U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TK1 thymidine kinase 1 [ Homo sapiens (human) ]

Gene ID: 7083, updated on 18-Sep-2024

Summary

Official Symbol
TK1provided by HGNC
Official Full Name
thymidine kinase 1provided by HGNC
Primary source
HGNC:HGNC:11830
See related
Ensembl:ENSG00000167900 MIM:188300; AllianceGenome:HGNC:11830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TK2
Summary
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
Expression
Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 12.6) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TK1 in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78174079..78187204, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79068173..79081298, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76170160..76183285, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 99 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76154005-76154506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9049 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76160142-76160642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12875 Neighboring gene synaptogyrin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76171843-76172621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76172622-76173399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76180346-76181247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9052 Neighboring gene arylformamidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12879 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:76207979-76208182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76210079-76210980 Neighboring gene baculoviral IAP repeat containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates TK1 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thymidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thymidine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thymidine kinase, cytosolic
Names
cytosolic thymidine kinase
epididymis secretory sperm binding protein
NP_001333592.1
NP_001350777.1
NP_003249.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051962.1 RefSeqGene

    Range
    5153..18114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346663.2NP_001333592.1  thymidine kinase, cytosolic isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC021593, AC087645
    Consensus CDS
    CCDS86643.1
    UniProtKB/TrEMBL
    K7ERJ1, K7ES52
    Related
    ENSP00000468556.1, ENST00000590862.5
    Conserved Domains (1) summary
    cl23762
    Location:18174
    TK; Thymidine kinase
  2. NM_001363848.1NP_001350777.1  thymidine kinase, cytosolic isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC021593, AC087645
    Consensus CDS
    CCDS86642.1
    UniProtKB/TrEMBL
    B5BU32, B5BUF9, K7ERV3
    Related
    ENSP00000468425.1, ENST00000588734.5
    Conserved Domains (1) summary
    cl23762
    Location:18225
    TK; Thymidine kinase
  3. NM_003258.5NP_003249.3  thymidine kinase, cytosolic isoform 1

    See identical proteins and their annotated locations for NP_003249.3

    Status: REVIEWED

    Source sequence(s)
    BC006484, BI754079
    Consensus CDS
    CCDS11754.1
    UniProtKB/Swiss-Prot
    B2RC58, P04183, Q969V0, Q9UMG9
    UniProtKB/TrEMBL
    A0A384MDV9, B5BU32, B5BUF9
    Related
    ENSP00000301634.6, ENST00000301634.12
    Conserved Domains (1) summary
    cl23762
    Location:18192
    TK; Thymidine kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    78174079..78187204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79068173..79081298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)