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Hmgxb4 HMG box domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 70823, updated on 7-Aug-2018

Summary

Official Symbol
Hmgxb4provided by MGI
Official Full Name
HMG box domain containing 4provided by MGI
Primary source
MGI:MGI:1918073
See related
Ensembl:ENSMUSG00000034518 Vega:OTTMUSG00000017305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmgb2l1; AI316803; 4733401K04Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.5), limb E14.5 (RPKM 8.1) and 28 other tissues See more
Orthologs

Genomic context

See Hmgxb4 in Genome Data Viewer
Location:
8; 8 C1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (74993518..75031978)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (77517602..77555871)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene Luc7 homolog-like pseudogene Neighboring gene intestine specific homeobox Neighboring gene dpy-30 homolog pseudogene Neighboring gene target of myb1 trafficking protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • E430025G12

Gene Ontology Provided by MGI

Component Evidence Code Pubs
NURF complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
HMG domain-containing protein 4
Names
high mobility group box 2-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316753.1NP_001303682.1  HMG domain-containing protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL603864, BC048188, BC049800, CN456159
    UniProtKB/TrEMBL
    Q80Y32
    Conserved Domains (2) summary
    cd00084
    Location:291354
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:1116
    DUF4171; Domain of unknown function (DUF4171)
  2. NM_001316754.1NP_001303683.1  HMG domain-containing protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon in place of the first five exons compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC048188, BC049800, BY035054
    Consensus CDS
    CCDS85564.1
    UniProtKB/TrEMBL
    Q80Y32, Q8BTT5
    Related
    ENSMUSP00000105566.1, OTTMUSP00000018887, ENSMUST00000109940.1, OTTMUST00000042003
    Conserved Domains (1) summary
    cd00084
    Location:366
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  3. NM_178017.2NP_821136.1  HMG domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_821136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC048188, BC049800, CN456159
    Consensus CDS
    CCDS22422.1
    UniProtKB/TrEMBL
    Q80Y32
    Related
    ENSMUSP00000045126.7, OTTMUSP00000018886, ENSMUST00000041759.13, OTTMUST00000042002
    Conserved Domains (2) summary
    cd00084
    Location:400463
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:107225
    DUF4171; Domain of unknown function (DUF4171)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    74993518..75031978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531362.3XP_006531425.2  HMG domain-containing protein 4 isoform X1

    Conserved Domains (2) summary
    cd00084
    Location:291354
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:1116
    DUF4171; Domain of unknown function (DUF4171)
  2. XM_006531364.1XP_006531427.1  HMG domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006531427.1

    Conserved Domains (2) summary
    cd00084
    Location:291354
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    pfam13775
    Location:1116
    DUF4171; Domain of unknown function (DUF4171)

RNA

  1. XR_001778467.1 RNA Sequence

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