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Ttll7 tubulin tyrosine ligase-like family, member 7 [ Mus musculus (house mouse) ]

Gene ID: 70892, updated on 7-Feb-2023

Summary

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Official Symbol
Ttll7provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 7provided by MGI
Primary source
MGI:MGI:1918142
See related
Ensembl:ENSMUSG00000036745 AllianceGenome:MGI:1918142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mTTLL7; C630030B20; 1110049N09Rik; 4921517B04Rik
Summary
Enables tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation. Located in 9+0 non-motile cilium and ciliary basal body. Orthologous to human TTLL7 (tubulin tyrosine ligase like 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 11.7), cortex adult (RPKM 10.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Ttll7 in Genome Data Viewer
Location:
3; 3 H2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146557312..146690156)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146852184..146984009)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein kinase, cAMP dependent, catalytic, beta Neighboring gene predicted gene, 51406 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 1 pseudogene Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 29771 Neighboring gene predicted gene, 36726 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1528.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway. Mukai M, et al. Biochemistry, 2009 Feb 10. PMID 19152315
  2. Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Garnham CP, et al. Cell, 2015 May 21. PMID 25959773, Free PMC Article
  3. Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. Bodakuntla S, et al. EMBO J, 2021 Sep 1. PMID 34309047, Free PMC Article
  4. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites. Ikegami K, et al. J Biol Chem, 2006 Oct 13. PMID 16901895, Free PMC Article
  5. Megabase deletions of gene deserts result in viable mice. Nóbrega MA, et al. Nature, 2004 Oct 21. PMID 15496924

See all (24) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct roles of alpha- and beta-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration.
    Title: Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration.
  2. TTLL7, the most abundant neuronal glutamylase, adds glutamates preferentially to the beta-tubulin tail; coupled with ensemble and single-molecule biochemistry, the hybrid X-ray and cryo-electron microscopy structure of TTLL7 bound to the microtubule delineates a tripartite microtubule recognition strategy.
    Title: Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.
  3. TTLL7 performs both the initiation and elongation of polyglutamylation on beta-tubulin; the mechanism of binding of three substrates glutamate, ATP, and tubulin to the enzyme is a random sequential pathway.
    Title: Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway.
  4. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites
    Title: TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin-glutamic acid ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tubulin-glutamic acid ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein polyglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein polyglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyglutamylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in 9+0 non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin polyglutamylase TTLL7
Names
polyglutamylase
tubulin--tyrosine ligase-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302957.2 → NP_001289886.1  tubulin polyglutamylase TTLL7 isoform Ttll7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (Ttll7).
    Source sequence(s)
    AC165225, AM690751, BP758417, CJ110550
    Consensus CDS
    CCDS51094.2
    UniProtKB/TrEMBL
    A0A0G2LB90
    Related
    ENSMUSP00000043753.8, ENSMUST00000037942.11
    Conserved Domains (1) summary
    pfam03133
    Location:91 → 376
    TTL; Tubulin-tyrosine ligase family

  2. NM_001302958.1 → NP_001289887.1  tubulin polyglutamylase TTLL7 isoform Ttll7s

    See identical proteins and their annotated locations for NP_001289887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons but includes an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (Ttll7s) has a distinct C-terminus and is shorter than isoform Ttll7.
    Source sequence(s)
    AK014905, AM690750, CJ110550
    UniProtKB/Swiss-Prot
    A4Q9F0
    Related
    ENSMUST00000038090.12
    Conserved Domains (1) summary
    pfam03133
    Location:91 → 376
    TTL; Tubulin-tyrosine ligase family

  3. NM_001357217.1 → NP_001344146.1  tubulin polyglutamylase TTLL7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115889, AC165225, BM899995
    Consensus CDS
    CCDS89701.1
    UniProtKB/TrEMBL
    E9Q6C6
    Related
    ENSMUSP00000101740.2, ENSMUST00000106134.4
    Conserved Domains (1) summary
    pfam03133
    Location:91 → 376
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146557312..146690156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163314.1 → XP_036019207.1  tubulin polyglutamylase TTLL7 isoform X3

    Conserved Domains (1) summary
    pfam03133
    Location:91 → 376
    TTL; Tubulin-tyrosine ligase family

  2. XM_036163315.1 → XP_036019208.1  tubulin polyglutamylase TTLL7 isoform X4

    Conserved Domains (1) summary
    pfam03133
    Location:91 → 376
    TTL; Tubulin-tyrosine ligase family

  3. XM_036163312.1 → XP_036019205.1  tubulin polyglutamylase TTLL7 isoform X1

    Conserved Domains (1) summary
    pfam03133
    Location:91 → 376
    TTL; Tubulin-tyrosine ligase family

  4. XM_036163313.1 → XP_036019206.1  tubulin polyglutamylase TTLL7 isoform X2

    Conserved Domains (1) summary
    pfam03133
    Location:91 → 376
    TTL; Tubulin-tyrosine ligase family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027594.1: Suppressed sequence

    Description
    NM_027594.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4Q9F0.1 GenPept UniProtKB/Swiss-Prot:A4Q9F0

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