Oip5 Opa interacting protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oip5provided by MGI
Official Full Name: Opa interacting protein 5provided by MGI
Primary source: MGI:MGI:1917895
See related: Ensembl:ENSMUSG00000072980 AllianceGenome:MGI:1917895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ms18b; Lint-25; 5730547N13Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in CENP-A containing chromatin assembly and chromosome segregation. Predicted to act upstream of or within cell division. Located in chromocenter and nucleus. Orthologous to human OIP5 (Opa interacting protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 11.1), liver E14.5 (RPKM 10.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 E5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119440013..119448986, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119609532..119618505, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis.
Title: Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis.
Increase of Oip5 may associate with development of obesity.
Title: Possible involvement of Opa-interacting protein 5 in adipose proliferation and obesity.

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General gene information

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Homology

Homologs of the Oip5 gene: The Oip5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and chicken.
Orthologs from Annotation Pipeline: 326 organisms have orthologs with human gene Oip5
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in chromatin	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info	PubMed
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: protein Mis18-beta

Names: opa-interacting protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.