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Dcp2 decapping mRNA 2 [ Mus musculus (house mouse) ]

Gene ID: 70640, updated on 24-Jan-2023

Summary

Official Symbol
Dcp2provided by MGI
Official Full Name
decapping mRNA 2provided by MGI
Primary source
MGI:MGI:1917890
See related
Ensembl:ENSMUSG00000024472 AllianceGenome:MGI:1917890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410015D23Rik; 5730537H01Rik
Summary
Predicted to enable 5'-3' exoribonuclease activity and m7G(5')pppN diphosphatase activity. Involved in mRNA catabolic process. Predicted to be located in cell junction; cytoplasmic ribonucleoprotein granule; and nucleoplasm. Predicted to be part of RISC complex. Predicted to be active in P-body. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human DCP2 (decapping mRNA 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.4), cerebellum adult (RPKM 6.5) and 27 other tissues See more
Orthologs
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Genomic context

See Dcp2 in Genome Data Viewer
Location:
18; 18 B3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (44513567..44558036)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (44380500..44424969)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41717 Neighboring gene myotilin Neighboring gene mutated in colorectal cancers Neighboring gene predicted gene, 52347 Neighboring gene RIKEN cDNA A930012L18 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables 5'-3' RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables m7G(5')pppN diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
m7GpppN-mRNA hydrolase
Names
DCP2 decapping enzyme homolog
mRNA-decapping enzyme 2
NP_081766.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027490.1NP_081766.1  m7GpppN-mRNA hydrolase

    See identical proteins and their annotated locations for NP_081766.1

    Status: VALIDATED

    Source sequence(s)
    AC147551, AK153105, AK153310
    Consensus CDS
    CCDS50275.1
    UniProtKB/Swiss-Prot
    Q3TLD9, Q9CYC6
    UniProtKB/TrEMBL
    Q3U671
    Related
    ENSMUSP00000025350.9, ENSMUST00000025350.10
    Conserved Domains (2) summary
    cd03672
    Location:97246
    Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
    pfam05026
    Location:1294
    DCP2; Dcp2, box A domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    44513567..44558036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)