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Med26 mediator complex subunit 26 [ Mus musculus (house mouse) ]

Gene ID: 70625, updated on 5-Mar-2024

Summary

Official Symbol
Med26provided by MGI
Official Full Name
mediator complex subunit 26provided by MGI
Primary source
MGI:MGI:1917875
See related
Ensembl:ENSMUSG00000045248 AllianceGenome:MGI:1917875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crsp7; 5730493L18Rik
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in central nervous system; limb; and retina. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 35.9), ovary adult (RPKM 12.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 B3.3; 8 35.08 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73248402..73302154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72494555..72548310, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene STARR-positive B cell enhancer ABC_E6662 Neighboring gene microRNA 7068 Neighboring gene solute carrier family 35, member E1 Neighboring gene STARR-positive B cell enhancer ABC_E2267 Neighboring gene uncharacterized LOC102639683 Neighboring gene STARR-seq mESC enhancer starr_21873 Neighboring gene adaptor protein complex AP-2, mu1 pseudogene Neighboring gene predicted gene, 35857 Neighboring gene STARR-positive B cell enhancer ABC_E6663 Neighboring gene STARR-seq mESC enhancer starr_21875 Neighboring gene STARR-positive B cell enhancer ABC_E1760 Neighboring gene small integral membrane protein 7 Neighboring gene transmembrane protein 38A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 26
Names
CRSP complex subunit 7
cofactor required for Sp1 transcriptional activation subunit 7
cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027485.4NP_081761.2  mediator of RNA polymerase II transcription subunit 26

    See identical proteins and their annotated locations for NP_081761.2

    Status: VALIDATED

    Source sequence(s)
    BC054737, BY059601
    Consensus CDS
    CCDS22416.1
    UniProtKB/Swiss-Prot
    Q7TN02, Q8BUP9, Q8R1G7, Q9CS67
    Related
    ENSMUSP00000058697.6, ENSMUST00000058534.7
    Conserved Domains (3) summary
    smart00509
    Location:1286
    TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
    pfam15693
    Location:407586
    Med26_C; Mediator complex subunit 26 C-terminal
    pfam15694
    Location:178405
    Med26_M; Mediator complex subunit 26 middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73248402..73302154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)