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Prpf3 pre-mRNA processing factor 3 [ Mus musculus (house mouse) ]

Gene ID: 70767, updated on 2-Jul-2024

Summary

Official Symbol
Prpf3provided by MGI
Official Full Name
pre-mRNA processing factor 3provided by MGI
Primary source
MGI:MGI:1918017
See related
Ensembl:ENSMUSG00000015748 AllianceGenome:MGI:1918017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3632413F13Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in Cajal body; cytosol; and nuclear speck. Predicted to be part of U2-type precatalytic spliceosome and U4/U6 x U5 tri-snRNP complex. Is expressed in central nervous system; genitourinary system; gut gland; heart; and sensory organ. Used to study retinitis pigmentosa 18. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 18. Orthologous to human PRPF3 (pre-mRNA processing factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.3), liver E14 (RPKM 7.8) and 24 other tissues See more
Orthologs
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Genomic context

See Prpf3 in Genome Data Viewer
Location:
3 F2.1; 3 41.25 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95737436..95763197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95830124..95855885, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene STARR-seq mESC enhancer starr_08396 Neighboring gene predicted gene, 29948 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene RIKEN cDNA C920021L13 gene Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene cDNA sequence BC028528 Neighboring gene circadian associated repressor of transcription

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
U4/U6 small nuclear ribonucleoprotein Prp3
Names
PRP3 pre-mRNA processing factor 3 homolog
pre-mRNA-splicing factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316751.2NP_001303680.1  U4/U6 small nuclear ribonucleoprotein Prp3

    Status: VALIDATED

    Source sequence(s)
    AC093317, AK167435, BY308032
    Consensus CDS
    CCDS17621.1
    UniProtKB/Swiss-Prot
    Q3TJH4, Q922U1, Q9D6C6
    UniProtKB/TrEMBL
    Q3UT19
    Related
    ENSMUSP00000015892.8, ENSMUST00000015892.14
    Conserved Domains (3) summary
    smart00311
    Location:373
    PWI; domain in splicing factors
    pfam06544
    Location:546673
    DUF1115; Protein of unknown function (DUF1115)
    pfam08572
    Location:309521
    PRP3; pre-mRNA processing factor 3 (PRP3)
  2. NM_027541.5NP_081817.2  U4/U6 small nuclear ribonucleoprotein Prp3

    See identical proteins and their annotated locations for NP_081817.2

    Status: VALIDATED

    Source sequence(s)
    AC093317
    Consensus CDS
    CCDS17621.1
    UniProtKB/Swiss-Prot
    Q3TJH4, Q922U1, Q9D6C6
    UniProtKB/TrEMBL
    Q3UT19
    Related
    ENSMUSP00000124950.2, ENSMUST00000161476.8
    Conserved Domains (3) summary
    smart00311
    Location:373
    PWI; domain in splicing factors
    pfam06544
    Location:546673
    DUF1115; Protein of unknown function (DUF1115)
    pfam08572
    Location:309521
    PRP3; pre-mRNA processing factor 3 (PRP3)

RNA

  1. NR_151629.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093317

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95737436..95763197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502081.3XP_006502144.1  U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1

    UniProtKB/TrEMBL
    Q3UT19
    Conserved Domains (2) summary
    pfam06544
    Location:411538
    DUF1115; Protein of unknown function (DUF1115)
    pfam08572
    Location:173386
    PRP3; pre-mRNA processing factor 3 (PRP3)