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Zdhhc1 zinc finger, DHHC domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70796, updated on 8-Feb-2024

Summary

Official Symbol
Zdhhc1provided by MGI
Official Full Name
zinc finger, DHHC domain containing 1provided by MGI
Primary source
MGI:MGI:1918046
See related
Ensembl:ENSMUSG00000039199 AllianceGenome:MGI:1918046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-1; 4432412D04Rik
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Acts upstream of or within protein palmitoylation. Located in endosome membrane. Is expressed in several structures, including adrenal gland; brain; genitourinary system; heart; and lung. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 28.6), ovary adult (RPKM 27.7) and 24 other tissues See more
Orthologs
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Genomic context

See Zdhhc1 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106199055..106223694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105472419..105497062, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 36 Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC1
Names
probable palmitoyltransferase ZDHHC1
zinc finger DHHC domain-containing protein 1
NP_001344181.1
NP_001365935.1
NP_001365936.1
NP_001365937.1
NP_001365938.1
NP_001365939.1
NP_001365940.1
NP_780369.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357252.2NP_001344181.1  palmitoyltransferase ZDHHC1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 5, encodes isoform 2.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/TrEMBL
    B7ZMY5
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase
  2. NM_001379006.1NP_001365935.1  palmitoyltransferase ZDHHC1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/Swiss-Prot
    Q0VE36, Q8BJ24, Q8R0N9
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase
  3. NM_001379007.1NP_001365936.1  palmitoyltransferase ZDHHC1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/Swiss-Prot
    Q0VE36, Q8BJ24, Q8R0N9
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase
  4. NM_001379008.1NP_001365937.1  palmitoyltransferase ZDHHC1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC090480, AC151573
    UniProtKB/TrEMBL
    B7ZMY5
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase
  5. NM_001379009.1NP_001365938.1  palmitoyltransferase ZDHHC1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform 3.
    Source sequence(s)
    AC090480, AC151573
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase
  6. NM_001379010.1NP_001365939.1  palmitoyltransferase ZDHHC1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform 3.
    Source sequence(s)
    AC090480, AC151573
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase
  7. NM_001379011.1NP_001365940.1  palmitoyltransferase ZDHHC1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform 3.
    Source sequence(s)
    AC090480, AC151573
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase
  8. NM_175160.5NP_780369.1  palmitoyltransferase ZDHHC1 isoform 1

    See identical proteins and their annotated locations for NP_780369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC090480, AC151573
    Consensus CDS
    CCDS22603.1
    UniProtKB/Swiss-Prot
    Q0VE36, Q8BJ24, Q8R0N9
    Related
    ENSMUSP00000148381.2, ENSMUST00000212303.2
    Conserved Domains (1) summary
    pfam01529
    Location:126281
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_166407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090480, AC151573
  2. NR_166408.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090480, AC151573
  3. NR_166409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090480, AC151573

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106199055..106223694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)