U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TIA1 TIA1 cytotoxic granule associated RNA binding protein [ Homo sapiens (human) ]

Gene ID: 7072, updated on 12-Aug-2026
Official Symbol
TIA1provided by HGNC
Official Full Name
TIA1 cytotoxic granule associated RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:11802
See related
Ensembl:ENSG00000116001 MIM:603518; AllianceGenome:HGNC:11802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDM; ALS26; TIA-1
Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in endometrium (RPKM 25.4), ovary (RPKM 18.9) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TIA1 in Genome Data Viewer
Location:
2p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70209444..70248793, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70221187..70260535, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70436576..70475925, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70350937-70351742 Neighboring gene Sharpr-MPRA regulatory region 3961 Neighboring gene long independently transcribed non-coding RNA 1816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70365403-70365944 Neighboring gene Sharpr-MPRA regulatory region 12614 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70368111-70368650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70376065-70376594 Neighboring gene chromosome 2 open reading frame 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:70418013-70418598 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70474526-70475341 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70475342-70476156 Neighboring gene tRNA-Gly (anticodon CCC) 2-1 Neighboring gene microRNA 1285-2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Primary Cutaneous T-cell Lymphoma With Coexpression of T-Cell Receptors αβ and γδ. Parekh V, et al. Am J Dermatopathol, 2016 Jan. PMID 26258878
  2. Non-HTLV-1-associated primary gastric T-cell lymphomas show cytotoxic activity: clinicopathological, immunohistochemical characteristics and TIA-1 expression in 31 cases. Hatano B, et al. Histopathology, 2002 Nov. PMID 12405910
  3. [Immunophenotype and differential diagnosis of Hodgkin's lymphoma]. Liu Y, et al. Zhonghua Xue Ye Xue Za Zhi, 2002 Oct. PMID 12482349
  4. Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop. Santucci M, et al. Cancer, 2003 Feb 1. PMID 12548603
  5. Cytotoxic activity of T- and NK-cell lymphoma cells is not dependent on a mature cytotoxic phenotype. Boehrer S, et al. Leuk Lymphoma, 2002 Dec. PMID 12613525

See all (449) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Defining the landscape of TIA1 and SQSTM1 digenic myopathy.
    Title: Defining the landscape of TIA1 and SQSTM1 digenic myopathy.
  2. The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics.
    Title: The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics.
  3. RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.
    Title: RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.
  4. Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients.
    Title: Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients.
  5. Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein.
    Title: Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein.
  6. The role of peritumoral CD8 + /TIA1 + lymphocytes in hepatocellular carcinoma aggressiveness and recurrence after surgical resection.
    Title: The role of peritumoral CD8 + /TIA1 + lymphocytes in hepatocellular carcinoma aggressiveness and recurrence after surgical resection.
  7. ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures.
    Title: ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures.
  8. Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.
    Title: Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.
  9. Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.
    Title: Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.
  10. The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease.
    Title: The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease.
Submit: New GeneRIF Correction See all GeneRIFs (80)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
MedGen: C5436882 OMIM: 619133 GeneReviews: Not available
Compare labs
Welander distal myopathy
MedGen: C0221054 OMIM: 604454 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat co-localizes with TIA1 in cytoplasmic stress granules under stress conditions PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR AU-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-RNA adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cytoplasmic stress granule assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to cytoplasmic stress granule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cytotoxic granule associated RNA binding protein TIA1
Names
T-cell-restricted intracellular antigen-1
p40-TIA-1 (containing p15-TIA-1)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029967.1 RefSeqGene

    Range
    5020..44204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351508.2 → NP_001338437.1  cytotoxic granule associated RNA binding protein TIA1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Consensus CDS
    CCDS86847.1
    UniProtKB/TrEMBL
    A0ACI8Q0M7, F8W8I6
    Related
    ENSP00000282574.4, ENST00000282574.9
    Conserved Domains (3) summary
    cd12620
    Location:214 → 286
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12615
    Location:8 → 81
    RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:104 → 181
    RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

  2. NM_001351509.2 → NP_001338438.1  cytotoxic granule associated RNA binding protein TIA1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q0M7, A0ACI8Q5B2
    Related
    ENSP00000551420.1, ENST00000881361.2
    Conserved Domains (3) summary
    cd12618
    Location:96 → 175
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:205 → 278
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:8 → 83
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001351510.2 → NP_001338439.1  cytotoxic granule associated RNA binding protein TIA1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q052, A0ACI8Q0M7
    Related
    ENSP00000551417.1, ENST00000881358.1
    Conserved Domains (3) summary
    cd12620
    Location:203 → 275
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12615
    Location:8 → 81
    RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:93 → 170
    RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

  4. NM_001351511.1 → NP_001338440.1  cytotoxic granule associated RNA binding protein TIA1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q0M7
    Conserved Domains (3) summary
    TIGR01628
    Location:11 → 342
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:177 → 249
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12618
    Location:67 → 144
    RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

  5. NM_001351512.1 → NP_001338441.1  cytotoxic granule associated RNA binding protein TIA1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q0M7
    Conserved Domains (3) summary
    cd12618
    Location:59 → 138
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:168 → 241
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl25887
    Location:13 → 333
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  6. NM_001351513.1 → NP_001338442.1  cytotoxic granule associated RNA binding protein TIA1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q0M7
    Conserved Domains (3) summary
    cd12618
    Location:57 → 136
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:166 → 239
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl25887
    Location:11 → 331
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  7. NM_001351514.2 → NP_001338443.1  cytotoxic granule associated RNA binding protein TIA1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q0M7
    Conserved Domains (3) summary
    cd12618
    Location:29 → 108
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:138 → 211
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:1 → 23
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_001351515.2 → NP_001338444.1  cytotoxic granule associated RNA binding protein TIA1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q261
    Conserved Domains (2) summary
    cd12620
    Location:113 → 185
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12618
    Location:3 → 80
    RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

  9. NM_001351516.2 → NP_001338445.1  cytotoxic granule associated RNA binding protein TIA1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    C9JTN7
    Related
    ENSP00000757991.1, ENST00001088185.1
    Conserved Domains (2) summary
    cd12618
    Location:105 → 184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:8 → 81
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. NM_001351517.2 → NP_001338446.1  cytotoxic granule associated RNA binding protein TIA1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q261
    Conserved Domains (2) summary
    cl17169
    Location:74 → 147
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:4 → 238
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  11. NM_001351518.2 → NP_001338447.1  cytotoxic granule associated RNA binding protein TIA1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC016700, BC015944
    Consensus CDS
    CCDS86846.1
    Related
    ENSP00000413751.2, ENST00000416149.7
    Conserved Domains (2) summary
    cd12618
    Location:105 → 184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:8 → 81
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. NM_001351519.2 → NP_001338448.1  cytotoxic granule associated RNA binding protein TIA1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    H7BY49
    Related
    ENSP00000768211.1, ENST00001098405.1
    Conserved Domains (1) summary
    TIGR01628
    Location:9 → 156
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  13. NM_001351520.2 → NP_001338449.1  cytotoxic granule associated RNA binding protein TIA1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Related
    ENST00000477044.6
    Conserved Domains (1) summary
    cl17169
    Location:8 → 83
    RRM_SF; RNA recognition motif (RRM) superfamily

  14. NM_001351521.2 → NP_001338450.1  cytotoxic granule associated RNA binding protein TIA1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    H7BY49
    Related
    ENSP00000757995.1, ENST00001088189.1
    Conserved Domains (1) summary
    cl17169
    Location:8 → 81
    RRM_SF; RNA recognition motif (RRM) superfamily

  15. NM_001351522.2 → NP_001338451.1  cytotoxic granule associated RNA binding protein TIA1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Consensus CDS
    CCDS86848.1
    UniProtKB/TrEMBL
    E5RGV5
    Related
    ENSP00000757993.1, ENST00001088187.1
    Conserved Domains (2) summary
    cd12615
    Location:8 → 81
    RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:104 → 133
    RRM_SF; RNA recognition motif (RRM) superfamily

  16. NM_001351523.2 → NP_001338452.1  cytotoxic granule associated RNA binding protein TIA1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Conserved Domains (1) summary
    cl17169
    Location:29 → 82
    RRM_SF; RNA recognition motif (RRM) superfamily

  17. NM_001351524.2 → NP_001338453.1  cytotoxic granule associated RNA binding protein TIA1 isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variant 20, encodes isoform 19.
    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q261
    Conserved Domains (3) summary
    TIGR01628
    Location:4 → 239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74 → 146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:1 → 41
    RRM_SF; RNA recognition motif (RRM) superfamily

  18. NM_001351525.2 → NP_001338454.1  cytotoxic granule associated RNA binding protein TIA1 isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 19, encodes isoform 19.
    Source sequence(s)
    AC016700
    UniProtKB/TrEMBL
    A0ACI8Q261
    Conserved Domains (3) summary
    TIGR01628
    Location:4 → 239
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12620
    Location:74 → 146
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:1 → 41
    RRM_SF; RNA recognition motif (RRM) superfamily

