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TK1 thymidine kinase 1 [ Homo sapiens (human) ]

Gene ID: 7083, updated on 16-Jan-2019

Summary

Official Symbol
TK1provided by HGNC
Official Full Name
thymidine kinase 1provided by HGNC
Primary source
HGNC:HGNC:11830
See related
Ensembl:ENSG00000167900 MIM:188300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TK2
Summary
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
Expression
Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 12.6) and 18 other tissues See more
Orthologs

Genomic context

See TK1 in Genome Data Viewer
Location:
17q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (78174079..78187204, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76170160..76183285, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 99 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2 Neighboring gene uncharacterized LOC107985050 Neighboring gene synaptogyrin 2 Neighboring gene arylformamidase Neighboring gene baculoviral IAP repeat containing 5 Neighboring gene transmembrane protein 235

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates TK1 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleoside kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thymidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxyribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
pyrimidine nucleoside salvage TAS
Traceable Author Statement
more info
 
thymidine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thymidine kinase, cytosolic
Names
cytosolic thymidine kinase
epididymis secretory sperm binding protein
thymidine kinase 1 soluble isoform
NP_001333592.1
NP_003249.3
XP_016880481.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051962.1 RefSeqGene

    Range
    5001..18126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346663.1NP_001333592.1  thymidine kinase, cytosolic isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC021593, AC087645
    Consensus CDS
    CCDS86643.1
    UniProtKB/TrEMBL
    K7ES52
    Related
    ENSP00000468556.1, ENST00000590862.5
    Conserved Domains (1) summary
    cl23762
    Location:18174
    TK; Thymidine kinase
  2. NM_001363848.1NP_001350777.1  thymidine kinase, cytosolic isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC021593, AC087645
    Consensus CDS
    CCDS86642.1
    Conserved Domains (1) summary
    cl23762
    Location:18225
    TK; Thymidine kinase
  3. NM_003258.5NP_003249.3  thymidine kinase, cytosolic isoform 1

    See identical proteins and their annotated locations for NP_003249.3

    Status: REVIEWED

    Source sequence(s)
    BC006484, BI754079
    Consensus CDS
    CCDS11754.1
    UniProtKB/Swiss-Prot
    P04183
    Related
    ENSP00000301634.6, ENST00000301634.11
    Conserved Domains (1) summary
    cl23762
    Location:18192
    TK; Thymidine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    78174079..78187204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024992.2XP_016880481.2  thymidine kinase, cytosolic isoform X1

    Related
    ENSP00000468425.1, ENST00000588734.5
    Conserved Domains (1) summary
    cl23762
    Location:18225
    TK; Thymidine kinase
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