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Ints10 integrator complex subunit 10 [ Mus musculus (house mouse) ]

Gene ID: 70885, updated on 4-Dec-2022

Summary

Official Symbol
Ints10provided by MGI
Official Full Name
integrator complex subunit 10provided by MGI
Primary source
MGI:MGI:1918135
See related
Ensembl:ENSMUSG00000031864 AllianceGenome:MGI:1918135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921521J11Rik
Summary
Predicted to be involved in snRNA processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and spinal cord. Orthologous to human INTS10 (integrator complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.4), testis adult (RPKM 15.1) and 26 other tissues See more
Orthologs
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Genomic context

See Ints10 in Genome Data Viewer
Location:
8; 8 B3.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69245729..69282062)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (68793929..68829410)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 4A Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene predicted gene, 51577 Neighboring gene lipoprotein lipase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrator complex subunit 10
Names
int10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293791.1NP_001280720.1  integrator complex subunit 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC123813, AK040574, AK147743
    Consensus CDS
    CCDS80885.1
    UniProtKB/Swiss-Prot
    Q8K2A7
    UniProtKB/TrEMBL
    E9Q360
    Related
    ENSMUSP00000105871.2, ENSMUST00000110242.8
  2. NM_001293792.1NP_001280721.1  integrator complex subunit 10 isoform 2

    See identical proteins and their annotated locations for NP_001280721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same length but differs in an internal segment compared to isoform 1.
    Source sequence(s)
    AC123813, AK034498, AK040574
    Consensus CDS
    CCDS80886.1
    UniProtKB/Swiss-Prot
    Q8K2A7
    UniProtKB/TrEMBL
    A0A0R4J0V1
    Related
    ENSMUSP00000069908.2, ENSMUST00000070713.8
  3. NM_001359129.1NP_001346058.1  integrator complex subunit 10 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is longer compared to isoform 1.
    Source sequence(s)
    AC123813
  4. NM_027590.4NP_081866.1  integrator complex subunit 10 isoform 3

    See identical proteins and their annotated locations for NP_081866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC123813, AK014939, AK040574
    Consensus CDS
    CCDS22342.1
    UniProtKB/Swiss-Prot
    Q8K2A7, Q9D5U1
    Related
    ENSMUSP00000034328.7, ENSMUST00000034328.13

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    69245729..69282062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509741.4XP_006509804.1  integrator complex subunit 10 isoform X1

  2. XM_006509743.5XP_006509806.1  integrator complex subunit 10 isoform X2

  3. XM_006509747.5XP_006509810.1  integrator complex subunit 10 isoform X5

  4. XM_036154289.1XP_036010182.1  integrator complex subunit 10 isoform X4

  5. XM_006509744.5XP_006509807.1  integrator complex subunit 10 isoform X3

  6. XM_036154290.1XP_036010183.1  integrator complex subunit 10 isoform X6

    Related
    ENSMUSP00000105870.2, ENSMUST00000110241.8
  7. XM_011242326.3XP_011240628.1  integrator complex subunit 10 isoform X7

  8. XM_030243763.2XP_030099623.1  integrator complex subunit 10 isoform X9

  9. XM_030243764.2XP_030099624.1  integrator complex subunit 10 isoform X10

  10. XM_030243765.1XP_030099625.1  integrator complex subunit 10 isoform X11

  11. XM_036154291.1XP_036010184.1  integrator complex subunit 10 isoform X8

RNA

  1. XR_004934877.1 RNA Sequence

  2. XR_004934876.1 RNA Sequence