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TSPAN8 tetraspanin 8 [ Homo sapiens (human) ]

Gene ID: 7103, updated on 1-Aug-2020

Summary

Official Symbol
TSPAN8provided by HGNC
Official Full Name
tetraspanin 8provided by HGNC
Primary source
HGNC:HGNC:11855
See related
Ensembl:ENSG00000127324 MIM:600769
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CO-029; TM4SF3
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 463.8), duodenum (RPKM 388.7) and 5 other tissues See more
Orthologs

Genomic context

See TSPAN8 in Genome Data Viewer
Location:
12q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (71125093..71157999, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (71518877..71551779, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369828 Neighboring gene protein tyrosine phosphatase receptor type B Neighboring gene protein tyrosine phosphatase receptor type R Neighboring gene fumarylacetoacetate hydrolase domain containing 2 pseudogene 1 Neighboring gene uncharacterized LOC105369831 Neighboring gene uncharacterized LOC105369832

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
NHGRI GWA Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetraspanin-8
Names
transmembrane 4 superfamily member 3
tspan-8
tumor-associated antigen CO-029

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046933.1 RefSeqGene

    Range
    5001..37904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001369760.1NP_001356689.1  tetraspanin-8

    Status: REVIEWED

    Source sequence(s)
    AC025575
    Related
    ENSP00000447160.1, ENST00000546561.2
    Conserved Domains (2) summary
    cd03154
    Location:106206
    TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:8230
    Tetraspannin; Tetraspanin family
  2. NM_004616.3NP_004607.1  tetraspanin-8

    See identical proteins and their annotated locations for NP_004607.1

    Status: REVIEWED

    Source sequence(s)
    AC025575
    Consensus CDS
    CCDS8999.1
    UniProtKB/Swiss-Prot
    P19075
    Related
    ENSP00000247829.3, ENST00000247829.8
    Conserved Domains (2) summary
    cd03154
    Location:106206
    TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:8230
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    71125093..71157999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719583.3XP_006719646.1  tetraspanin-8 isoform X1

    See identical proteins and their annotated locations for XP_006719646.1

    UniProtKB/Swiss-Prot
    P19075
    Conserved Domains (2) summary
    cd03154
    Location:106206
    TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:8230
    Tetraspannin; Tetraspanin family
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