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TLE3 TLE family member 3, transcriptional corepressor [ Homo sapiens (human) ]

Gene ID: 7090, updated on 23-Nov-2021

Summary

Official Symbol
TLE3provided by HGNC
Official Full Name
TLE family member 3, transcriptional corepressorprovided by HGNC
Primary source
HGNC:HGNC:11839
See related
Ensembl:ENSG00000140332 MIM:600190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESG; ESG3; GRG3; HsT18976
Summary
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See TLE3 in Genome Data Viewer
Location:
15q23
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (70047790..70098171, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (70340129..70390256, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 593 Neighboring gene uncharacterized LOC101929129 Neighboring gene uncharacterized LOC105370877 Neighboring gene VISTA enhancer hs359 Neighboring gene microRNA 629 Neighboring gene Sharpr-MPRA regulatory region 6929

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genome-wide association study of lung function phenotypes in a founder population.
GeneReviews: Not available
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39460, KIAA1547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transducin-like enhancer protein 3
Names
enhancer of split groucho 3
enhancer of split groucho-like protein 3
transducin like enhancer of split 3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 3, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105192.3NP_001098662.1  transducin-like enhancer protein 3 isoform b

    See identical proteins and their annotated locations for NP_001098662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AK315058, BC043247, BM676381
    Consensus CDS
    CCDS45294.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000394717.3, ENST00000451782.7
    Conserved Domains (3) summary
    cd00200
    Location:481766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  2. NM_001282979.2NP_001269908.1  transducin-like enhancer protein 3 isoform e

    See identical proteins and their annotated locations for NP_001269908.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AY583459, BC043247, BM676381, M99438
    Consensus CDS
    CCDS61692.1
    UniProtKB/Swiss-Prot
    Q04726
    UniProtKB/TrEMBL
    Q6PRX3
    Related
    ENSP00000453083.1, ENST00000557997.5
    Conserved Domains (3) summary
    cd00200
    Location:476761
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:481520
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. NM_001282980.2NP_001269909.1  transducin-like enhancer protein 3 isoform d

    See identical proteins and their annotated locations for NP_001269909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381
    Consensus CDS
    CCDS61691.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000453435.1, ENST00000558379.5
    Conserved Domains (3) summary
    cd00200
    Location:479764
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:484523
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. NM_001282981.2NP_001269910.1  transducin-like enhancer protein 3 isoform f

    See identical proteins and their annotated locations for NP_001269910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. These differences result in a novel 5' coding region and 5' UTR compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC068327, AK298482, BM676381, BP373048
    Consensus CDS
    CCDS61689.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000415057.3, ENST00000440567.7
    Conserved Domains (3) summary
    cd00200
    Location:474759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:479518
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:2126
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  5. NM_001282982.2NP_001269911.1  transducin-like enhancer protein 3 isoform g

    See identical proteins and their annotated locations for NP_001269911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents the use of an alternate promoter and has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AK096779, BM676381
    Consensus CDS
    CCDS73747.1
    UniProtKB/Swiss-Prot
    Q04726
    UniProtKB/TrEMBL
    B3KUA2, F5H7D6
    Conserved Domains (3) summary
    cd00200
    Location:411696
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:416455
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:177
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  6. NM_005078.4NP_005069.2  transducin-like enhancer protein 3 isoform a

    See identical proteins and their annotated locations for NP_005069.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381, M99438
    Consensus CDS
    CCDS45293.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000452871.1, ENST00000558939.5
    Conserved Domains (3) summary
    cd00200
    Location:484769
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:489528
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  7. NM_020908.3NP_065959.1  transducin-like enhancer protein 3 isoform c

    See identical proteins and their annotated locations for NP_065959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381
    Consensus CDS
    CCDS58375.1
    UniProtKB/Swiss-Prot
    Q04726
    Related
    ENSP00000319233.8, ENST00000317509.12
    Conserved Domains (4) summary
    cd00200
    Location:472757
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:251460
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:477516
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    70047790..70098171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521983.3XP_011520285.1  transducin-like enhancer protein 3 isoform X12

    Conserved Domains (4) summary
    COG2319
    Location:406691
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:405690
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:410449
    7WD40; WD40 repeat [structural motif]
  2. XM_011521982.3XP_011520284.1  transducin-like enhancer protein 3 isoform X11

    Conserved Domains (4) summary
    COG2319
    Location:411696
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:410695
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:415454
    7WD40; WD40 repeat [structural motif]
  3. XM_006720665.4XP_006720728.1  transducin-like enhancer protein 3 isoform X14

    Conserved Domains (3) summary
    cd00200
    Location:475760
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:480519
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. XM_011521980.3XP_011520282.1  transducin-like enhancer protein 3 isoform X7

    Conserved Domains (3) summary
    cd00200
    Location:483768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:488527
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  5. XM_005254633.3XP_005254690.1  transducin-like enhancer protein 3 isoform X15

    See identical proteins and their annotated locations for XP_005254690.1

    Conserved Domains (3) summary
    cd00200
    Location:467752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:472511
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  6. XM_011521977.3XP_011520279.1  transducin-like enhancer protein 3 isoform X2

    Conserved Domains (3) summary
    cd00200
    Location:493778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:498537
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  7. XM_005254628.4XP_005254685.1  transducin-like enhancer protein 3 isoform X10

    Conserved Domains (3) summary
    cd00200
    Location:477762
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:482521
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  8. XM_005254625.4XP_005254682.1  transducin-like enhancer protein 3 isoform X8

    Conserved Domains (4) summary
    cd00200
    Location:482767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:261470
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:487526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  9. XM_005254623.4XP_005254680.1  transducin-like enhancer protein 3 isoform X5

    Conserved Domains (3) summary
    cd00200
    Location:486771
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:491530
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  10. XM_005254622.5XP_005254679.1  transducin-like enhancer protein 3 isoform X3

    Conserved Domains (3) summary
    cd00200
    Location:491776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  11. XM_011521978.3XP_011520280.1  transducin-like enhancer protein 3 isoform X4

    Conserved Domains (3) summary
    cd00200
    Location:489774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:494533
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  12. XM_011521976.3XP_011520278.1  transducin-like enhancer protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011520278.1

    UniProtKB/TrEMBL
    H0YL70
    Related
    ENSP00000453081.1, ENST00000559929.5
    Conserved Domains (3) summary
    cd00200
    Location:494779
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:499538
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  13. XM_011521979.3XP_011520281.1  transducin-like enhancer protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011520281.1

    Related
    ENSP00000453760.1, ENST00000559048.5
    Conserved Domains (3) summary
    cd00200
    Location:422707
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:427466
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:176
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  14. XM_011521981.2XP_011520283.1  transducin-like enhancer protein 3 isoform X9

    Conserved Domains (4) summary
    COG2319
    Location:488747
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:494738
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:499538
    7WD40; WD40 repeat [structural motif]
  15. XM_017022532.2XP_016878021.1  transducin-like enhancer protein 3 isoform X13

    Related
    ENSP00000453373.1, ENST00000561453.5
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