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THBS3 thrombospondin 3 [ Homo sapiens (human) ]

Gene ID: 7059, updated on 13-Mar-2020

Summary

Official Symbol
THBS3provided by HGNC
Official Full Name
thrombospondin 3provided by HGNC
Primary source
HGNC:HGNC:11787
See related
Ensembl:ENSG00000169231 MIM:188062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSP3
Summary
The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in endometrium (RPKM 9.2), gall bladder (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See THBS3 in Genome Data Viewer
Location:
1q22
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155195588..155209180, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155165379..155177772, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mucin 1, cell surface associated Neighboring gene THBS3 antisense RNA 1 Neighboring gene microRNA 92b Neighboring gene GBAP1 recombination region Neighboring gene metaxin 1 Neighboring gene glucosylceramidase beta pseudogene 1 Neighboring gene GBA recombination region Neighboring gene metaxin 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with THBS3; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119564, MGC119565

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
growth plate cartilage development IEA
Inferred from Electronic Annotation
more info
 
ossification involved in bone maturation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047083.1 RefSeqGene

    Range
    6284..18593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252607.1NP_001239536.1  thrombospondin-3 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC234582, AK314337, BC018786, DA755868
    Consensus CDS
    CCDS72937.1
    UniProtKB/Swiss-Prot
    P49746
    UniProtKB/TrEMBL
    F5H4Z8
    Related
    ENSP00000444792.2, ENST00000541576.5
    Conserved Domains (9) summary
    smart00210
    Location:23193
    TSPN; Thrombospondin N-terminal -like domains
    cd00054
    Location:307342
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:519541
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:542577
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:449482
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:543577
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:732929
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:369398
    EGF_3; EGF domain
    cd16079
    Location:218260
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
  2. NM_001252608.2NP_001239537.1  thrombospondin-3 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001239537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK298592, BC018786
    Consensus CDS
    CCDS58034.1
    UniProtKB/Swiss-Prot
    P49746
    Related
    ENSP00000392207.2, ENST00000457183.6
    Conserved Domains (9) summary
    cd00054
    Location:196231
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:408430
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:431466
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:338371
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:432466
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:621818
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:258287
    EGF_3; EGF domain
    cd16079
    Location:107149
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    cl22861
    Location:23118
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. NM_007112.5NP_009043.1  thrombospondin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_009043.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC234582, BC018786, L38969
    Consensus CDS
    CCDS1099.1
    UniProtKB/Swiss-Prot
    P49746
    Related
    ENSP00000357362.3, ENST00000368378.7
    Conserved Domains (9) summary
    smart00210
    Location:23193
    TSPN; Thrombospondin N-terminal -like domains
    cd00054
    Location:316351
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:528550
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:551586
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:458491
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:552586
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:741938
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:378407
    EGF_3; EGF domain
    cd16079
    Location:227269
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)

RNA

  1. NR_045553.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC018786, BC113846
    Related
    ENST00000541990.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155195588..155209180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509935.1XP_011508237.1  thrombospondin-3 isoform X8

    See identical proteins and their annotated locations for XP_011508237.1

    Conserved Domains (8) summary
    cd00054
    Location:137172
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:349371
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:372407
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:279312
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:373407
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:565762
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:199228
    EGF_3; EGF domain
    cd16079
    Location:4890
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
  2. XM_011509933.1XP_011508235.1  thrombospondin-3 isoform X7

    See identical proteins and their annotated locations for XP_011508235.1

    Conserved Domains (9) summary
    cd00054
    Location:278313
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:490512
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:513548
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:420453
    TSP3_1C; TSP3 repeat_1C [structural motif]
    cd16079
    Location:189231
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    pfam02412
    Location:513548
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:706903
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:340369
    EGF_3; EGF domain
    cl22861
    Location:2155
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. XM_011509931.1XP_011508233.1  thrombospondin-3 isoform X7

    See identical proteins and their annotated locations for XP_011508233.1

    Conserved Domains (9) summary
    cd00054
    Location:278313
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:490512
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:513548
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:420453
    TSP3_1C; TSP3 repeat_1C [structural motif]
    cd16079
    Location:189231
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    pfam02412
    Location:513548
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:706903
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:340369
    EGF_3; EGF domain
    cl22861
    Location:2155
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  4. XM_011509928.2XP_011508230.1  thrombospondin-3 isoform X4

