Med26 mediator complex subunit 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Med26provided by MGI
Official Full Name: mediator complex subunit 26provided by MGI
Primary source: MGI:MGI:1917875
See related: Ensembl:ENSMUSG00000045248 AllianceGenome:MGI:1917875
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crsp7; 5730493L18Rik
Summary: Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in central nervous system; limb; and retina. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 35.9), ovary adult (RPKM 12.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 B3.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (73248402..73302154, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (72494555..72548310, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI414941 (e-PCR)
- UniSTS:164380

AW495270 (e-PCR)
- UniSTS:179764

Homology

Homologs of the Med26 gene: The Med26 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 495 organisms have orthologs with human gene Med26
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of core mediator complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of core mediator complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of mediator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 26

Names: CRSP complex subunit 7; cofactor required for Sp1 transcriptional activation subunit 7; cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027485.4 → NP_081761.2 mediator of RNA polymerase II transcription subunit 26

See identical proteins and their annotated locations for NP_081761.2

Status: VALIDATED

Source sequence(s)

BC054737, BY059601

Consensus CDS

CCDS22416.1

UniProtKB/Swiss-Prot

Q7TN02, Q9CS67

Related

ENSMUSP00000058697.6, ENSMUST00000058534.7

Conserved Domains (3) summary

smart00509
Location:12 → 86

TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)

pfam15693
Location:407 → 586

Med26_C; Mediator complex subunit 26 C-terminal

pfam15694
Location:178 → 405

Med26_M; Mediator complex subunit 26 middle domain