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Nt5c1b 5'-nucleotidase, cytosolic IB [ Mus musculus (house mouse) ]

Gene ID: 70881, updated on 26-Sep-2022

Summary

Official Symbol
Nt5c1bprovided by MGI
Official Full Name
5'-nucleotidase, cytosolic IBprovided by MGI
Primary source
MGI:MGI:1918131
See related
Ensembl:ENSMUSG00000020622 AllianceGenome:MGI:1918131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIRP; cN1B; CN-IB; 4921514H13Rik
Summary
Enables 5'-nucleotidase activity. Involved in AMP catabolic process and allantoin metabolic process. Acts upstream of or within nucleoside metabolic process. Is active in cytosol. Is expressed in several structures, including genitourinary system; gut; and skin. Orthologous to several human genes including NT5C1B-RDH14 (NT5C1B-RDH14 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 189.3) See more
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Genomic context

See Nt5c1b in Genome Data Viewer
Location:
12; 12 A1.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (10419971..10440174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (10369971..10390174)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46324 Neighboring gene acetyl-Coenzyme A carboxylase alpha pseudogene Neighboring gene retinol dehydrogenase 14 (all-trans and 9-cis) Neighboring gene predicted gene, 38407

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
 
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in AMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleoside metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytosolic 5'-nucleotidase 1B
Names
5'nucleotidase
autoimmune infertility-related protein
cytosolic 5'-nucleotidase IB
NP_001297511.1
NP_001360900.1
NP_001360901.1
NP_001360902.1
NP_001360903.1
NP_001360904.1
NP_081864.2
XP_006515274.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310582.1NP_001297511.1  cytosolic 5'-nucleotidase 1B isoform 2

    See identical proteins and their annotated locations for NP_001297511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC157570, BC060976
    Consensus CDS
    CCDS79106.1
    UniProtKB/TrEMBL
    Q6P906
    Related
    ENSMUSP00000112694.2, ENSMUST00000118657.8
    Conserved Domains (1) summary
    pfam06189
    Location:280548
    5-nucleotidase; 5'-nucleotidase
  2. NM_001373971.1NP_001360900.1  cytosolic 5'-nucleotidase 1B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88310.1
    UniProtKB/TrEMBL
    A0A1W2P6X8
    Related
    ENSMUSP00000151401.2, ENSMUST00000219826.2
    Conserved Domains (1) summary
    pfam06189
    Location:356624
    5-nucleotidase; 5'-nucleotidase
  3. NM_001373972.1NP_001360901.1  cytosolic 5'-nucleotidase 1B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Conserved Domains (1) summary
    pfam06189
    Location:354622
    5-nucleotidase; 5'-nucleotidase
  4. NM_001373973.1NP_001360902.1  cytosolic 5'-nucleotidase 1B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88309.1
    UniProtKB/TrEMBL
    A0A1W2P7K9
    Related
    ENSMUSP00000151734.2, ENSMUST00000217944.2
    Conserved Domains (1) summary
    pfam06189
    Location:340608
    5-nucleotidase; 5'-nucleotidase
  5. NM_001373974.1NP_001360903.1  cytosolic 5'-nucleotidase 1B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88311.1
    UniProtKB/TrEMBL
    A0A1W2P7E9
    Related
    ENSMUSP00000151618.3, ENSMUST00000218339.3
    Conserved Domains (1) summary
    pfam06189
    Location:296564
    5-nucleotidase; 5'-nucleotidase
  6. NM_001373975.1NP_001360904.1  cytosolic 5'-nucleotidase 1B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88312.1
    UniProtKB/TrEMBL
    A0A1Y7VK90
    Related
    ENSMUSP00000152838.2, ENSMUST00000223534.2
    Conserved Domains (1) summary
    pfam06189
    Location:282550
    5-nucleotidase; 5'-nucleotidase
  7. NM_027588.3NP_081864.2  cytosolic 5'-nucleotidase 1B isoform 1

    See identical proteins and their annotated locations for NP_081864.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK014892, BB573272
    Consensus CDS
    CCDS25810.1
    UniProtKB/Swiss-Prot
    Q91Y48, Q91YE9
    Related
    ENSMUSP00000002456.9, ENSMUST00000002456.10
    Conserved Domains (1) summary
    pfam06189
    Location:298566
    5-nucleotidase; 5'-nucleotidase

RNA

  1. NR_164200.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000219292.2
  2. NR_164201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000219049.2
  3. NR_164202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218417.2
  4. NR_164203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218287.2
  5. NR_164204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218551.2
  6. NR_164205.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218026.2
  7. NR_164206.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
  8. NR_164207.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218327.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    10419971..10440174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515211.4XP_006515274.1  cytosolic 5'-nucleotidase 1B isoform X1

    Related
    ENSMUSP00000151627.2, ENSMUST00000220257.2
    Conserved Domains (1) summary
    pfam06189
    Location:356376
    5-nucleotidase; 5'-nucleotidase