Format

Send to:

Choose Destination

TLE1 transducin like enhancer of split 1 [ Homo sapiens (human) ]

Gene ID: 7088, updated on 2-Oct-2018

Summary

Official Symbol
TLE1provided by HGNC
Official Full Name
transducin like enhancer of split 1provided by HGNC
Primary source
HGNC:HGNC:11837
See related
Ensembl:ENSG00000196781 MIM:600189; Vega:OTTHUMG00000021008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESG; ESG1; GRG1
Expression
Ubiquitous expression in fat (RPKM 15.1), endometrium (RPKM 10.2) and 25 other tissues See more
Orthologs

Genomic context

See TLE1 in Genome Data Viewer
Location:
9q21.32
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (81583683..81689535, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (84198598..84303596, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CST complex subunit TEN1-like Neighboring gene VISTA enhancer hs1118 Neighboring gene uncharacterized LOC105376106 Neighboring gene VISTA enhancer hs1359 Neighboring gene VISTA enhancer hs556 Neighboring gene uncharacterized LOC101927502 Neighboring gene RNA, U6 small nuclear 1035, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 287

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Multiple loci influencing hippocampal degeneration identified by genome scan.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of transducin-like enhancer of split 1 homolog protein (TLE1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transducin-like enhancer protein 1
Names
enhancer of split groucho-like protein 1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303103.1NP_001290032.1  transducin-like enhancer protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001290032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209854, AL353682, BC000228, BC010100, DB211613
    UniProtKB/Swiss-Prot
    Q04724
    UniProtKB/TrEMBL
    Q59EF7
    Conserved Domains (4) summary
    cd00200
    Location:493777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:497536
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:329486
    Atrophin-1; Atrophin-1 family
  2. NM_001303104.1NP_001290033.1  transducin-like enhancer protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001290033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB209854, AK293606, AL353682, BC010100, DB211613
    UniProtKB/Swiss-Prot
    Q04724
    UniProtKB/TrEMBL
    B4DEF9, Q59EF7
    Conserved Domains (3) summary
    cd00200
    Location:468752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:472511
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. NM_005077.4NP_005068.2  transducin-like enhancer protein 1 isoform 2

    See identical proteins and their annotated locations for NP_005068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB209854, BC010100, DB211613
    Consensus CDS
    CCDS6661.1
    UniProtKB/Swiss-Prot
    Q04724
    UniProtKB/TrEMBL
    Q59EF7
    Related
    ENSP00000365682.3, OTTHUMP00000022733, ENST00000376499.7, OTTHUMT00000055407
    Conserved Domains (4) summary
    cd00200
    Location:483767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:487526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:319476
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    81583683..81689535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252162.1XP_005252219.1  transducin-like enhancer protein 1 isoform X13

    Conserved Domains (4) summary
    COG2319
    Location:436728
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:443727
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:447486
    7WD40; WD40 repeat [structural motif]
  2. XM_006717263.1XP_006717326.1  transducin-like enhancer protein 1 isoform X17

    See identical proteins and their annotated locations for XP_006717326.1

    Conserved Domains (3) summary
    cd00200
    Location:481765
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:485524
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. XM_005252154.1XP_005252211.1  transducin-like enhancer protein 1 isoform X5

    Conserved Domains (4) summary
    COG2319
    Location:509801
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:516800
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:520559
    7WD40; WD40 repeat [structural motif]
  4. XM_006717262.1XP_006717325.1  transducin-like enhancer protein 1 isoform X9

    See identical proteins and their annotated locations for XP_006717325.1

    Conserved Domains (3) summary
    cd00200
    Location:482766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  5. XM_005252153.1XP_005252210.1  transducin-like enhancer protein 1 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:510802
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:517801
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:521560
    7WD40; WD40 repeat [structural motif]
  6. XM_006717260.1XP_006717323.1  transducin-like enhancer protein 1 isoform X12

    Conserved Domains (4) summary
    COG2319
    Location:446738
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:453737
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:457496
    7WD40; WD40 repeat [structural motif]
  7. XM_017015065.1XP_016870554.1  transducin-like enhancer protein 1 isoform X8

  8. XM_006717258.1XP_006717321.1  transducin-like enhancer protein 1 isoform X3

    Conserved Domains (4) summary
    COG2319
    Location:519811
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:526810
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:530569
    7WD40; WD40 repeat [structural motif]
  9. XM_005252156.3XP_005252213.1  transducin-like enhancer protein 1 isoform X6

    See identical proteins and their annotated locations for XP_005252213.1

    Conserved Domains (3) summary
    cd00200
    Location:492776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  10. XM_005252152.1XP_005252209.1  transducin-like enhancer protein 1 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:519811
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:526810
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:530569
    7WD40; WD40 repeat [structural motif]
  11. XM_005252151.1XP_005252208.1  transducin-like enhancer protein 1 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:520812
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:527811
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:531570
    7WD40; WD40 repeat [structural motif]
  12. XM_006717259.4XP_006717322.1  transducin-like enhancer protein 1 isoform X11

    Conserved Domains (4) summary
    COG2319
    Location:464756
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:471755
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:177
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:475514
    7WD40; WD40 repeat [structural motif]
  13. XM_006717261.2XP_006717324.1  transducin-like enhancer protein 1 isoform X15

    Conserved Domains (3) summary
    COG2319
    Location:411697
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:416455
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:412696
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  14. XM_005252163.2XP_005252220.1  transducin-like enhancer protein 1 isoform X16

    See identical proteins and their annotated locations for XP_005252220.1

    Conserved Domains (4) summary
    cd00200
    Location:409693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:413452
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:245402
    Atrophin-1; Atrophin-1 family
  15. XM_011518951.2XP_011517253.1  transducin-like enhancer protein 1 isoform X10

    See identical proteins and their annotated locations for XP_011517253.1

    Conserved Domains (4) summary
    cd00200
    Location:482766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:318475
    Atrophin-1; Atrophin-1 family
  16. XM_017015064.1XP_016870553.1  transducin-like enhancer protein 1 isoform X7

    Conserved Domains (4) summary
    COG2319
    Location:485777
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:492776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:496535
    7WD40; WD40 repeat [structural motif]
  17. XM_017015066.1XP_016870555.1  transducin-like enhancer protein 1 isoform X14

    Conserved Domains (4) summary
    cd00200
    Location:437721
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:441480
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:177
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:273430
    Atrophin-1; Atrophin-1 family
Support Center