U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Med26 mediator complex subunit 26 [ Mus musculus (house mouse) ]

Gene ID: 70625, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Official Symbol
Med26provided by MGI
Official Full Name
mediator complex subunit 26provided by MGI
Primary source
MGI:MGI:1917875
See related
Ensembl:ENSMUSG00000045248 AllianceGenome:MGI:1917875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crsp7; 5730493L18Rik
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in several structures, including central nervous system; limb; retina; and tongue. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in testis adult (RPKM 35.9), ovary adult (RPKM 12.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Med26 in Genome Data Viewer
Location:
8 B3.3; 8 35.08 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73248402..73302154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72494555..72548310, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene STARR-positive B cell enhancer ABC_E6662 Neighboring gene microRNA 7068 Neighboring gene solute carrier family 35, member E1 Neighboring gene STARR-positive B cell enhancer ABC_E2267 Neighboring gene uncharacterized LOC102639683 Neighboring gene STARR-seq mESC enhancer starr_21873 Neighboring gene adaptor protein complex AP-2, mu1 pseudogene Neighboring gene predicted gene, 35857 Neighboring gene STARR-positive B cell enhancer ABC_E6663 Neighboring gene STARR-seq mESC enhancer starr_21875 Neighboring gene STARR-positive B cell enhancer ABC_E1760 Neighboring gene small integral membrane protein 7 Neighboring gene transmembrane protein 38A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. Takahashi H, et al. Nat Commun, 2015 Jan 9. PMID 25575120, Free PMC Article
  2. The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis. Gyuris A, et al. Biochim Biophys Acta, 2009 May. PMID 19362612, Free PMC Article
  3. Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Kolonay DW, et al. Front Cell Dev Biol, 2024. PMID 38690566, Free PMC Article
  4. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. Mittler G, et al. EMBO Rep, 2001 Sep. PMID 11559591, Free PMC Article
  5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mediator of RNA polymerase II transcription subunit 26
Names
CRSP complex subunit 7
cofactor required for Sp1 transcriptional activation subunit 7
cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027485.4 → NP_081761.2  mediator of RNA polymerase II transcription subunit 26

    See identical proteins and their annotated locations for NP_081761.2

    Status: VALIDATED

    Source sequence(s)
    BC054737, BY059601
    Consensus CDS
    CCDS22416.1
    UniProtKB/Swiss-Prot
    Q7TN02, Q8BUP9, Q8R1G7, Q9CS67
    Related
    ENSMUSP00000058697.6, ENSMUST00000058534.7
    Conserved Domains (3) summary
    smart00509
    Location:12 → 86
    TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
    pfam15693
    Location:407 → 586
    Med26_C; Mediator complex subunit 26 C-terminal
    pfam15694
    Location:178 → 405
    Med26_M; Mediator complex subunit 26 middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73248402..73302154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN02.1 GenPept UniProtKB/Swiss-Prot:Q7TN02

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools