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NPAS2 neuronal PAS domain protein 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 710480, updated on 10-Feb-2026
Official Symbol
NPAS2provided by VGNC
Official Full Name
neuronal PAS domain protein 2provided by VGNC
Primary source
VGNC:VGNC:75378
See related
Ensembl:ENSMMUG00000009871
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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See NPAS2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 13 NC_133418.1 (8970456..9146308)
103 previous assembly Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (4628061..4803834)

Chromosome 13 - NC_133418.1Genomic Context describing neighboring genes Neighboring gene NANOG neighbor homeobox-like Neighboring gene uncharacterized LOC144333983 Neighboring gene uncharacterized LOC106993089 Neighboring gene TBC1 domain family member 8 Neighboring gene ribosomal protein L31 Neighboring gene BBSome-interacting protein 1 pseudogene

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Postweaning exposure to a high-fat diet is associated with alterations to the hepatic histone code in Japanese macaques. Suter MA, et al. Pediatr Res, 2013 Sep. PMID 23788059, Free PMC Article
  2. Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates. Suter M, et al. FASEB J, 2011 Feb. PMID 21097519, Free PMC Article
  3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altered Npas2 expression corresponds with a change in the histone code within the Npas2 promoter.
    Title: Postweaning exposure to a high-fat diet is associated with alterations to the hepatic histone code in Japanese macaques.
  2. Disruption of Npas2 is consistent with high-fat diet exposure in juvenile animals, regardless of in utero diet exposure. In summary, the data suggest that peripheral Npas2 expression is uniquely vulnerable to diet exposure.
    Title: Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CLOCK-BMAL transcription complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
neuronal PAS domain-containing protein 2

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RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133418.1 Reference T2T-MMU8v2.0

    Range
    8970456..9146308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028832241.2 → XP_028688074.2  neuronal PAS domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    G7NAS3

  2. XM_028832242.2 → XP_028688075.2  neuronal PAS domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    G7NAS3

  3. XM_077958874.1 → XP_077815000.1  neuronal PAS domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    G7NAS3

  4. XM_077958875.1 → XP_077815001.1  neuronal PAS domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    G7NAS3

  5. XM_028832243.2 → XP_028688076.2  neuronal PAS domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    G7NAS3
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials