Format

Send to:

Choose Destination

THBS1 thrombospondin 1 [ Homo sapiens (human) ]

Gene ID: 7057, updated on 17-Apr-2020

Summary

Official Symbol
THBS1provided by HGNC
Official Full Name
thrombospondin 1provided by HGNC
Primary source
HGNC:HGNC:11785
See related
Ensembl:ENSG00000137801 MIM:188060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSP; THBS; TSP1; TSP-1; THBS-1
Summary
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 304.9), gall bladder (RPKM 219.5) and 16 other tissues See more
Orthologs

Genomic context

See THBS1 in Genome Data Viewer
Location:
15q14
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (39581079..39599466)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (39873280..39889668)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370783 Neighboring gene uncharacterized LOC105370784 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene uncharacterized LOC105370785 Neighboring gene uncharacterized LOC105370941

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env TSP1 inhibits HIV-1 infection of peripheral blood mononuclear cells and transformed T and promonocytic cell lines by its binding to HIV-1 gp120 PubMed
env Interaction of TSP1 with HIV-1 gp120 involves CSVTCG sequences in the type 1 properdin-like repeats of TSP1 and amino acids 281-300, 311-330, and 361-380 in the C2-V3-C3 domains of gp120 PubMed
Tat tat Thrombospondin-1 (TSP) prevents endothelial cell motility induced by HIV-1 Tat and inhibits angiogenic activity exerted by Tat in the Matrigel sponge model, suggesting downregulation of TSP may be permissive for development of KS-associated angiogenesis PubMed
tat Thrombospondin-1 inhibits cell internalization and HIV-1 LTR transactivating activity of extracellular HIV-1 Tat, cell interaction and mitogenic activity of extracellular Tat, as well as the autocrine loop of stimulation exerted by endogenous Tat PubMed
tat Thrombospondin-1 (TSP) binds to HIV-1 Tat, an interaction that can be inhibited by heparin which can bind to both TSP and Tat PubMed
Vpr vpr HIV-1 Vpr potentiates the stimulation of thrombospondin 1 by glucocorticoids via the glucocorticoid receptor pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
collagen V binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix structural constituent HDA PubMed 
extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
fibrinogen binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding NAS
Non-traceable Author Statement
more info
PubMed 
integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proteoglycan binding TAS
Traceable Author Statement
more info
PubMed 
transforming growth factor beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to pain ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
chronic inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
engulfment of apoptotic cell IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
immune response IEP
Inferred from Expression Pattern
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of dendritic cell antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of fibrinolysis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of focal adhesion assembly TAS
Traceable Author Statement
more info
PubMed 
negative regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of plasma membrane long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transforming growth factor beta1 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia NAS
Non-traceable Author Statement
more info
PubMed 
response to magnesium ion IDA
Inferred from Direct Assay
more info
PubMed 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to progesterone TAS
Traceable Author Statement
more info
PubMed 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
collagen-containing extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
fibrinogen complex IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thrombospondin-1
Names
glycoprotein G
thrombospondin-1p180
thrombospondin-p50

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003246.4NP_003237.2  thrombospondin-1 precursor

    See identical proteins and their annotated locations for NP_003237.2

    Status: REVIEWED

    Source sequence(s)
    AC037198, AI147670, AI168683, AK304754, BC015134, BC136470, BG115371, BM512145, BM784452, BU676185, X14787
    Consensus CDS
    CCDS32194.1
    UniProtKB/Swiss-Prot
    P07996
    Related
    ENSP00000260356.5, ENST00000260356.6
    Conserved Domains (10) summary
    smart00209
    Location:438490
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:26221
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:845882
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:787821
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:691726
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00090
    Location:383428
    TSP_1; Thrombospondin type 1 domain
    pfam00093
    Location:318372
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:846882
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:9721169
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:650689
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    39581079..39599466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521971.2XP_011520273.1  thrombospondin-1 isoform X1

    Conserved Domains (10) summary
    smart00209
    Location:438490
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:26221
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:787824
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:729763
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:633668
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00090
    Location:383428
    TSP_1; Thrombospondin type 1 domain
    pfam00093
    Location:318372
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:788824
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:9141111
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:592631
    EGF_3; EGF domain
Support Center