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NR2E1 nuclear receptor subfamily 2 group E member 1 [ Homo sapiens (human) ]

Gene ID: 7101, updated on 8-Jul-2021

Summary

Official Symbol
NR2E1provided by HGNC
Official Full Name
nuclear receptor subfamily 2 group E member 1provided by HGNC
Primary source
HGNC:HGNC:7973
See related
Ensembl:ENSG00000112333 MIM:603849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLL; TLX; XTLL
Summary
The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Restricted expression toward brain (RPKM 4.0) See more
Orthologs
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Genomic context

See NR2E1 in Genome Data Viewer
Location:
6q21
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (108166022..108188809)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (108487226..108510013)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene osteoclastogenesis associated transmembrane protein 1 Neighboring gene OSTM1 antisense RNA 1 Neighboring gene sorting nexin 3 Neighboring gene RNA, 5S ribosomal pseudogene 212 Neighboring gene RNA, U6 small nuclear 1144, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in aggressive behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in amygdala development IEA
Inferred from Electronic Annotation
more info
 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anterior commissure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain generation of neurons IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in olfactory bulb development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of timing of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 2 group E member 1
Names
nuclear receptor TLX
protein tailless homolog
tailes-related receptor
tailless

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042807.1 RefSeqGene

    Range
    4965..27748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286102.1NP_001273031.1  nuclear receptor subfamily 2 group E member 1 isoform a

    See identical proteins and their annotated locations for NP_001273031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AF220532, AK131541
    Consensus CDS
    CCDS69165.1
    UniProtKB/Swiss-Prot
    Q9Y466
    Related
    ENSP00000357979.3, ENST00000368983.3
    Conserved Domains (2) summary
    cd06950
    Location:191406
    NR_LBD_Tlx_PNR_like; The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
    cd07163
    Location:45136
    NR_DBD_TLX; DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers
  2. NM_003269.5NP_003260.1  nuclear receptor subfamily 2 group E member 1 isoform b

    See identical proteins and their annotated locations for NP_003260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AF220532, AF411525, AL078596, BC028031
    Consensus CDS
    CCDS5063.1
    UniProtKB/Swiss-Prot
    Q9Y466
    UniProtKB/TrEMBL
    B6ZGT9
    Related
    ENSP00000357982.5, ENST00000368986.9
    Conserved Domains (2) summary
    cd06950
    Location:154369
    NR_LBD_Tlx_PNR_like; The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
    cd07163
    Location:899
    NR_DBD_TLX; DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    108166022..108188809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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