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CXCR4 C-X-C motif chemokine receptor 4 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 707329, updated on 17-Aug-2024
Official Symbol
CXCR4provided by VGNC
Official Full Name
C-X-C motif chemokine receptor 4provided by VGNC
Primary source
VGNC:VGNC:71572
See related
Ensembl:ENSMMUG00000011918
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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See CXCR4 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
2
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (21291083..21294316, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (21637417..21640662, complement)

Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene glycoprotein endo-alpha-1,2-mannosidase-like protein pseudogene Neighboring gene aspartyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC114671318 Neighboring gene uncharacterized LOC106992562 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. New widespread CXCR4 allele in rhesus macaques does not predict subspecies or clinical evolution. Prétet JL, et al. AIDS Res Hum Retroviruses, 1998 May 1. PMID 9591719
  2. Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus. Ho SH, et al. J Virol, 2008 Jun. PMID 18385246, Free PMC Article
  3. Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. Chen Z, et al. J Virol, 1997 Apr. PMID 9060623, Free PMC Article
  4. Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration. Hong SG, et al. Blood, 2020 Dec 3. PMID 32659786, Free PMC Article
  5. CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells. Jin J, et al. Ophthalmic Res, 2013. PMID 23549077

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration.
    Title: Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration.
  2. The increased CXCR4 and CXCR7 expression resulted in increased SDF-1-induced RF/6A cell migration and tube formation.
    Title: TGF-β1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression.
  3. The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
    Title: CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells.
  4. These findings suggest that FBLN5 may interfere with choroidal neovascularization by downregulating VEGF, CXCR4, and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.
    Title: Overexpression of fibulin-5 in retinal pigment epithelial cells inhibits cell proliferation and migration and downregulates VEGF, CXCR4, and TGFB1 expression in cocultured choroidal endothelial cells.
  5. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
    Title: Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
C-X-C chemokine receptor type 4
Names
CXC-R4
CXCR-4
LESTR
SDF-1 receptor
chemokine (C-X-C motif) receptor 4
fusin
leukocyte-derived seven transmembrane domain receptor
stromal cell-derived factor 1 receptor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042645.1 → NP_001036110.1  C-X-C chemokine receptor type 4

    See identical proteins and their annotated locations for NP_001036110.1

    Status: PROVISIONAL

    Source sequence(s)
    AF001928
    UniProtKB/Swiss-Prot
    O02745, O46428, P79394
    UniProtKB/TrEMBL
    A0A1D5QA04, H9ZDD5
    Related
    ENSMMUP00000044872.2, ENSMMUT00000078825.2
    Conserved Domains (2) summary
    cd15179
    Location:39 → 313
    7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam12109
    Location:6 → 38
    CXCR4_N; CXCR4 Chemokine receptor N terminal

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041765.1 Reference Mmul_10 Primary Assembly

    Range
    21291083..21294316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79394.1 GenPept UniProtKB/Swiss-Prot:P79394

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials