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TIMP4 TIMP metallopeptidase inhibitor 4 [ Homo sapiens (human) ]

Gene ID: 7079, updated on 15-Sep-2022

Summary

Official Symbol
TIMP4provided by HGNC
Official Full Name
TIMP metallopeptidase inhibitor 4provided by HGNC
Primary source
HGNC:HGNC:11823
See related
Ensembl:ENSG00000157150 MIM:601915; AllianceGenome:HGNC:11823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIMP-4
Summary
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 76.2) and brain (RPKM 10.2) See more
Orthologs
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Genomic context

See TIMP4 in Genome Data Viewer
Location:
3p25.2
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12153068..12158912, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12151357..12157146, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12194568..12200412, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene actin gamma 1 pseudogene 12 Neighboring gene Sharpr-MPRA regulatory region 15359 Neighboring gene MT-CO1 pseudogene 5 Neighboring gene glutathione S-transferase mu 5 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ovulation cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
metalloproteinase inhibitor 4
Names
tissue inhibitor of metalloproteinase 4
tissue inhibitor of metalloproteinases 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003256.4NP_003247.1  metalloproteinase inhibitor 4 precursor

    See identical proteins and their annotated locations for NP_003247.1

    Status: REVIEWED

    Source sequence(s)
    BC010553
    Consensus CDS
    CCDS2608.1
    UniProtKB/Swiss-Prot
    B2R7K6, Q99727
    Related
    ENSP00000287814.4, ENST00000287814.5
    Conserved Domains (1) summary
    cd03585
    Location:30213
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    12153068..12158912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    12151357..12157146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)