    Conserved Domains (9) summary
    cd00054
    Location:342377
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:554576
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:577612
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:484517
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:578612
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:770967
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:404433
    EGF_3; EGF domain
    cd16079
    Location:253295
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    cl22861
    Location:51219
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  5. XM_011509927.2XP_011508229.1  thrombospondin-3 isoform X3

    Conserved Domains (9) summary
    cd00054
    Location:364399
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:576598
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:599634
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:506539
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:600634
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:792989
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:426455
    EGF_3; EGF domain
    cd16079
    Location:275317
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    cl22861
    Location:85250
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  6. XM_006711498.3XP_006711561.1  thrombospondin-3 isoform X2

    Conserved Domains (9) summary
    cd00054
    Location:373408
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:585607
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:608643
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:515548
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:609643
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:798995
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:435464
    EGF_3; EGF domain
    cd16079
    Location:284326
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    cl22861
    Location:85250
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  7. XM_011509930.2XP_011508232.1  thrombospondin-3 isoform X6

    Conserved Domains (9) summary
    cd00054
    Location:373408
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:585607
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:608643
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:515548
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:609643
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:801951
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:435464
    EGF_3; EGF domain
    cd16079
    Location:284326
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    cl22861
    Location:85250
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  8. XM_011509926.2XP_011508228.1  thrombospondin-3 isoform X1

    Conserved Domains (9) summary
    cd00054
    Location:373408
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:585607
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:608643
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:515548
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:609643
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:801998
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:435464
    EGF_3; EGF domain
    cd16079
    Location:284326
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    cl22861
    Location:85250
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  9. XM_011509929.2XP_011508231.1  thrombospondin-3 isoform X5

    Conserved Domains (9) summary
    smart00210
    Location:23193
    TSPN; Thrombospondin N-terminal -like domains
    cd00054
    Location:316351
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:528550
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:551586
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:458491
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:552586
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:744941
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:378407
    EGF_3; EGF domain
    cd16079
    Location:227269
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
  10. XM_017002206.1XP_016857695.1  thrombospondin-3 isoform X10

  11. XM_011509936.1XP_011508238.1  thrombospondin-3 isoform X9

    Conserved Domains (8) summary
    cd00054
    Location:6196
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:273295
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:296331
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:203236
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:297331
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:489686
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:123152
    EGF_3; EGF domain
    cl13107
    Location:114
    TSPcc; Coiled coil region of thrombospondin
  12. XM_011509934.1XP_011508236.1  thrombospondin-3 isoform X8

    See identical proteins and their annotated locations for XP_011508236.1

    Conserved Domains (8) summary
    cd00054
    Location:137172
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:349371
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:372407
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:279312
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:373407
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:565762
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:199228
    EGF_3; EGF domain
    cd16079
    Location:4890
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
  13. XM_024449430.1XP_024305198.1  thrombospondin-3 isoform X7

    Conserved Domains (9) summary
    cd00054
    Location:278313
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:490512
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:513548
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:420453
    TSP3_1C; TSP3 repeat_1C [structural motif]
    cd16079
    Location:189231
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    pfam02412
    Location:513548
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:706903
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:340369
    EGF_3; EGF domain
    cl22861
    Location:2155
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  14. XM_011509932.2XP_011508234.1  thrombospondin-3 isoform X7

    See identical proteins and their annotated locations for XP_011508234.1

    Conserved Domains (9) summary
    cd00054
    Location:278313
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:490512
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:513548
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:420453
    TSP3_1C; TSP3 repeat_1C [structural motif]
    cd16079
    Location:189231
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    pfam02412
    Location:513548
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:706903
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:340369
    EGF_3; EGF domain
    cl22861
    Location:2155
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RNA

  1. XR_002957482.1 RNA Sequence

  2. XR_426793.3 RNA Sequence

  3. XR_002957483.1 RNA Sequence

  4. XR_001737388.2 RNA Sequence

  5. XR_001737389.1 RNA Sequence

  6. XR_001737384.1 RNA Sequence

  7. XR_001737385.1 RNA Sequence

  8. XR_921913.2 RNA Sequence

  9. XR_001737387.1 RNA Sequence

  10. XR_921914.3 RNA Sequence

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