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Hmgxb4 HMG box domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 70823, updated on 21-Dec-2022

Summary

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Official Symbol
Hmgxb4provided by MGI
Official Full Name
HMG box domain containing 4provided by MGI
Primary source
MGI:MGI:1918073
See related
Ensembl:ENSMUSG00000034518 AllianceGenome:MGI:1918073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmgb2l1; 4733401K04Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be part of NURF complex. Is expressed in several structures, including brain; early conceptus; gonad; thymus; and ureter. Orthologous to human HMGXB4 (HMG-box containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.5), limb E14.5 (RPKM 8.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hmgxb4 in Genome Data Viewer
Location:
8; 8 C1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (75720262..75758606)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (74993650..75031978)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene intestine specific homeobox Neighboring gene predicted gene, 53440 Neighboring gene target of myb1 trafficking protein Neighboring gene dpy-30 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice. He X, et al. Proc Natl Acad Sci U S A, 2021 Feb 16. PMID 33563757, Free PMC Article
  2. Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1. Zhou J, et al. J Biol Chem, 2010 Jul 23. PMID 20511232, Free PMC Article
  3. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
  4. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  5. Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Chung YC, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20932939

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice.
    Title: Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice.
  2. the first evidence of this novel HMG2L1 molecule playing an important role in attenuating smooth muscle differentiation
    Title: Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • E430025G12

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NURF complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HMG domain-containing protein 4
Names
high mobility group box 2-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316753.2 → NP_001303682.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL603864
    UniProtKB/TrEMBL
    Q80Y32
    Conserved Domains (2) summary
    cd00084
    Location:291 → 354
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:1 → 123
    DUF4171; Domain of unknown function (DUF4171)

  2. NM_001316754.2 → NP_001303683.1  HMG domain-containing protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon in place of the first five exons compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL603864
    Consensus CDS
    CCDS85564.1
    UniProtKB/TrEMBL
    Q80Y32, Q8BTT5
    Related
    ENSMUSP00000105566.2, ENSMUST00000109940.2
    Conserved Domains (1) summary
    cd00084
    Location:3 → 66
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  3. NM_001415023.1 → NP_001401952.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603864

  4. NM_001415024.1 → NP_001401953.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603864

  5. NM_001415025.1 → NP_001401954.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603864

  6. NM_001415026.1 → NP_001401955.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603864

  7. NM_001415027.1 → NP_001401956.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603864

  8. NM_001415028.1 → NP_001401957.1  HMG domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL603864

  9. NM_178017.3 → NP_821136.1  HMG domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_821136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL603864
    Consensus CDS
    CCDS22422.1
    UniProtKB/TrEMBL
    Q80Y32
    Related
    ENSMUSP00000045126.8, ENSMUST00000041759.14
    Conserved Domains (2) summary
    cd00084
    Location:400 → 463
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:107 → 225
    DUF4171; Domain of unknown function (DUF4171)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    75720262..75758606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531364.3 → XP_006531427.1  HMG domain-containing protein 4 isoform X1

    Conserved Domains (2) summary
    cd00084
    Location:291 → 354
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:1 → 123
    DUF4171; Domain of unknown function (DUF4171)

  2. XM_006531362.4 → XP_006531425.2  HMG domain-containing protein 4 isoform X1

    Conserved Domains (2) summary
    cd00084
    Location:291 → 354
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:1 → 123
    DUF4171; Domain of unknown function (DUF4171)
Nucleotide Protein Strain
Heading Accession and Version

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