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Zcchc8 zinc finger, CCHC domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 70650, updated on 8-May-2024

Summary

Official Symbol
Zcchc8provided by MGI
Official Full Name
zinc finger, CCHC domain containing 8provided by MGI
Primary source
MGI:MGI:1917900
See related
Ensembl:ENSMUSG00000029427 AllianceGenome:MGI:1917900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730565F05Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in ncRNA processing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear body. Predicted to be part of TRAMP complex and catalytic step 2 spliceosome. Is expressed in several structures, including blastocyst; early embryo; eye; secondary oocyte; and trunk somite. Orthologous to human ZCCHC8 (zinc finger CCHC-type containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.9), testis adult (RPKM 13.8) and 28 other tissues See more
Orthologs
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Genomic context

See Zcchc8 in Genome Data Viewer
Location:
5 F; 5 63.14 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123836365..123859107, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123698302..123721044, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:123993667-123993967 Neighboring gene VPS33A CORVET/HOPS core subunit Neighboring gene STARR-positive B cell enhancer ABC_E2176 Neighboring gene CAP-GLY domain containing linker protein 1 Neighboring gene STARR-seq mESC enhancer starr_14324 Neighboring gene predicted gene, 24840 Neighboring gene STARR-seq mESC enhancer starr_14325 Neighboring gene STARR-seq mESC enhancer starr_14326 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E104 Neighboring gene arginine/serine-rich coiled-coil 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of TRAMP complex ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCHC domain-containing protein 8
Names
TRAMP-like complex RNA-binding factor ZCCHC8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027494.3NP_081770.3  zinc finger CCHC domain-containing protein 8

    See identical proteins and their annotated locations for NP_081770.3

    Status: VALIDATED

    Source sequence(s)
    AK043312, AK167126, BY090296
    Consensus CDS
    CCDS80406.1
    UniProtKB/Swiss-Prot
    Q3TK71, Q8CCB7, Q91WQ1, Q9CYA6
    UniProtKB/TrEMBL
    Q3TKH5
    Related
    ENSMUSP00000142363.2, ENSMUST00000196282.5
    Conserved Domains (2) summary
    pfam00098
    Location:230247
    zf-CCHC; Zinc knuckle
    cl02643
    Location:286338
    PSP; PSP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123836365..123859107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530457.1XP_006530520.1  zinc finger CCHC domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    smart00343
    Location:4458
    ZnF_C2HC; zinc finger
    cl02643
    Location:98150
    PSP
  2. XM_011248240.4XP_011246542.1  zinc finger CCHC domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    smart00343
    Location:1226
    ZnF_C2HC; zinc finger
    cl02643
    Location:66118
    PSP