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Prss22 serine protease 22 [ Mus musculus (house mouse) ]

Gene ID: 70835, updated on 12-May-2024

Summary

Official Symbol
Prss22provided by MGI
Official Full Name
serine protease 22provided by MGI
Primary source
MGI:MGI:1918085
See related
Ensembl:ENSMUSG00000045027 AllianceGenome:MGI:1918085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BSSP-4; SP001LA; 4733401N09Rik
Summary
Predicted to enable peptidase activator activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of peptidase activity and proteolysis. Predicted to be located in extracellular space. Is expressed in brain; eye; lung; reproductive system; and stomach. Orthologous to human PRSS22 (serine protease 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 6.1), stomach adult (RPKM 0.6) and 4 other tissues See more
Orthologs
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Genomic context

See Prss22 in Genome Data Viewer
Location:
17 A3.3; 17 12.18 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24212508..24219696, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23993534..24000722, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene spermine binding protein-like Neighboring gene predicted gene, 41546 Neighboring gene serine protease 30 Neighboring gene predicted gene, 41547 Neighboring gene STARR-seq mESC enhancer starr_42070 Neighboring gene predicted gene, 25092

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of peptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
brain-specific serine protease 4
Names
protease, serine 22
serine protease 26
tryptase epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133731.2NP_598492.2  brain-specific serine protease 4 precursor

    See identical proteins and their annotated locations for NP_598492.2

    Status: VALIDATED

    Source sequence(s)
    AB010778, AK014645, CD773447
    Consensus CDS
    CCDS37482.1
    UniProtKB/Swiss-Prot
    Q7TML0, Q9ER10
    Related
    ENSMUSP00000039808.7, ENSMUST00000041649.8
    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24212508..24219696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524905.4XP_006524968.4  brain-specific serine protease 4 isoform X1

    Conserved Domains (1) summary
    cd00190
    Location:108346
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006524906.2XP_006524969.1  brain-specific serine protease 4 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:4232
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...