENST00000373020.9
    Conserved Domains (1) summary
    pfam00335
    Location:17236
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    100627108..100637104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531018.1XP_011529320.1  tetraspanin-6 isoform X1

    See identical proteins and their annotated locations for XP_011529320.1

    UniProtKB/TrEMBL
    A0A024RCI0
    Conserved Domains (1) summary
    cd03161
    Location:24121
    TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
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