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PLEK2 pleckstrin 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 710419, updated on 16-Jun-2026
Official Symbol
PLEK2provided by VGNC
Official Full Name
pleckstrin 2provided by VGNC
Primary source
VGNC:VGNC:76071
Locus tag
EGK_18304
See related
Ensembl:ENSMMUG00000021420
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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Try the new Transcripts and proteins table
See PLEK2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 7 NC_133412.1 (140554515..140581406, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (129517324..129544083, complement)

Chromosome 7 - NC_133412.1Genomic Context describing neighboring genes Neighboring gene protein associated with LIN7 1, MAGUK p55 family member Neighboring gene ATPase H+ transporting V1 subunit D Neighboring gene eukaryotic translation initiation factor 2 subunit alpha Neighboring gene ADP-ribosylation factor 1-like Neighboring gene uncharacterized LOC144330307

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pleckstrin-2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133412.1 Reference T2T-MMU8v2.0

    Range
    140554515..140581406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001106525.5 → XP_001106525.1  pleckstrin-2 isoform X1

    See identical proteins and their annotated locations for XP_001106525.1

    UniProtKB/TrEMBL
    A0A1D5RFP4, F7EFD3, G7MYC1
    Related
    ENSMMUP00000059138.2
    Conserved Domains (3) summary
    cd04444
    Location:128 → 236
    DEP_PLEK2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins. Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central ...
    cd13301
    Location:3 → 113
    PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
    cd13302
    Location:242 → 353
    PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2

  2. XM_077941201.1 → XP_077797327.1  pleckstrin-2 isoform X2

RNA

  1. XR_001446305.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials