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TLE3 TLE family member 3, transcriptional corepressor [ Homo sapiens (human) ]

Gene ID: 7090, updated on 9-Dec-2018

Summary

Official Symbol
TLE3provided by HGNC
Official Full Name
TLE family member 3, transcriptional corepressorprovided by HGNC
Primary source
HGNC:HGNC:11839
See related
Ensembl:ENSG00000140332 MIM:600190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESG; ESG3; GRG3; HsT18976
Summary
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See TLE3 in Genome Data Viewer
Location:
15q23
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (70047790..70098171, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (70340129..70390274, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 593 Neighboring gene uncharacterized LOC101929129 Neighboring gene uncharacterized LOC105370877 Neighboring gene VISTA enhancer hs359 Neighboring gene microRNA 629 Neighboring gene uncharacterized LOC107984734

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association study of lung function phenotypes in a founder population.
NHGRI GWA Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Pathways from BioSystems

  • Deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
    Deactivation of the beta-catenin transactivating complex, organism-specific biosystemThe mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, S...
  • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
    Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
  • Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
    Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemOnce in the nucleus, beta-catenin is recruited to WNT target genes through interaction with TCF/LEF transcription factors. This family, which consists of TCF7 (also known as TCF1), TCF7L1 (also known...
  • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
    NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
  • Repression of WNT target genes, organism-specific biosystem (from REACTOME)
    Repression of WNT target genes, organism-specific biosystemIn the absence of a WNT signal, many WNT target genes are repressed by Groucho/TLE. Groucho was initially identified in Drosophila, where it has been shown to interact with a variety of proteins to ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
  • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39460, KIAA1547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transducin-like enhancer protein 3
Names
enhancer of split groucho 3
enhancer of split groucho-like protein 3
transducin like enhancer of split 3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 3 short isoform
transducin-like enhancer of split 3, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105192.2NP_001098662.1  transducin-like enhancer protein 3 isoform b

    See identical proteins and their annotated locations for NP_001098662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AK315058, BC043247, BM676381
    Consensus CDS
    CCDS45294.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000394717.2, ENST00000451782.6
    Conserved Domains (4) summary
    cd00200
    Location:481766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:137470
    Atrophin-1; Atrophin-1 family
  2. NM_001282979.1NP_001269908.1  transducin-like enhancer protein 3 isoform e

    See identical proteins and their annotated locations for NP_001269908.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AY583459, BC043247, BM676381, M99438
    Consensus CDS
    CCDS61692.1
    UniProtKB/Swiss-Prot
    Q04726
    UniProtKB/TrEMBL
    Q6PRX3
    Related
    ENSP00000453083.1, ENST00000557997.5
    Conserved Domains (4) summary
    cd00200
    Location:476761
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:481520
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:137466
    Atrophin-1; Atrophin-1 family
  3. NM_001282980.1NP_001269909.1  transducin-like enhancer protein 3 isoform d

    See identical proteins and their annotated locations for NP_001269909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381
    Consensus CDS
    CCDS61691.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000453435.1, ENST00000558379.5
    Conserved Domains (4) summary
    cd00200
    Location:479764
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:484523
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl25496
    Location:251467
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. NM_001282981.1NP_001269910.1  transducin-like enhancer protein 3 isoform f

    See identical proteins and their annotated locations for NP_001269910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. These differences result in a novel 5' coding region and 5' UTR compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC068327, AK298482, BM676381, BP373048
    Consensus CDS
    CCDS61689.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000415057.3, ENST00000440567.7
    Conserved Domains (4) summary
    cd00200
    Location:474759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:479518
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:2126
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:130463
    Atrophin-1; Atrophin-1 family
  5. NM_001282982.1NP_001269911.1  transducin-like enhancer protein 3 isoform g

    See identical proteins and their annotated locations for NP_001269911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents the use of an alternate promoter and has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC068327, AK096779, BM676381
    Consensus CDS
    CCDS73747.1
    UniProtKB/Swiss-Prot
    Q04726
    UniProtKB/TrEMBL
    B3KUA2, F5H7D6
    Related
    ENSP00000442594.1, ENST00000539550.5
    Conserved Domains (3) summary
    cd00200
    Location:411696
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:416455
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:177
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  6. NM_005078.3NP_005069.2  transducin-like enhancer protein 3 isoform a

