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Gpr137c G protein-coupled receptor 137C [ Mus musculus (house mouse) ]

Gene ID: 70713, updated on 26-Sep-2022

Summary

Official Symbol
Gpr137cprovided by MGI
Official Full Name
G protein-coupled receptor 137Cprovided by MGI
Primary source
MGI:MGI:1917963
See related
Ensembl:ENSMUSG00000049092 AllianceGenome:MGI:1917963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm908; TM7SF1L2; 6330416L11Rik
Summary
Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Predicted to be active in lysosomal membrane. Orthologous to human GPR137C (G protein-coupled receptor 137C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 4.5), whole brain E14.5 (RPKM 3.6) and 16 other tissues See more
Orthologs
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Genomic context

See Gpr137c in Genome Data Viewer
Location:
14; 14 C1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45457142..45520192)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45219685..45282735)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene predicted gene, 34362 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G protein-coupled receptor 137C
Names
G protein-coupled receptor TM7SF1L2
integral membrane protein GPR137C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027518.2NP_081794.2  G protein-coupled receptor 137C

    Status: VALIDATED

    Source sequence(s)
    AC154575
    Consensus CDS
    CCDS49464.1
    UniProtKB/Swiss-Prot
    E9Q343
    UniProtKB/TrEMBL
    E9Q343
    Related
    ENSMUSP00000120015.2, ENSMUST00000146150.3
    Conserved Domains (2) summary
    cd21464
    Location:4466
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:36357
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    45457142..45520192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519544.4XP_006519607.1  G protein-coupled receptor 137C isoform X1

  2. XM_017316191.3XP_017171680.1  G protein-coupled receptor 137C isoform X3

    UniProtKB/TrEMBL
    A0A2I3BPD5
    Related
    ENSMUSP00000153737.2, ENSMUST00000227009.2
  3. XM_017316190.2XP_017171679.1  G protein-coupled receptor 137C isoform X2

    Related
    ENSMUSP00000153906.2, ENSMUST00000227056.2
  4. XM_017316192.2XP_017171681.1  G protein-coupled receptor 137C isoform X4

RNA

  1. XR_004938445.1 RNA Sequence

  2. XR_874367.3 RNA Sequence