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Nolc1 nucleolar and coiled-body phosphoprotein 1 [ Mus musculus (house mouse) ]

Gene ID: 70769, updated on 9-May-2024

Summary

Official Symbol
Nolc1provided by MGI
Official Full Name
nucleolar and coiled-body phosphoprotein 1provided by MGI
Primary source
MGI:MGI:1918019
See related
Ensembl:ENSMUSG00000015176 AllianceGenome:MGI:1918019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P130; NOPP130; NOPP140
Summary
Predicted to enable several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Acts upstream of or within nucleolus organization. Located in Cajal body and nucleolus. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; and cortical plate. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 39.7), liver E14.5 (RPKM 31.2) and 23 other tissues See more
Orthologs
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Genomic context

See Nolc1 in Genome Data Viewer
Location:
19 C3; 19 38.75 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46064286..46073982)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46075847..46085543)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46294 Neighboring gene STARR-positive B cell enhancer ABC_E5707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46114769-46114954 Neighboring gene STARR-positive B cell enhancer ABC_E1527 Neighboring gene LIM domain binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E7666 Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator-related 1 Neighboring gene STARR-positive B cell enhancer ABC_E11034 Neighboring gene STARR-positive B cell enhancer ABC_E101 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain transcription factor 3 Neighboring gene golgi-specific brefeldin A-resistance factor 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • mKIAA0035, 3230402K17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TFIIB-class transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables box C/D methylation guide snoRNP complex binding ISO
Inferred from Sequence Orthology
more info
 
enables box C/D sno(s)RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables box H/ACA snoRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables box H/ACA snoRNP complex binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
part_of box C/D methylation guide snoRNP complex ISO
Inferred from Sequence Orthology
more info
 
part_of box H/ACA snoRNP complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of small nuclear ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
nucleolar and coiled-body phosphoprotein 1
Names
140 kDa nucleolar phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039351.2NP_001034440.1  nucleolar and coiled-body phosphoprotein 1 isoform B

    See identical proteins and their annotated locations for NP_001034440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the central coding region, compared to variant 3. The encoded isoform (B) is shorter, compared to isoform C.
    Source sequence(s)
    AK029150, AK147118, BE992617, BY031361
    Consensus CDS
    CCDS89406.1
    UniProtKB/TrEMBL
    A0A286YDA2, A0A286YDV7
    Related
    ENSMUSP00000153329.2, ENSMUST00000223728.2
    Conserved Domains (1) summary
    pfam05022
    Location:625691
    SRP40_C; SRP40, C-terminal domain
  2. NM_001039352.2NP_001034441.1  nucleolar and coiled-body phosphoprotein 1 isoform C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (C).
    Source sequence(s)
    AK034817, BE992617, BY031361, CF750495
    Consensus CDS
    CCDS38006.1
    UniProtKB/Swiss-Prot
    E9Q5C9, Q3TKZ9, Q3U6W2, Q3UBB6, Q3UI16, Q6ZQK6, Q8CE21
    UniProtKB/TrEMBL
    A0A286YDV7
    Related
    ENSMUSP00000128331.2, ENSMUST00000165017.2
    Conserved Domains (1) summary
    pfam05022
    Location:627693
    SRP40_C; SRP40, C-terminal domain
  3. NM_001039353.2NP_001034442.1  nucleolar and coiled-body phosphoprotein 1 isoform D

    See identical proteins and their annotated locations for NP_001034442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (D) is shorter, compared to isoform C.
    Source sequence(s)
    AK034817, AK147118, BE992617, BY031361
    UniProtKB/TrEMBL
    A0A286YDV7
    Conserved Domains (1) summary
    pfam05022
    Location:626692
    SRP40_C; SRP40, C-terminal domain
  4. NM_053086.3NP_444316.2  nucleolar and coiled-body phosphoprotein 1 isoform A

    See identical proteins and their annotated locations for NP_444316.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (A) is shorter, compared to isoform C.
    Source sequence(s)
    AK147118, AK166753, BE992617, BY031361
    Consensus CDS
    CCDS89405.1
    UniProtKB/TrEMBL
    A0A286YDT3, A0A286YDV7
    Related
    ENSMUSP00000153545.2, ENSMUST00000225780.2
    Conserved Domains (1) summary
    pfam05022
    Location:626692
    SRP40_C; SRP40, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46064286..46073982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)