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ICAM5 intercellular adhesion molecule 5 [ Homo sapiens (human) ]

Gene ID: 7087, updated on 1-Jun-2020

Summary

Official Symbol
ICAM5provided by HGNC
Official Full Name
intercellular adhesion molecule 5provided by HGNC
Primary source
HGNC:HGNC:5348
See related
Ensembl:ENSG00000105376 MIM:601852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLN; TLCN
Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 11.7), lung (RPKM 3.3) and 1 other tissue See more
Orthologs

Genomic context

See ICAM5 in Genome Data Viewer
Location:
19p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10289351..10296778)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10400655..10407454)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372272 Neighboring gene intercellular adhesion molecule 1 Neighboring gene intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Neighboring gene CRISPRi-validated cis-regulatory element chr19.1775 Neighboring gene zinc finger GATA like protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
intercellular adhesion molecule 5
Names
ICAM-5
intercellular adhesion molecule 5, telencephalin
telencephalin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003259.4NP_003250.3  intercellular adhesion molecule 5 precursor

    See identical proteins and their annotated locations for NP_003250.3

    Status: REVIEWED

    Source sequence(s)
    AC011511, AI199660, AI568610, BC030132, U72671
    Consensus CDS
    CCDS12233.1
    UniProtKB/Swiss-Prot
    Q9UMF0
    UniProtKB/TrEMBL
    Q8N6I2
    Related
    ENSP00000221980.3, ENST00000221980.5
    Conserved Domains (6) summary
    cd05755
    Location:120219
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00408
    Location:761821
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:759831
    IG_like; Immunoglobulin like
    pfam03921
    Location:31103
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    pfam13895
    Location:325404
    Ig_2; Immunoglobulin domain
    cl11960
    Location:512570
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10289351..10296778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528229.1XP_011526531.1  intercellular adhesion molecule 5 isoform X1

    See identical proteins and their annotated locations for XP_011526531.1

    UniProtKB/Swiss-Prot
    Q9UMF0
    Conserved Domains (6) summary
    cd05755
    Location:120219
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00408
    Location:761821
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:759831
    IG_like; Immunoglobulin like
    pfam03921
    Location:31103
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    pfam13895
    Location:325404
    Ig_2; Immunoglobulin domain
    cl11960
    Location:512570
    Ig; Immunoglobulin domain
  2. XM_017027185.1XP_016882674.1  intercellular adhesion molecule 5 isoform X2

RNA

  1. XR_001753749.2 RNA Sequence

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