  19. NM_022037.4 → NP_071320.2  cytotoxic granule associated RNA binding protein TIA1 isoform 1

    See identical proteins and their annotated locations for NP_071320.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is missing exon 5, which is included in transcript variant 2, resulting in the shorter isoform (1).
    Source sequence(s)
    AC016700
    Consensus CDS
    CCDS1900.1
    UniProtKB/TrEMBL
    A0ACI8Q0M7
    Related
    ENSP00000404023.2, ENST00000415783.7
    Conserved Domains (3) summary
    cd12620
    Location:203 → 275
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12615
    Location:8 → 81
    RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:93 → 170
    RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

  20. NM_022173.4 → NP_071505.2  cytotoxic granule associated RNA binding protein TIA1 isoform 2

    See identical proteins and their annotated locations for NP_071505.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes exon 5, which is missing in transcript variant 1, resulting in the longer isoform (2).
    Source sequence(s)
    AC016700
    Consensus CDS
    CCDS1901.1
    UniProtKB/Swiss-Prot
    P31483, Q53SS9, Q96B58
    UniProtKB/TrEMBL
    A0ACI8Q0M7
    Related
    ENSP00000401371.2, ENST00000433529.7
    Conserved Domains (3) summary
    cd12620
    Location:214 → 286
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12615
    Location:8 → 81
    RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:104 → 181
    RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

RNA

  1. NR_147216.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  2. NR_147217.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  3. NR_147218.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  4. NR_147219.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  5. NR_147220.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  6. NR_147221.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Related
    ENST00001088177.1

  7. NR_147222.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  8. NR_147223.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  9. NR_147224.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  10. NR_147225.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  11. NR_147226.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Related
    ENST00001044782.1

  12. NR_147227.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Related
    ENST00001005206.1

  13. NR_147228.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Related
    ENST00001088172.1

  14. NR_147229.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

  15. NR_147230.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Related
    ENST00001044792.1

  16. NR_147231.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700
    Related
    ENST00001088176.1

  17. NR_147232.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016700

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    70209444..70248793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264528.6 → XP_005264585.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

    See identical proteins and their annotated locations for XP_005264585.1

    UniProtKB/TrEMBL
    A0ACI8Q0M7
    Conserved Domains (3) summary
    cd12618
    Location:40 → 119
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:149 → 222
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cl17169
    Location:1 → 23
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_047445625.1 → XP_047301581.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

  3. XM_047445630.1 → XP_047301586.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    UniProtKB/TrEMBL
    A0ACI8Q261

  4. XM_047445628.1 → XP_047301584.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    UniProtKB/TrEMBL
    A0ACI8Q261

  5. XM_047445626.1 → XP_047301582.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

  6. XM_047445632.1 → XP_047301588.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    UniProtKB/TrEMBL
    A0ACI8Q261

  7. XM_047445631.1 → XP_047301587.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    UniProtKB/TrEMBL
    A0ACI8Q261

  8. XM_047445627.1 → XP_047301583.1  cytotoxic granule associated RNA binding protein TIA1 isoform X3

  9. XM_047445629.1 → XP_047301585.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    UniProtKB/TrEMBL
    A0ACI8Q261

  10. XM_047445634.1 → XP_047301590.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

    Related
    ENSP00000675036.1, ENST00001005219.1

  11. XM_047445633.1 → XP_047301589.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

    Related
    ENSP00000675033.1, ENST00001005216.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    70221187..70260535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343587.1 → XP_054199562.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

    UniProtKB/TrEMBL
    A0ACI8Q0M7

  2. XM_054343588.1 → XP_054199563.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

  3. XM_054343593.1 → XP_054199568.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    UniProtKB/TrEMBL
    A0ACI8Q261

  4. XM_054343591.1 → XP_054199566.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    UniProtKB/TrEMBL
    A0ACI8Q261

  5. XM_054343589.1 → XP_054199564.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

  6. XM_054343595.1 → XP_054199570.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    UniProtKB/TrEMBL
    A0ACI8Q261

  7. XM_054343594.1 → XP_054199569.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    UniProtKB/TrEMBL
    A0ACI8Q261

  8. XM_054343590.1 → XP_054199565.1  cytotoxic granule associated RNA binding protein TIA1 isoform X3

  9. XM_054343592.1 → XP_054199567.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    UniProtKB/TrEMBL
    A0ACI8Q261

  10. XM_054343597.1 → XP_054199572.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

  11. XM_054343596.1 → XP_054199571.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31483.3 GenPept UniProtKB/Swiss-Prot:P31483

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous