U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nolc1 nucleolar and coiled-body phosphoprotein 1 [ Mus musculus (house mouse) ]

Gene ID: 70769, updated on 9-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Nolc1provided by MGI
Official Full Name
nucleolar and coiled-body phosphoprotein 1provided by MGI
Primary source
MGI:MGI:1918019
See related
Ensembl:ENSMUSG00000015176 AllianceGenome:MGI:1918019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P130; NOPP130; NOPP140
Summary
Predicted to enable several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Acts upstream of or within nucleolus organization. Located in Cajal body and nucleolus. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; and cortical plate. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 39.7), liver E14.5 (RPKM 31.2) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nolc1 in Genome Data Viewer
Location:
19; 19 C3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46064286..46073982)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46075847..46085543)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ES cell cis-regulatory motif 2c Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator-related 1 Neighboring gene elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Neighboring gene paired-like homeodomain transcription factor 3 Neighboring gene golgi-specific brefeldin A-resistance factor 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus. Yuan F, et al. Aging Cell, 2017 Aug. PMID 28493459, Free PMC Article
  2. Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development. Koné MC, et al. Biol Reprod, 2016 Apr. PMID 26984997
  3. NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression. Hwang YC, et al. Am J Pathol, 2009 Jul. PMID 19541936, Free PMC Article
  4. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. Tucker KE, et al. J Cell Biol, 2001 Jul 23. PMID 11470819, Free PMC Article
  5. Phosphorylation of proteins by inositol pyrophosphates. Saiardi A, et al. Science, 2004 Dec 17. PMID 15604408

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
    Title: Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
  2. UBF and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments.
    Title: Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • mKIAA0035, 3230402K17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TFIIB-class transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables box C/D RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables box C/D snoRNP complex binding ISO
Inferred from Sequence Orthology
more info
  
enables box H/ACA snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables box H/ACA snoRNP complex binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in box H/ACA RNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in neural crest cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleolus organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of box C/D RNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of box H/ACA snoRNP complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small nuclear ribonucleoprotein complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
nucleolar and coiled-body phosphoprotein 1
Names
140 kDa nucleolar phosphoprotein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039351.2 → NP_001034440.1  nucleolar and coiled-body phosphoprotein 1 isoform B

    See identical proteins and their annotated locations for NP_001034440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the central coding region, compared to variant 3. The encoded isoform (B) is shorter, compared to isoform C.
    Source sequence(s)
    AK029150, AK147118, BE992617, BY031361
    Consensus CDS
    CCDS89406.1
    UniProtKB/Swiss-Prot
    E9Q5C9
    UniProtKB/TrEMBL
    A0A286YDA2
    Related
    ENSMUSP00000153329.2, ENSMUST00000223728.2
    Conserved Domains (1) summary
    pfam05022
    Location:625 → 691
    SRP40_C; SRP40, C-terminal domain

  2. NM_001039352.2 → NP_001034441.1  nucleolar and coiled-body phosphoprotein 1 isoform C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (C).
    Source sequence(s)
    AK034817, BE992617, BY031361, CF750495
    Consensus CDS
    CCDS38006.1
    UniProtKB/Swiss-Prot
    E9Q5C9, Q8CE21
    Related
    ENSMUSP00000128331.2, ENSMUST00000165017.2
    Conserved Domains (1) summary
    pfam05022
    Location:627 → 693
    SRP40_C; SRP40, C-terminal domain

  3. NM_001039353.2 → NP_001034442.1  nucleolar and coiled-body phosphoprotein 1 isoform D

    See identical proteins and their annotated locations for NP_001034442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (D) is shorter, compared to isoform C.
    Source sequence(s)
    AK034817, AK147118, BE992617, BY031361
    UniProtKB/Swiss-Prot
    E9Q5C9
    Conserved Domains (1) summary
    pfam05022
    Location:626 → 692
    SRP40_C; SRP40, C-terminal domain

  4. NM_053086.3 → NP_444316.2  nucleolar and coiled-body phosphoprotein 1 isoform A

    See identical proteins and their annotated locations for NP_444316.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (A) is shorter, compared to isoform C.
    Source sequence(s)
    AK147118, AK166753, BE992617, BY031361
    Consensus CDS
    CCDS89405.1
    UniProtKB/Swiss-Prot
    E9Q5C9
    UniProtKB/TrEMBL
    A0A286YDT3
    Related
    ENSMUSP00000153545.2, ENSMUST00000225780.2
    Conserved Domains (1) summary
    pfam05022
    Location:626 → 692
    SRP40_C; SRP40, C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46064286..46073982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q5C9.1 GenPept UniProtKB/Swiss-Prot:E9Q5C9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous