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Glb1l3 galactosidase, beta 1 like 3 [ Mus musculus (house mouse) ]

Gene ID: 70893, updated on 27-Nov-2024

Summary

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Official Symbol
Glb1l3provided by MGI
Official Full Name
galactosidase, beta 1 like 3provided by MGI
Primary source
MGI:MGI:1918143
See related
Ensembl:ENSMUSG00000031966 AllianceGenome:MGI:1918143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921509F24Rik
Summary
Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be active in vacuole. Orthologous to human GLB1L3 (galactosidase beta 1 like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 18.9) and testis adult (RPKM 12.3) See more
Orthologs
human all
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Genomic context

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See Glb1l3 in Genome Data Viewer
Location:
9 A4; 9 11.67 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26729249..26773394, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26817953..26862099, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene beta-1,3-glucuronyltransferase 1 Neighboring gene galactosidase, beta 1-like 2 Neighboring gene STARR-seq mESC enhancer starr_23614 Neighboring gene predicted gene 1110 Neighboring gene STARR-seq mESC enhancer starr_23615 Neighboring gene STARR-seq mESC enhancer starr_23616 Neighboring gene zinc finger CCCH type containing 11A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered expression of β-galactosidase-1-like protein 3 (Glb1l3) in the retinal pigment epithelium (RPE)-specific 65-kDa protein knock-out mouse model of Leber's congenital amaurosis. Le Carré J, et al. Mol Vis, 2011. PMID 21633714, Free PMC Article
  2. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early-onset downregulation of Glb1l3 in Rpe65-related disease. Impaired expression of Glb1l3 is mostly due to absence of chromophore 11-cis retinal.
    Title: Altered expression of β-galactosidase-1-like protein 3 (Glb1l3) in the retinal pigment epithelium (RPE)-specific 65-kDa protein knock-out mouse model of Leber's congenital amaurosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactosidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-galactosidase-1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113323.1 → NP_001106794.1  beta-galactosidase-1-like protein 3 precursor

    See identical proteins and their annotated locations for NP_001106794.1

    Status: VALIDATED

    Source sequence(s)
    AC109831, BB281918, BC132200, BY363615, DV051729
    Consensus CDS
    CCDS85650.1
    UniProtKB/Swiss-Prot
    A2RSQ1, Q9D5X3
    UniProtKB/TrEMBL
    A0A1B0GSK9
    Related
    ENSMUSP00000147979.2, ENSMUST00000210274.2
    Conserved Domains (1) summary
    pfam01301
    Location:69 → 379
    Glyco_hydro_35; Glycosyl hydrolases family 35

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    26729249..26773394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510593.5 → XP_006510656.1  beta-galactosidase-1-like protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006510656.1

    UniProtKB/Swiss-Prot
    A2RSQ1, Q9D5X3
    UniProtKB/TrEMBL
    A0A1B0GSK9
    Conserved Domains (1) summary
    pfam01301
    Location:69 → 379
    Glyco_hydro_35; Glycosyl hydrolases family 35

  2. XM_006510595.3 → XP_006510658.1  beta-galactosidase-1-like protein 3 isoform X5

    Conserved Domains (2) summary
    PRK10531
    Location:255 → 286
    PRK10531; putative acyl-CoA thioester hydrolase
    cl38930
    Location:1 → 53
    AmyAc_family; Alpha amylase catalytic domain family

  3. XM_006510591.5 → XP_006510654.1  beta-galactosidase-1-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A2RSQ1, Q9D5X3
    Conserved Domains (1) summary
    pfam01301
    Location:69 → 379
    Glyco_hydro_35; Glycosyl hydrolases family 35

  4. XM_017313588.3 → XP_017169077.1  beta-galactosidase-1-like protein 3 isoform X3

    Conserved Domains (2) summary
    PRK10531
    Location:316 → 347
    PRK10531; putative acyl-CoA thioester hydrolase
    cl38930
    Location:17 → 113
    AmyAc_family; Alpha amylase catalytic domain family

  5. XM_006510594.5 → XP_006510657.1  beta-galactosidase-1-like protein 3 isoform X4

    Conserved Domains (2) summary
    PRK10531
    Location:256 → 287
    PRK10531; putative acyl-CoA thioester hydrolase
    cl38930
    Location:1 → 53
    AmyAc_family; Alpha amylase catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RSQ1.1 GenPept UniProtKB/Swiss-Prot:A2RSQ1

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