    See identical proteins and their annotated locations for NP_005069.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381, M99438
    Consensus CDS
    CCDS45293.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000452871.1, ENST00000558939.5
    Conserved Domains (4) summary
    cd00200
    Location:484769
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:489528
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl25496
    Location:251472
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  7. NM_020908.2NP_065959.1  transducin-like enhancer protein 3 isoform c

    See identical proteins and their annotated locations for NP_065959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381
    Consensus CDS
    CCDS58375.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000319233.8, ENST00000317509.12
    Conserved Domains (4) summary
    cd00200
    Location:472757
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:477516
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl25496
    Location:251460
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    70047790..70098171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521983.3XP_011520285.1  transducin-like enhancer protein 3 isoform X12

    Conserved Domains (4) summary
    COG2319
    Location:406691
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:405690
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:410449
    7WD40; WD40 repeat [structural motif]
  2. XM_011521982.3XP_011520284.1  transducin-like enhancer protein 3 isoform X11

    Conserved Domains (4) summary
    COG2319
    Location:411696
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:410695
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:415454
    7WD40; WD40 repeat [structural motif]
  3. XM_006720665.4XP_006720728.1  transducin-like enhancer protein 3 isoform X14

    Conserved Domains (4) summary
    COG2319
    Location:469761
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:475760
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:480519
    7WD40; WD40 repeat [structural motif]
  4. XM_011521980.3XP_011520282.1  transducin-like enhancer protein 3 isoform X7

    Conserved Domains (4) summary
    COG2319
    Location:477769
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:483768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:488527
    7WD40; WD40 repeat [structural motif]
  5. XM_005254633.3XP_005254690.1  transducin-like enhancer protein 3 isoform X15

    See identical proteins and their annotated locations for XP_005254690.1

    Conserved Domains (4) summary
    COG2319
    Location:461753
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:467752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:472511
    7WD40; WD40 repeat [structural motif]
  6. XM_011521977.3XP_011520279.1  transducin-like enhancer protein 3 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:487779
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:493778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:498537
    7WD40; WD40 repeat [structural motif]
  7. XM_005254628.4XP_005254685.1  transducin-like enhancer protein 3 isoform X10

    Conserved Domains (4) summary
    COG2319
    Location:471763
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:477762
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:482521
    7WD40; WD40 repeat [structural motif]
  8. XM_005254625.4XP_005254682.1  transducin-like enhancer protein 3 isoform X8

    Conserved Domains (4) summary
    COG2319
    Location:476768
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:482767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:487526
    7WD40; WD40 repeat [structural motif]
  9. XM_005254623.4XP_005254680.1  transducin-like enhancer protein 3 isoform X5

    Conserved Domains (4) summary
    COG2319
    Location:480772
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:486771
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:491530
    7WD40; WD40 repeat [structural motif]
  10. XM_005254622.5XP_005254679.1  transducin-like enhancer protein 3 isoform X3

    Conserved Domains (4) summary
    COG2319
    Location:485777
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:491776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:496535
    7WD40; WD40 repeat [structural motif]
  11. XM_011521978.3XP_011520280.1  transducin-like enhancer protein 3 isoform X4

    Conserved Domains (4) summary
    cd00200
    Location:489774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:494533
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl25496
    Location:261477
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  12. XM_011521976.3XP_011520278.1  transducin-like enhancer protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011520278.1

    UniProtKB/TrEMBL
    H0YL70
    Related
    ENSP00000453081.1, ENST00000559929.5
    Conserved Domains (4) summary
    cd00200
    Location:494779
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:499538
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl25496
    Location:261482
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  13. XM_011521979.3XP_011520281.1  transducin-like enhancer protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011520281.1

    Related
    ENSP00000453760.1, ENST00000559048.5
    Conserved Domains (4) summary
    COG2319
    Location:423708
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:422707
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:176
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:427466
    7WD40; WD40 repeat [structural motif]
  14. XM_011521981.2XP_011520283.1  transducin-like enhancer protein 3 isoform X9

    Conserved Domains (4) summary
    COG2319
    Location:488747
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:494738
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:499538
    7WD40; WD40 repeat [structural motif]
  15. XM_017022532.2XP_016878021.1  transducin-like enhancer protein 3 isoform X13

    Related
    ENSP00000453373.1, ENST00000561453.5
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