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THY1 Thy-1 cell surface antigen [ Homo sapiens (human) ]

Gene ID: 7070, updated on 11-Sep-2019

Summary

Official Symbol
THY1provided by HGNC
Official Full Name
Thy-1 cell surface antigenprovided by HGNC
Primary source
HGNC:HGNC:11801
See related
Ensembl:ENSG00000154096 MIM:188230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD90; CDw90
Summary
This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Broad expression in brain (RPKM 87.8), kidney (RPKM 58.0) and 16 other tissues See more
Orthologs

Genomic context

See THY1 in Genome Data Viewer
Location:
11q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119415476..119424985, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119288655..119294246, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 223 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene USP2 antisense RNA 1 (head to head) Neighboring gene major facilitator superfamily domain containing 14B pseudogene Neighboring gene double homeobox A pseudogene 5 Neighboring gene uncharacterized LOC107984398

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV Gag proteins adopt a ring-like supramolecular organization at sites of intercellular contacts and co-localize with CD63 tetraspanin and raft components GM1, Thy-1, and CD59 PubMed
gag The Matrix protein of HIV-1 Gag co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process PubMed
matrix gag HIV-1 Matrix co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GPI anchor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GPI anchor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron projection regeneration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular extravasation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of Rho-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal cone cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinal cone cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
anchored component of external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
axolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft NAS
Non-traceable Author Statement
more info
PubMed 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thy-1 membrane glycoprotein
Names
Thy-1 T-cell antigen
thy-1 antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311160.2NP_001298089.1  thy-1 membrane glycoprotein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001298089.1

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS8424.1
    UniProtKB/Swiss-Prot
    P04216
    UniProtKB/TrEMBL
    B0YJA4
    Related
    ENSP00000431301.1, ENST00000528522.5
    Conserved Domains (1) summary
    pfam00047
    Location:21117
    ig; Immunoglobulin domain
  2. NM_001311162.2NP_001298091.1  thy-1 membrane glycoprotein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001298091.1

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS8424.1
    UniProtKB/Swiss-Prot
    P04216
    UniProtKB/TrEMBL
    B0YJA4
    Related
    ENSP00000435753.1, ENST00000524659.1
    Conserved Domains (1) summary
    pfam00047
    Location:21117
    ig; Immunoglobulin domain
  3. NM_001372050.1NP_001358979.1  thy-1 membrane glycoprotein isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003396
  4. NM_006288.5NP_006279.2  thy-1 membrane glycoprotein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006279.2

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS8424.1
    UniProtKB/Swiss-Prot
    P04216
    UniProtKB/TrEMBL
    B0YJA4
    Related
    ENSP00000284240.5, ENST00000284240.9
    Conserved Domains (1) summary
    pfam00047
    Location:21117
    ig; Immunoglobulin domain

RNA

  1. NR_164077.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003396

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    119415476..119424985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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